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4%) entered the open-label extension (age, years 9 [n = 1], 12 [n = 2], 13 [n = 7], 14 and 15 [n = 9 each], 16 [n = 10]). The safety profile observed was similar to the double-blind trials. Most TEAEs (>95%) were mild/moderate, related to anticholinergic activity, and infrequently led to discontinuation (n = 1/38 [2.6%]). No pediatric patients experienced a serious TEAE. Most anticholinergic TEAEs did not require a dose modification and resolved within 7 days. selleck chemicals llc Approximately, one-third of patients (n = 13/38 [34.2%]) had LSRs; most were mild/moderate in severity. Improvements in efficacy measures were maintained from the double-blind trials. CONCLUSIONS Long-term, once-daily GT for up to 48 weeks (4-week double-blind plus 44 week open label) provides a noninvasive, well-tolerated treatment option for pediatric patients with primary axillary hyperhidrosis. © 2020 The Authors. Pediatric Dermatology published by Wiley Periodicals, Inc.Using a minimalist approach, an 11-residue peptide (Peptide 1) tagged with rhodamine fluorophore was designed and synthesized for selective detection of cancer cells. Peptide 1 contains RGD and NGR motifs to bind, respectively, integrins and aminopeptidase CD13, which are over expressed in cancer cells. Surface tension measurements revealed that peptide 1 possess surface active property owing to the overall hydrophobicity and cationic nature of the peptide. Peptide 1 displays cancer cell selective binding at ≤5.0 µM concentrations, while peptide 2 (randomized sequence of 1) shows non-selective binding to normal and cancer cells. Fluorescence microscopy and FACS analysis demonstrated the intracellular localization of peptide 1 in three different cancer cell lines, confirming the role of RGD and NGR motifs. Cytotoxicity assay exhibited the viability of normal and cancer cells up to 100 µM concentrations of peptide 1. Steady state fluorescence measurements disclosed the preferential interactions of the peptide 1 with anionic POPC/POPG bilayers rather than with zwitterionic POPC lipid bilayers. Circular dichroism studies showed minimal changes in the secondary structure of peptide 1 upon binding with the anionic lipid bilayers. Peptide 1 is largely unordered, non-toxic, and useful for identification of cancer cells. Peptide 1 provides a template for designing drug-loaded peptides for targeted delivery into cancer cells. This article is protected by copyright. All rights reserved.BACKGROUND There are limited data on the association between uric acid (UA) and symptomatic intracranial haemorrhage (SICH) in patients who have undergone mechanical thrombectomy (EVT). In the present study, we aimed to investigate the role of serum UA level in SICH after EVT in a real-world practice. METHODS Patients were selected from the Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke Registry (ACTUAL). SICH was identified using the Heidelberg Bleeding Classification. Multivariable logistic regression analysis was performed to explore the relationship between serum UA and SICH. RESULTS Among 611 enrolled patients, 90 (14.7%) were diagnosed with SICH within 72 hours after EVT. Patients with SICH had a significantly higher level of serum UA (median, 341.0 μmol/L versus 302.0 μmol/L; P = 0.003) than those without SICH. Univariate logistic regression analysis indicated that patients with UA levels in the fourth quartile, compared with the first quartile, were more likely to have SICH (odds ratio, 2.846; 95% confidence interval, 1.429-6.003; P = 0.003). The association remained significant after multivariable adjustment for potential confounders. Furthermore, the multiple-adjusted spline regression model showed an inverted U-shape association between UA and SICH (P = 0.047 for nonlinearity). CONCLUSION Our study indicated that increased serum UA level was independently associated with SICH after EVT in acute ischemic stroke. This article is protected by copyright. All rights reserved.PURPOSE To assess the effect of tooth preparation design on fracture resistance of zirconia-reinforced lithium silicate overlays. MATERIALS & METHODS This study evaluated 50 human maxillary first molars with no caries, restorations or anatomical defects. The teeth were randomly divided into five groups (n = 10/group) based on preparation design for the fabrication of overlay restorations (O) anatomical occlusal reduction, (OS) anatomical occlusal reduction with round shoulder preparation, (OG) anatomical occlusal reduction with a central groove, (OSG) anatomical occlusal reduction with round shoulder preparation and central groove, and (C) no preparation of tooth (control group). All restorations were fabricated using zirconia-reinforced lithium silicate (Vita Suprinity). The specimens underwent thermomechanical fatigue loading in a masticatory simulator (1.2 million cycles at 98 N). Fracture resistance was measured using a universal testing machine. The mode of failure was determined as well. Data were analyzed using one-way ANOVA followed by Tukey's post-hoc test, paired t-test and Fisher's exact test (α = 0.05). RESULTS Group O showed significantly higher fracture resistance than groups OG and OSG (P = 0.002 and P = 0.001, respectively). The fracture resistance of group OS was significantly higher than that of group OSG (P = 0.008). The fracture resistance of the control group was significantly higher than that of OG and OSG (P = 0.001) and had no significant difference with other groups. CONCLUSIONS Group O (anatomical occlusal reduction alone), which had the most conservative preparation design, yielded the highest fracture resistance. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.AIM To investigate pro-environmental health perceptions, behaviour and educational needs among pregnant women in Korea. BACKGROUND Based on concerns about the effects of environmental hazards and pollution on their babies and themselves, pregnant women behave in ways that protect their health. The framework of this study was based on Rogers' protection motivation theory. DESIGN Cross-sectional survey using questionnaires. METHOD The sample comprised 358 pregnant women recruited from July - August 2018 in South Korea. Participants were recruited from prenatal classes at two healthcare centres and patients receiving prenatal check-ups at two women's hospitals. RESULTS Perceived educational needs were ranked in the following order particulate matter (23.7%), electromagnetic waves (11.7%), instant food (food additives) (9.0%) and environmental hormones (8.3%). Age (β = 0.17, p = .001), perceived severity (β = 0.19, p = .001) and response efficacy (β = 0.28, p  less then  .001) affected pro-environmental behaviour, which explained 23.