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ns to differentiate between MCI patients who are likely to develop AD, versus those who might progress to DLB or remain stable.Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for the development of cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in cervical disease onset and progression either by favoring or by preventing HPV infection and persistence. The microbiome of a healthy female genital tract is characterized by the presence of 1 or few varieties of lactobacilli. However, high-throughput studies addressing the bacterial diversity and abundance in the female genital tract have shown that several factors, including hormonal levels, hygiene habits, and sexually transmitted diseases may disrupt the natural balance, favoring the outgrowth of some groups of bacteria, which in turn may favor some pathological states. Recently, the vaginal microbiome has emerged as a new variable that could greatly influence the natural history of HPV infections and their clinical impact. In this context, changes in the vaginal microbiome have been detected in women infected with HPV and women with HPV-associated lesions and cancer. However, the role of specific bacteria groups in the development/progression or prevention/regression of HPV-associated pathologies is not well understood. In this review we summarize the current knowledge concerning changes in vaginal microbiome and cervical disease. We discuss the potential functional interplay between specific bacterial groups and HPV infection outcomes.

Deep brain stimulation (DBS) is an effective surgical treatment for movement disorders. Early versions of implantable systems delivered stimulation with constant voltage (CV); however, advances in available and newer platforms have permitted programming in constant current (CC). From a treatment management perspective, there are theoretical advantages of CC stimulation. In this case series, we present clinical evidence supporting the maintenance of current regardless of changes to impedance.

This case series included 3 patients with Parkinson's disease status post-bilateral subthalamic nucleus DBS. Patients in this series self-reported intermittent diplopia with pressure applied to the scalp. Patients were subsequently examined and converted from CV to CC and re-examined. Impedances were checked prior to and after conversion from CV to CC as well as while applying pressure to the scalp that induced the adverse effects.

Across patients, we observed that compression of the scalp overlying the connector, while patients were maintained in CV, consistently and objectively induced unilateral adduction of an eye. In addition, during scalp compression, while in CV, impedance was reduced, which would increase current delivery. Converting the patients to CC stimulation without changing other stimulation parameters eliminated diplopia and objective findings of eye deviation with compression of the scalp overlying the hardware despite changes in impedance.

In this case series, we provide clinical support for the principal differences between CV and CC stimulation.

In this case series, we provide clinical support for the principal differences between CV and CC stimulation.Information and Communication Technologies (ICT) are broadly used to support people's daily needs. Individuals addicted to psychoactive drugs sometimes present social exclusion as well as, limitations to the usage of ICT such as Internet, devices and applications. The aim of this paper is to present the findings of a pilot study related to the use of Information and Communication Technologies by Drug Addicts. A survey was conducted on 204 users of psychoactive substances. According to the results, the majority of the drug addicts seem to use ICT on a daily basis, showing their preference on Smartphones compared to other devices. The Internet access and the usage of Social Media and Communication Networks by addicted individuals is quite high, probably because they are willing to reintegrate into the society through Social Networks. Age is often related to the usage of ICT on Drug Addicts.An Electronic Health Insurance Record (EHIR) could give all the information needed to the insured citizens, informing them about the history of benefits and the health expenses. The aim of this work is to evaluate a Digital Health Insurance Record system as well as to explore the benefits of using this system, both for society and for each citizen individually. A quantitative survey was carried out using a questionnaire shared among 180 people in Greece in 2019. The questionnaire consisted of 25 closed-ended questions, 3 of which related to demographics and the remaining 22 related to the use and benefits of use of the EHIR system. Most of all people who took part in this study believe that EHIR can contribute positively giving both social benefits and benefits for the patients. An important finding of the study is the concern expressed by respondents about the security of the system in the management of sensitive personal data. Based on citizens' opinions a Digital Health Insurance Record can provide a lot of benefits to citizens and to the society as well as to the national health insurance system.Physical activity is a vital part of cardiac rehabilitation (CR). selleck inhibitor However, heart-healthy physical activity levels in people with cardiovascular disease drop significantly after CR. This exploratory study employs qualitative and survey methods within a co-creation approach. The aim is to understand the mechanisms of healthy behavior and habit formation in order to create a novel evidence-based (post-)rehabilitation approach that employs digital means to sustain long-term physical activity levels in people with cardiovascular disease.This paper presents the design and the users' perceptions of a Digital Allergy Card for recording, sharing and tracing information on drug allergies.Self-management for prevention and care will play a significant role in the transition to apply person-centered care. Interoperability requirements, an overarching care plan, integration of social determinants, and the focus on prevention are important ingredients in the vision on its implementation.