Skytteasmussen7048

Treatment with MESBAD significantly (p less then 0.05) reduced the activities of AST and nMPCEs induced, histopatological examination of the liver showed that MESBAD reduced the severe portal and central venous congestion induced by SA, phytochemical analysis showed that MESBAD possess high concentration of alkaloids, saponins, flavonoids and total polyphenols. Methanol extract of the stem bark of Adansonia digitata mitigates SA-induced toxicities probably through radical scavenging activities.The challenges associated with adequate deployment of nucleic acid amplification tests (NAATs) in developing countries underscores the important role of simple but sensitive and specific serological testing kits in COVID-19 diagnosis. Presently, there are a number of point-of-care tests for Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) screening. However, the reliability of these test kits is poorly documented and hence, needs to be ascertained. This study was therefore designed to determine the sensitivity and specificity of two serological test kits for COVID-19 screening with the view to providing necessary information on the suitability of their deployment as routine test kits for SARS-CoV-2 in Nigeria. Forty-seven (47) asymptomatic adults who had been tested for SARS-CoV-2 with the real-time reverse-transcriptase polymerase-chain reaction (RT-PCR) were enrolled into this study. Blood samples were obtained for qualitative determination of serum IgM and IgG antibodies to the S-antigen of SA compared with RDT. In contrast, the proportion of participants with positive anti- SARS COV-2 IgG antibody identified using RDT was significantly higher compared with ELISA. ELISA has a better sensitivity for detecting anti-SARS-CoV-2 Spike-protein specific antibodies than the RDT. However, combination of RDT and ELISA for the detection of anti-SARS-COV-2 antibodies might be useful for population COVID-19 screening.Prof Eme E. Osim served Editor-in-Chief of Nigerian Journal of Physiological Sciences between 1999 and 2009. This tribute highlights his immense contributions to the development of the journal and academia.Intestinal Ischaemia-Reperfusion Injury as distinct from Ischaemia-Reperfusion Injury is what occurs when blood supply to the intestines is cut off either inadvertently in some gastrointestinal emergencies or during abdominal surgical interventions. R406 Syk inhibitor The phenomenon leads to formation of reactive oxygen species and subsequent up-regulation upon reaching the spleen and consequent effects in organs of the body such as increased sperm cell abnormalities. The changes which occur in the intestine and some distant organs due to remote effects of intestinal ischaemia-reperfusion have been demonstrated but there is paucity of information on these effects on the testes with implications on fertility which was investigated in this study. Fifteen adult male Wistar rats were used for this study. Group A was the control in which a sham laparatomy was done, Group B, in which intestinal ischaemia- reperfusion was set up and C in which splenectomy was done before setting up intestinal ischaemia-reperfusion by clamping the superior mesenteric artery. The ishaemia was for an hour and reperfusion also for an hour. Following reperfusion, portions of the intestines, epididymis and testes were harvested. Histomorphometry of intestines revealed a villus height of 93.98µm, 91.44µm, and 110.48µm in control, intestinal ischaemia-reperfusion and splenectomised rats and villi width of 24.5µm, 24.6µm and 38.5µm respectively. Testicular histomorphometry revealed seminal tubular diameter as189µm, 197µm and 215µm and luminal diameter of 58µm, 59µm and 62µm. Histopathology revealed congestion, desquamation and defoliation of germinal epithelium in all three groups but control rats had sperm cells present. In IIR group tubular damage and oedema were present and sperm cells were absent but in splenectomised rat, sperm cells were present in some tubules and absent in others but no tubular damage was observed. Splenectomy does exert a protective effect on intestinal ischaemia-reperfusion by moderating the effects in remote organs, as seen in testes.An erratum was issued for Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis. The author list was updated. The author list was updated from Eleftheria Saplaoura1, Valentina Perrera2, Friedrich Kragler1 1Max Planck Institute of Molecular Plant Physiology 2Department of Molecular Medicine, Medical School, University of Padua to Eleftheria Saplaoura1, Valentina Perrera2, Vincent Colot3, Friedrich Kragler1 1Max Planck Institute of Molecular Plant Physiology 2Department of Molecular Medicine, Medical School, University of Padua 3Biologie de l'Ecole Normale Supérieure (IBENS), Paris, France.A high prevalence of adolescent substance use, risky consumption patterns and the decrease in the age of initiation, together with the growth of non-substance addictions, represent a huge challenge for Public Health. This suggests the need for a change of focus in the work of the primary care settings, which must be more proactive in the early detection and intervention. Although there are some previous experiences in Spain, we do not have a duly standardised system, based on clinical practice and validated in consulting rooms, which could be used in a general, simple, and guaranteed manner. The SBIRT (Screening, Brief Intervention and Referral to Treatment) model, developed in the United States and conceived from a Public Health perspective, might represent such a paradigm shift. The aim of this paper was to provide researchers and professionals with a review of the available evidence in different countries, with a view to implementing it in Spain, where SBIRT remains a challenge. In addition, theoretical and technical foundations, and potential of the SBIRT are described. Not only its possible benefits and opportunities are put on the table, but also the shortcomings, limitations and needs that must be overcome for SBIRT implementation to be possible.

