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In summary, loss of endothelial HA results in impaired microvascular perfusion and endothelial stability in ischemic gastrocnemius muscle. Endothelial HA is a potential target to improve angiogenic therapy in diabetic patients with critical limb ischemia.The role of infections in the pathogenesis of autism spectrum disorder (ASD) is still controversial. In this study, we aimed to evaluate markers of infections and immune activation in ASD by performing a meta-analysis of publicly available whole-genome transcriptomic datasets of brain samples from autistic patients and otherwise normal people. Among the differentially expressed genes, no significant enrichment was observed for infectious diseases previously associated with ASD, including herpes simplex virus-1 (HSV-1), cytomegalovirus and Epstein-Barr virus in brain samples, nor was it found in peripheral blood from ASD patients. Interestingly, a significant number of genes belonging to the "prion diseases" pathway were found to be modulated in our ASD brain meta-analysis. Overall, our data do not support an association between infection and ASD. However, the data do provide support for the involvement of pathways related to other neurodegenerative diseases and give input to uncover novel pathogenetic mechanisms underlying ASD.Tea (Camellia sinensis) is an important food product with thousands of years of human use. Being a non-washable food, no pesticide residues are allowed, which increases the importance of natural means of plant protection. Predation, a component of natural pest control, is an important contributor to this, but its level and sustainability are not known in most of the areas of tea production. We quantified predation intensity using the artificial sentinel prey method in a tea-growing landscape containing remnants of the original forest vegetation in Fujian Province, China. The most common predators were chewing arthropods (49.8% of predation events) and birds (48.1%). Overall, predation rates at the edges of forest fragments (18.9% d-1) were lower than either in fragment interiors (25.4%d-1) or in the surrounding tea plantations (19.2-24.1%d-1). Arthropod predation was higher inside, and at the edge of, forest fragments than within plantations, and generally decreased with increasing distance from a fragment edge, indicating limited spillover of arthropod predators from the native habitat remnants to the cultivated matrix at the local scale. Irbinitinib cell line Bird predation, though, showed a different trend it was lower on the inside of forest fragments than in the tea planation, and bird attack rates increased at increasing distances (up to 40 m) from the forest fragment edge. We also found a reciprocal relationship between attack rates by birds and arthropods, suggesting intra-guild predation. Measures protecting arthropod natural enemies could increase the combined pest suppression effect, contributing to pesticide-free tea production in China.Polymeric micelles based on amphiphilic polysaccharides have some advantages as a carrier of poorly soluble lipophilic drugs thanks to their characteristic "core-shell" structure. Previously, ionic polymeric micelles based on chitosan and fatty acids have been developed. The aim of the present study was the preparation and characterization of hyaluronic acid (HA) derivatives by direct ionic interaction between the HA carboxylic groups and the amine groups of dodecyl amine (DDA) and hexadecyl amine (HDA). The HA-HDA polymeric micelles were loaded with a poorly soluble hydrophobic antifungal drug, clotrimazole (CLO). A 23 full factorial experimental design was used to evaluate the effect of the following factors HA/HDA ratio from 10.25 to 10.75, cholesterol (CHOL%) as percentage of HA from 10% to 30%, and preparation temperature from 20 to 40 °C. As dependent variables (responses), nanoparticle dimensions and clotrimazole concentration in the final colloidal dispersion were considered. To optimize the drug final concentration, the design was therefore expanded into a rotatable central composite design (CCD). The effects of the formulation variables and the composition of the optimized formulation were confirmed by a mixture design. Physicochemical characterization of the optimized formulation was performed, confirming the ionic interaction between the polysaccharide and the HDA.A proposition addressed here is that, although bitted horses are viewed by many equestrians as being largely free of bit-related mouth pain, it seems likely that most behavioural signs of such pain are simply not recognised. Background information is provided on the following the major features of pain generation and experience; cerebrocortical involvement in the conscious experience of pain by mammals; the numerous other subjective experiences mammals can have; adjunct physiological responses to pain; some general feature of behavioural responses to pain; and the neural bases of sensations generated within the mouth. Mouth pain in horses is then discussed. The areas considered exclude dental disease, but they include the stimulation of pain receptors by bits in the interdental space, the tongue, the commissures of the mouth, and the buccal mucosa. Compression, laceration, inflammation, impeded tissue blood flow, and tissue stretching are evaluated as noxious stimuli. The high pain sensitivity of the interdenving rise to suffocating experiences of breathlessness. In addition, breathlessness is a likely consequence of the low jowl angles commonly maintained during dressage. If severe, as with pain, the prospect of breathlessness is likely to give rise to anxiety and the direct experience of breathlessness to fear. The related components of welfare compromise therefore likely involve pain, breathlessness, anxiety, and fear. Finally, a 