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Rates of suicide attempts are highest among younger ages and women, and especially elevated among sexual minorities (lesbian, gay, and bisexual [LGB] people). We examined the prevalence of lifetime suicide ideation among sexual minorities and sought to determine whether this relationship depended on age and gender.

Using data from the Annual Component of the 2015-2016 Canadian Community Health Survey (CCHS), participants were asked whether they had seriously contemplated suicide (lifetime suicidal ideation yes/no). In adjusted multiple logistic regression analyses, we entered a sexual orientation by gender and age (three-way) interaction.

There was evidence of an interaction between sexual orientation, gender, and age on lifetime suicidal ideation (Wald χ

p=0.009); the strength of the relationship between sexual orientation and suicidal ideation varied by gender and age. α-cyano-4-hydroxycinnamic molecular weight Lesbian/gay and bisexual respondents of both genders were more likely to report suicidal ideation across the life span, when compared to heterosexuals. This finding was strongest for bisexual respondents.

The results highlight the relevance of sexual orientation as a social determinant of lifetime suicidal ideation. Suicide prevention and surveillance efforts should take into consideration that sexual minorities, especially bisexual persons, disproportionately consider harming themselves when compared to the heterosexual population.

The results highlight the relevance of sexual orientation as a social determinant of lifetime suicidal ideation. Suicide prevention and surveillance efforts should take into consideration that sexual minorities, especially bisexual persons, disproportionately consider harming themselves when compared to the heterosexual population.

Although both PSA nadir (PSAn) and testosterone levels at PSA failure are known prognostic factors in men undergoing radiation therapy (RT) and androgen deprivation therapy (ADT) for unfavorable-risk prostate cancer (PC), it is unclear whether their prognostic significance is independent or overlapping.

Seventy-five men treated with RT with or without 6months of ADT for unfavorable-risk nonmetastatic PC enrolled in 2 prospective clinical trials between 1986 and 2001 formed the study cohort. Competing risks and Cox multivariable regression were used to assess whether low versus normal serum testosterone at the time of PSA failure and higher PSAn after initial therapy were independently associated with the risk of PC-specific (PCSM) and all-cause mortality (ACM) adjusting for PC prognostic factors.

After a median follow-up of 15.34years (interquartile range, 6.66-16.88years), there were 53 deaths (73.3%) 30 (56.6%) were from PC. Low testosterone at PSA failure was significantly associated with an increaseowever, higher PSA nadir was only found to be of prognostic significance in men with normal testosterone levels at PSA failure.

This study investigates whether the prostate-specific antigen (PSA) nadir and normal versus low testosterone at the time of PSA failure provide mutually exclusive or overlapping prognostic information following treatment with radiation and androgen deprivation therapy for unfavorable-risk patients with prostate cancer using data from 2 prospective clinical trials. It was found that both provided prognostic information; however, higher PSA nadir was only found to be of prognostic significance in men with normal testosterone levels at PSA failure.

The costs associated with immune and thermal responses may exceed the benefits to the host during severe inflammation. In this case, regulated hypothermia instead of fever can occur in rodents as a beneficial strategy to conserve energy for vital functions with consequent tissue protection and hypoxia prevention. We tested the hypothesis that this phenomenon is not exclusive to mammals, but extends to the other endothermic group, birds. A decrease in metabolic rate without any failure in mitochondrial respiration, nor oxygen delivery, is the main evidence supporting the regulated nature of endotoxin-induced hypothermia in chicks. Thermolytic mechanisms such as tachypnea and cutaneous vasodilatation can also be recruited to facilitate body temperature decrease under lipopolysaccharide treatment, especially in the cold. Our findings bring a new perspective for evolutionary medicine studies on energy trade-off in host defence because regulated hypothermia may be a phenomenon spread among vertebrates facing a so O2 delivery limitation. Additionally, chicks did not attempt to prevent Tb from falling during hypothermia but, instead, activated cutaneous and respiratory thermolytic mechanisms, providing an additional cooling force. These data provide the first evidence of the regulated nature of the hypothermic response to endotoxin in birds. Therefore, it changes the current understanding of bird's thermoregulation during severe inflammation, indicating that regulated hypothermia is either a convergent trait for endotherms or a conserved response among vertebrates, which adds a new perspective for evolutionary medicine research.