To compare the visual outcomes after prompt pars plana vitrectomy (PPV) with tap biopsy and intravitreal antimicrobial injection (TAI) to treat post-injection and post-surgery endophthalmitis.

The Cochrane Central Register of Controlled Trials, OVID MEDLINE, and OVID Embase databases were searched for manuscripts published between January 2010 to November 2020. Two independent reviewers selected papers and extracted data. We analyzed data in RevMan 5.3 and assessed methodological quality using the Cochrane ROBINS-I tool. Mean improvement in visual outcome was compared between PPV and TAI as a relative risk of improving >= 2 lines, and a mean LogMAR difference in improvement.

15 retrospective case-series (1355 eyes), of which 739 (55%) received TAI and 616 (45%) PPV as initial treatment were included. The overall relative risk of improving 2 or more lines in PPV in comparison to TAI was 1.04 (95% CI 0.88-1.23; p=0.61; I2=0%) with a mean difference of 0.04 (95% CI -0.18-0.27; p=0.69; I2=0%). The results stayed robust when subgroup analysis based on causative procedure for endophthalmitis was performed.

TAI is non-inferior to PPV for the treatment of post-cataract operation, post-injection, and post-pars plana vitrectomy endophthalmitis.

TAI is non-inferior to PPV for the treatment of post-cataract operation, post-injection, and post-pars plana vitrectomy endophthalmitis.

we propose a new releasable 8.0 polypropylene suture for leaking sclerotomies at the end of vitrectomy. Characteristic of this suture is that it can be easily removed the day after surgery at the slit lamp.

Patients undergoing 23 gauge pars plana vitrectomy (PPV) with the need for at least 2 sclerotomy sutures and having preoperative OSDI score <12 were consecutively allocated to sealing with either polyglactin 910 absorbable suture (VY GROUP) or non-absorbable 8.0 polypropylene releasable suture (PR GROUP). Evaluation of adverse events, OSDI score and conjunctival hyperemia (through Efron scale) was performed at 1, 7 and 30 days postoperatively.

Both methods effectively sealed sclerotomies. PR GROUP showed significantly lower OSDI score and lower degree of conjunctival hyperemia at both 7 and 30 days follow up. OSDI score decreased significantly after 7 days in PR GROUP while VY GROUP improved at 30 days postoperatively. PR GROUP showed a lower degree of conjunctival hyperemia both at 7 and 30 days follow up.

Polypropylene 8.0 releasable suture proved to be effective in 23 gauge PPV wound sealing while inducing less ocular surface inflammation and patient discomfort compared to standard polyglactin 910 suture.

Polypropylene 8.0 releasable suture proved to be effective in 23 gauge PPV wound sealing while inducing less ocular surface inflammation and patient discomfort compared to standard polyglactin 910 suture.

To examine hypotony-associated foveal lesions (FovLs) utilizing optical coherence tomography and to assess risk factors of visual deterioration after glaucoma filtering surgery.

Parameters that may be associated with post-surgical deterioration of visual acuity were retrospectively studied in 44 eyes of 44 patients who experienced post-surgical intraocular hypotension ≤6 mmHg between 2015 and 2019.

Six eyes (14%) had FovLs, such as detachment of photoreceptors (five eyes, 11%) and acquired vitelliform lesions (one eye, 2%) at 3 months after trabeculectomy. Logistic regression analysis revealed that hypotony maculopathy (P=0.0141 at 3 months) and FovLs (P=0.0486 and 0.0296 at 3 and 12 months, respectively) were significant risk factors for VA loss after trabeculectomy. The FovLs were located just behind the Müller cell cone (MCC). Visual acuity at 3 and 12 months after surgery in patients with FovLs was significantly lower than in those without FovLs (P=0.0013 and P=0.006, respectively). Epiretinal membrane was more common in eyes with FovLs (5 of 6 eyes, 83%) than in eyes without FovLs (7 of 38 eyes, 18%; P=0.0037).

MCC-associated FovLs lead to long-lasting visual acuity loss after filtering surgery.

MCC-associated FovLs lead to long-lasting visual acuity loss after filtering surgery.

Radiation use in medicine has significantly increased over the last decade, and cardiologists are among the specialists most responsible for X-ray exposure. The present study investigates a broad range of aspects, from specific European Union directives to general practical principles, related to radiation management among a national cohort of cardiologists.

A voluntary 31-question survey was run on the Italian Arrhythmology and Pacing Society (AIAC) website. From June 2019 to January 2020, 125 cardiologists, routinely performing interventional electrophysiology, participated in the survey. Eighty-seven (70.2%) participants are aware of the recent European Directive (Euratom 2013/59), although only 35 (28.2%) declare to have read the document in detail. Ninety-six (77.4%) participants register the dose delivered to the patient in each procedure, in 66.1% of the cases both as fluoroscopy time and dose area product. Years of exposition (P = 0.009) and working in centers performing pediatric procedures (P = 0.