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05). Mean radiation dose at level Ⅳ, thyroid and cervical esophagus showed significant difference between the 2 therapeutic groups (p < 0.01). As regard radiation complications, no significant difference was found in radiation dermatitis of any grade between the 2 groups (p > 0.05). However, there was remarkable difference in clinical hypothyroidism and radiation esophagitis between Group A and Group B (p < 0.05).

Radiotherapy after surgery omitting level Ⅳ may improve the quality of life in patients with locally advanced supraglottic and glottic laryngeal carcinoma, won't worsen the prognosis as well.

Radiotherapy after surgery omitting level Ⅳ may improve the quality of life in patients with locally advanced supraglottic and glottic laryngeal carcinoma, won't worsen the prognosis as well.

Cancer is associated with genetic variants of DNA repair genes that alter DNA repair capacity. The aim of this meta-analysis was to evaluate the relations between the rs13181 and rs1799793 XPD gene polymorphisms and risk for hepatocellular carcinoma (HCC) and gastric cancer.

Relevant publications were systematically sought from Web of Science, Pubmed, and China Academic Journals Full-text Database. The selection of eligible studies was performed by 2 independent authors. A total of 32 case-control studies were included. Meta-analyses were undertaken in all study participants and each ethnic group.

The risk of HCC was significantly increased with the XPD rs13181 G allele (P = 0.028, pooled odds ratio (OR) = 1.36, 95% confidence interval (CI) = 1.03-1.80) in all study participants. A subgroup analysis by ethnicity showed that the association was significant in Chinese (P = 0.009, pooled OR = 1.49, 95% CI = 1.11-2.02), but not in Caucasians (P = 0.619, pooled OR = 1.17, 95% CI = 0.64-2.13). Meta-analysis of the XPD rs1799793 polymorphism and HCC showed an association between its variant T allele and increased HCC risk in all study participants (P = 0.017, pooled OR = 1.23, 95% CI = 1.04-1.46, all Chinese). Our results showed no associations between the XPD rs13181 G allele and rs1799793 T allele and gastric cancer risk (rs13181 P = 0.298, pooled OR = 1.10, 95% CI = 0.92-1.31; rs1799793 P = 0.068, pooled OR = 1.31, 95% CI = 0.98-1.74).

This meta-analysis demonstrated that the XPD rs13181 G allele and rs1799793 T allele have significant associations with HCC and may be risk factors for HCC in the Chinese population. Current evidence indicated that they are not related to gastric cancer risk.

This meta-analysis demonstrated that the XPD rs13181 G allele and rs1799793 T allele have significant associations with HCC and may be risk factors for HCC in the Chinese population. Current evidence indicated that they are not related to gastric cancer risk.To acquire language, infants must learn to segment words from running speech. Bcl-2 apoptosis A significant body of experimental research shows that infants use multiple cues to do so; however, little research has comprehensively examined the distribution of such cues in naturalistic speech. We conducted a comprehensive corpus analysis of German child-directed speech (CDS) using data from the Child Language Data Exchange System (CHILDES) database, investigating the availability of word stress, transitional probabilities (TPs), and lexical and sublexical frequencies as potential cues for word segmentation. Seven hours of data (~15,000 words) were coded, representing around an average day of speech to infants. The analysis revealed that for 97% of words, primary stress was carried by the initial syllable, implicating stress as a reliable cue to word onset in German CDS. Word identity was also marked by TPs between syllables, which were higher within than between words, and higher for backwards than forwards transitions. Words followed a Zipfian-like frequency distribution, and over two-thirds of words (78%) were monosyllabic. Of the 50 most frequent words, 82% were function words, which accounted for 47% of word tokens in the entire corpus. Finally, 15% of all utterances comprised single words. These results give rich novel insights into the availability of segmentation cues in German CDS, and support the possibility that infants draw on multiple converging cues to segment their input. The data, which we make openly available to the research community, will help guide future experimental investigations on this topic.

Hypertension is often associated with obesity. Uncontrolled hypertension can lead to uncorrected cardiac dysautonomia that makes cardiac repolarization abnormally prolonged. Modern dietary habits, stress and bad life style habits makes young adults vulnerable to hazards of health.

So we planned to study the association of BMI (Body Mass Index) and BP ( Blood pressure) with QTc (corrected QT interval) in young adults.

After obtaining the written informed consent, 171 subjects were randomly selected in the age group of 18-35 years. A general history and physical examination was done before recording the BMI and BP. A 12 lead ECG was recorded and QTc calculated using Bazett's formula. The values obtained were compared and statistical analysis done.

Of the 171 subjects 14.03% were hypertensive. The QTc interval is found to be prolonged in females and it is prolonged with age, BMI and BP.

QTc was significantly increased among the prehypertensive and hypertensive group and with overweight / obese BMI group compared to the normotensives and normal BMI group suggesting an altered autonomic homeostasis. This warrants lifestyle modification at a younger age to reduce the cardiovascular risk.

QTc was significantly increased among the prehypertensive and hypertensive group and with overweight / obese BMI group compared to the normotensives and normal BMI group suggesting an altered autonomic homeostasis. This warrants lifestyle modification at a younger age to reduce the cardiovascular risk.This study examined the influences of perceived distance to communicator on the effects of aggressive style (i.e. personal attacks and intense languages) in communicating scientific issues such as COVID-19 to the public. With a multi-site experiment (N = 464), we found that aggression led to a heightened violation of expected social norm regarding communication styles. However, the interpretation of violation varied depending on the individual's perceived distance to the communicator. Close distance articulated the urgency and severity of COVID-19 risks conveyed with aggression, which further increased compliance with the message. Far distance perception amplified aggression's negative influence on writer likeability. The findings showed that aggressive communication may generate positive outcomes when dealing with public understanding of scientific issues such as COVID-19, but communicators need to build a closer connection with their audience.