The developmental changes of the caval (SVC) and pulmonary vein (PV) myocardium electrophysiology are traced throughout postnatal ontogenesis. The myocardium in SVC as well as in PV demonstrate age-dependent differences in the ability to maintain resting membrane potential, to manifest automaticity in a form of ectopic action potentials in basal condition and in responses to the adrenergic stimulation. Electrophysiological characteristics of two distinct types of thoracic vein myocardium change in an opposite manner during early postnatal ontogenesis with increased proarrhythmicity of pulmonary and decreased automaticity in caval veins. Predisposition of PV cardiac tissue to proarrhythmycity develops during ontogenesis in time correlation with the establishment of sympathetic innervation of the tissue. The electrophysiological properties of caval vein cardiac tissue shift from a pacemaker-like phenotype to atrial phenotype in accompaniment with sympathetic nerve growth and adrenergic receptor expression charate RMP instability and proarrhythmic activity from the 14th day of postnatal life which correlates with the appearance of the sympathetic innervation of the thoracic veins. In addition, postnatal attenuation of SVC myocardium automaticity occurs concomitantly with sympathetic innervation establishment and increase in β1-ARs, but not α1A-AR levels. Our results support the contention that SVC and PV myocardium electrophysiology change during postnatal development, resulting in higher PV proarrhythmicity in adults.

The potential role of occupational exposures in the development of nasopharyngeal carcinoma (NPC) remains unclear, particularly in high-incidence areas.

The authors conducted a population-based case-control study, consisting of 2514 incident NPC cases and 2586 randomly selected population controls, in southern China from 2010 to 2014. Occupational history and other covariates were self-reported using a questionnaire. Multivariate logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the risk of NPC associated with occupational exposures. Restricted cubic splines were used to evaluate potentially nonlinear duration-response relations.

Individuals who had exposure to occupational dusts (OR, 1.45; 95% CI, 1.26-1.68), chemical vapors (OR, 1.37; 95% CI, 1.17-1.61), exhausts/smokes (OR, 1.42; 95% CI, 1.25-1.60), or acids/alkalis (OR, 1.56; 95% CI, 1.30-1.89) in the workplace had an increased NPC risk compared with those who were unexposed. Risk estimates for all 4 in southern China and observed that occupational exposures were associated with an increased risk of NPC. Duration-response trends were observed with increasing duration of exposure. These findings provide new evidence supporting an etiologic role of occupational exposures for NPC in a high-incidence region.

The role of occupational exposures in the development of nasopharyngeal carcinoma (NPC) remains unclear, particularly in high-incidence areas. The authors conducted a population-based study with 2514 incident NPC cases and 2586 population controls in southern China and observed that occupational exposures were associated with an increased risk of NPC. Duration-response trends were observed with increasing duration of exposure. These findings provide new evidence supporting an etiologic role of occupational exposures for NPC in a high-incidence region.The transition to college involves a number of novel stressors for young adults and represents a period of heightened risk for the onset or worsening of diverse mental health problems. The presence of natural mentors may be one factor which alleviates risk for mental health problems in college first-year students. Using a diverse sample of 275 first-year college students, the present study examined the effects of different types of natural mentors within students' support networks on internalizing symptoms during the first semester of college. In addition, analyses explored whether different student approaches to emotion regulation were one mechanism by which natural mentors influence internalizing symptoms. Path analyses indicated that students with a greater number of close family member/family friend mentors reported less emotion suppression, which in turn accounted for the associations between these mentoring relationships and reduced depressive symptoms and worry at follow-up. In contrast, less emotionally close mentors, such as teachers or coworkers, did not significantly shape emotion regulation strategies or internalizing symptom outcomes. Results have implications for the design of more targeted interventions that promote emotional well-being in college first-year students.

We investigated whether male high school students displaying high traditional masculinity (HTM), defined briefly as overacting male roles, possessed distinctive social origins and adult lifestyle trajectories differentiating them from others.

Based upon four survey waves of the National Longitudinal Study of Adolescent to Adult Health cross-linked to the National Death Index, we contrasted surveys 1 and 2 respondents reporting HTM, n=3138, 31%, with the remaining 69% (n=6849) on various sociodemographic characteristics, problem behaviors, suicides, and other premature mortalities.

High traditional masculinity males showed higher suicide rates, but no other differences in premature mortalities, compared with non-HTM peers. More likely to be White, younger, less close to their fathers, they were more likely to run away from home, get into fights, act delinquently, and engage in problem drinking and drug use. At survey wave 3, more had been arrested. By wave 4, when approaching their early thirties, HTM males showed higher drug uses, more delinquency, completed less schooling, and were less likely to marry.

These data not only suggest higher suicide risks among this population after high school, but judging from the durability of HTM characteristics, but also they appear at risk of "deaths of despair" during later life.

These data not only suggest higher suicide risks among this population after high school, but judging from the durability of HTM characteristics, but also they appear at risk of "deaths of despair" during later life.