12-point strategy is proposed to give greater impetus to a wider adoption of bit-free bridles in order to avoid bit-induced mouth pain.The research of innovative methodologies to improve the Aluminium alloys formability at room temperature still remains an open question the local modification of the material properties via short-term heat treatments followed by the stamping at room temperature is reported to be an effective alternative to the forming in warm conditions. In the present work, such a methodology has been applied to the deep drawing of an age-hardenable Aluminium alloy (AA6082-T6) using an experimental/numerical approach. A preliminary extensive material characterization was aimed at investigating the material behaviour (i) in the as-received condition (peak hardening), (ii) in the supersaturated condition (obtained by physical simulation) and (iii) after being locally solutioned via laser heating. A Finite Element based approach (Abaqus CAE, v. link2 6.17) was then used to design the laser treatment of the blanks to be subsequently deep drawn at room temperature a 2D axisymmetric model of the deep drawing process was coupled with the optimization platform modeFRONTIER in order to define the radial extent of the laser heat treated area able to maximize the Limit Drawing Ratio. The experimental tests were finally conducted for validation purposes and revealed the effectiveness of the adopted approach which allowed to improve the drawability of more than 20% with respect to the as received condition (T6).In the current call for a greater human health and well-being as a sustainable development goal, to encourage active commuting to and from school (ACS) seems to be a key factor. Research focusing on the analysis of the association between environmental factors and ACS in children and adolescents has reported limited and inconclusive evidence, so more knowledge is needed about it. The main aim of this study is to examine the association between different built environmental factors of both school neighbourhood and home-school route with ACS of children and adolescents belonging to urban areas. The ACS level was evaluated using a self-reported questionnaire. Built environment variables (i.e., density of residents, street connectivity and mixed land use) within a school catchment area and home-school route characteristics (i.e., distance and pedestrian route directness-PRD) were measured using a geographic information system (GIS) and examined together with ACS levels. Subsequently, the association between envirtogether with the environmental factors using GIS separately for children and adolescents can inform future friendly and sustainable communities.This Special Issue "Sustainable Designed Pavement Materials" has been proposed and organized as a means to present recent developments in the field of environmentally-friendly designed pavement materials. For this reason, articles included in this special issue relate to different aspects of pavement materials, from industry solid waste recycling to pavement materials recycling, from pavement materials modification to asphalt performance characterization, from pavement defect detection to pavement maintenance, and from asphalt pavement to cement concrete pavement, as highlighted in this editorial.BACKGROUND The aim of this pilot study was to compare the efficacy of hydroponically cultivated red Panax ginseng Meyer root preparation (HRG80) and traditionally harvested six-year-old white P. ginseng standard preparation (PGS) with placebo in preventing symptoms of stress. METHODS The effects of HRG80, PGS, and placebo capsules were studied in 50 tired healthy subjects in a three-arm, randomized, double-blinded, placebo-controlled crossover trial. Efficacy-outcome measures included the accuracy of processing the d2 test for cognitive functions, obtained accuracy score in a computerized memory test, and the perceived-stress (PS) score. RESULTS A statistically significant interaction effect between time and treatment (p less then 0.0001) was observed in the attention d2 and memory tests, indicating that HRG80 treatment was more beneficial than that with a placebo. The effects of PGS were better than those of the placebo, but the difference was not statistically significant. There was significant difference between the effects of HRG80 and PGS (p less then 0.0001) that were observed after single (Day 1) and repeated administrations on Days 5 and 12 of treatment. link3 CONCLUSION Overall, HRG80 treatment was significantly superior compared to that with the PGS and placebo regarding attention, memory, and PS scores after single and repeated administrations for 5 and 12 days.For the purpose of providing transducers for long-term monitoring of wall thinning of critical pressure equipment in corrosion or high temperature environments, the optimal design methodology for tapered waveguide units was proposed in the present study. Firstly, the feasibility of the quasi-fundamental shear horizontal (SH0*) wave propagating in the tapered waveguide units was analyzed via numerical simulations, and the transmitting limitations of the non-dispersive SH0* wave were researched. Secondly, several tapered waveguide transducers with varying cross-sections to transmit pure SH0* wave were designed according to the numerical results. Experimental investigations were carried out, and the results were compared with waveguide transducers with a prismatic cross-section. It was found that the tapered waveguide units can transmit non-dispersive shear horizontal waves and suppress the wave attenuation at the same time. The experimental results agreed very well with the numerical simulations. Finally, high-temperature experiments were carried out, and the reliability of thickness measuring by the tapered waveguide transducers was validated.