Smithbehrens4968

In this work we propose a model for open Markov chains that can be interpreted as a system of non-interacting particles evolving according to the rules of a Markov chain. The number of particles in the system is not constant, because we allow the particles to arrive or leave the state space according to prescribed protocols. We describe this system by looking at the population of particles on every state by establishing the rules of time-evolution of the distribution of particles. We show that it is possible to describe the distribution of particles over the state space through the corresponding moment generating function. This description is given through the dynamics ruling the behavior of such a moment generating function and we prove that the system is able to attain the stationarity under some conditions. We also show that it is possible to describe the dynamics of the two first cumulants of the distribution of particles, which in some way is a simpler technique to obtain useful information of the open Markov chain for practical purposes. Finally we also study the behavior of the time-dependent correlation functions of the number of particles present in the system. We give some simple examples of open chains that either, can be fully described through the moment generating function or partially described through the exact solution of the cumulant dynamics.We present here a somewhat personalized account of the emergence of econophysics as an attractive research topic in physical, as well as social, sciences. After a rather detailed storytelling about our endeavors from Kolkata, we give a brief description of the main research achievements in a simple and non-technical language. We also briefly present, in technical language, a piece of our recent research result. We conclude our paper with a brief perspective.The modulation of protein-protein interactions (PPIs) by small molecules represents a valuable strategy for pharmacological intervention in several human diseases. In this context, computer-aided drug discovery techniques offer useful resources to predict the network of interactions governing the recognition process between protein partners, thus furnishing relevant information for the design of novel PPI modulators. In this work, we focused our attention on the MUC1-CIN85 complex as a crucial PPI controlling cancer progression and metastasis. MUC1 is a transmembrane glycoprotein whose extracellular domain contains a variable number of tandem repeats (VNTRs) regions that are highly glycosylated in normal cells and under-glycosylated in cancer. The hypo-glycosylation fosters the exposure of the backbone to new interactions with other proteins, such as CIN85, that alter the intracellular signalling in tumour cells. Herein, different computational approaches were combined to investigate the molecular recognition pattern of MUC1-CIN85 PPI thus unveiling new structural information useful for the design of MUC1-CIN85 PPI inhibitors as potential anti-metastatic agents.At present, high-speed underwater acoustic communication requires underwater transducers with the characteristics of low frequency and broadband. The low-frequency transducers also are expected to be low-frequency directional for realization of point-to-point communication. In order to achieve the above targets, this paper proposes a new type of flextensional transducer which is constructed of double mosaic piezoelectric ceramic rings and spherical cap metal shells. The transducer realizes broadband transmission by means of the coupling between radial vibration of the piezoelectric rings and high-order flexural vibration of the spherical cap metal shells. The low-frequency directional transmission of the transducer is realized by using excitation signals with different amplitude and phase on two mosaic piezoelectric rings. The relationship between transmitting voltage response (TVR), resonance frequency and structural parameters of the transducer is analyzed by finite element software COMSOL. The broadband performance of the transducer is also optimized. On this basis, the low-frequency directivity of the transducer is further analyzed and the ratio of the excitation signals of the two piezoelectric rings is obtained. Finally, a prototype of the broadband ring flextensional underwater transducer is fabricated according to the results of simulation. The electroacoustic performance of the transducer is tested in an anechoic water tank. Experimental results show that the maximum TVR of the transducer is 147.2 dB and the operation bandwidth is 1.5-4 kHz, which means that the transducer has good low-frequency, broadband transmission capability. Meanwhile, cardioid directivity is obtained at 1.4 kHz and low-frequency directivity is realized.Tertiary care centres continue to experience over-utilisation of diagnostic imaging services for lower back pain cases that may not be required. Moreover, these services may require additional time and consequently delay access to services that offer conservative management, i.e., physiotherapy, and hence, increase the direct and indirect costs with no added quality of care. A logic model was developed based on qualitative and quantitative studies that explains the plan and process evaluation strategies to reduce imaging for lower back pain in tertiary hospitals. Logic models are useful tools for defining programme components. The delivery of the components is ensured by well-defined process evaluations that identify any needed modifications. The proposed logic model provides a road map for spine clinics in tertiary care hospitals to decrease the number of patient referrals for magnetic resonance imaging and waiting times for consultations and services and promote early access to physiotherapy services.HIV self-testing has emerged as a safe and effective approach to increase the access to and uptake of HIV testing and treatment, especially for key populations. Applying self-testing to hepatitis C virus (HCV) may also offer an additional way to address low coverage of HCV testing and to accelerate elimination efforts. To understand the potential for HCV self-testing (HCVST), an observational study was conducted to assess the acceptability and usability of the OraQuick® HCV Self-Test (prototype) among people who inject drugs (PWID) and men who have sex with men (MSM) in Thai Nguyen, a province in northern Vietnam. A total of 105 PWID and 104 MSM were eligible and agreed to participate in the study. Everolimus Acceptability, defined as the proportion of participants among eligible subjects who agreed to participate in the study, was 92.9% in PWID and 98.6% in MSM. Compared to MSM, PWID were older (median age 45 vs. 22 years; p less then 0.0001) and had a lower education level (high school and college 38.1% vs. 100%; p less then 0.