Sinclairchristensen7315

Sneezing was observed from day 22 to 28. The rats were sacrificed on day 22 and day 28. The expression of CD4+ CD25+ Foxp3+ in Treg and plasma cells was analyzed by flow cytometry assay.

This study showed that the percentage of plasma cell and sneezing times significantly decreased in MSCs treatment. This finding was aligned with the significant increase of CD4+CD25+Foxp3+ Treg level.

MSCs administration suppress plasma cells population and sneezing times by up regulating Treg to control AR.

MSCs administration suppress plasma cells population and sneezing times by up regulating Treg to control AR.

Although scientometry gradually became prevalent way of measuring one's research output, there are many inherent drawbacks in main indices that are used impact factor, number of citations, number of published papers and Hirsch's index.

The aim of this study was to analyze effects of inflated co-authorship on values of scientometric indices among authors in biomedicine who participated in published papers with more than 30 co-authors.

The study was of cross-sectional type, based on 100 publications randomly extracted from the MEDLINE database. The inclusion criterion was publication with more than 30 authors. The studies with topics not related to humans were excluded from further analysis.

On average about 10% of papers published by the surveyed authors had more than 30 co-authors, but these papers brought more than 40% of all citations and more than 40% of Hirsch's index attributed to these authors. The duration of scientific activity was well correlated to number of citations, Hirsch's index and theevent unjustified co-authorship if it reflects the work invested in a research result.

Some birds cover their eggs with nest material when they leave to forage. It has been suggested that such egg-covering aids thermoregulation or prevents predation but here we present a new hypothesis, that secondary cavity-nesting species cover their eggs to prevent nest usurpation by other birds. When the bottom of the cavity is dark, as when eggs are covered by nest material, it may be difficult for a prospecting competitor to see whether a defending nest owner or a predator is hiding inside the cavity. Competitors may therefore hesitate to enter dark cavities. We filmed 21 great tit (

) nests during the egg-laying period and found that the female spent bouts of highly variable length outside the nest box (range 0.3-250min,

 = 51), so prospecting small passerines would have difficulty predicting whether an aggressive tit owner was in the box or would soon return. We presented prospecting male pied flycatchers (

) with a dyad of boxes (

 = 93), each containing a great tit nest but only one with visiblhers hesitated to enter dark cavities with dark floors relative to boxes with exposed, reflective eggs.Ultra-short pulsed laser ablation enables a defined generation of micro-holes. A parameter study on the ablation characteristics of copper clearly reveals a benefit for green wavelength with lower threshold fluence, simultaneously increasing the Rayleigh length. The use of a circular drilling method allows a defined manufacturing of micro boreholes and micro through-holes with 35 μm diameter of up to 165 μm and 300 μm length. Introducing high-resolution micro-computed X-ray tomography studying the micro-hole evolution and adjacent geometrical transformations reveals micrometer resolution and high usability. The conical geometry evolving up to an aspect ratio of 51 fits well to established models known for percussion drilling. However, increasing the number of pulses leads to non-conical geometry evolution, and this resulting geometry is studied for the first time. Henceforth, the exact geometrical evolution from conical to cylindrical shape upon laser drilling can be resolved revealing the impact of multiple reflections at the generated steep flanks.Diamond wire sawing has obtained 90% of the single-crystal silicon-based photovoltaic market, mainly for its high production efficiency, high wafer quality, and low tool wear. The diamond wire wear is strongly influenced by the temperatures in the grain-workpiece contact zone; and yet, research studies on experimental investigations and modeling are currently lacking. In this direction, a temperature model is developed for the evaluation of the flash temperatures at the grain tip with respect to the grain penetration depth. An experimental single-grain scratch test setup is designed to validate the model that can emulate the long contact lengths as in the wire sawing process, at high speeds. Furthermore, the influence of brittle and ductile material removal modes on cutting zone temperatures is evaluated.Especially for slicing hard and brittle materials, wire sawing with electroplated diamond wires is widely used since it combines a high surface quality with a minimum kerf loss. Furthermore, it allows a high productivity by machining multiple workpieces simultaneously. During the machining operation, the wire/workpiece interaction and thus the material removal conditions with the resulting workpiece quality are determined by the material properties and the process and tool parameters. However, applied to machining of carbon fibre reinforced polymers (CFRP), the process complexity potentially increases due to the anisotropic material properties, the elastic spring back potential of the material, and the distinct mechanical wear due to the highly abrasive carbon fibres. Selleck CDK inhibitor Therefore, this experimental study analyses different combinations of influencing factors with respect to process forces, workpiece surface temperatures at the wire entrance, and the surface quality in wire sawing unidirectional CFRP material. As main influencing factors, the cutting and feed speeds, the density of diamond grains on the wire, the workpiece thickness, and the fibre orientation of the CFRP material are analysed and discussed. For the tested parameter settings, it is found that while the influence of the grain density is negligible, workpiece thickness, cutting and feed speeds affect the process substantially. In addition, higher process forces and workpiece surface temperatures do not necessarily deteriorate the surface quality.Consider a critical branching random walk on Z d , d ≥ 1 , started with a single particle at the origin, and let L(x) be the total number of particles that ever visit a vertex x. We study the tail of L(x) under suitable conditions on the offspring distribution. In particular, our results hold if the offspring distribution has an exponential moment.To improve soil health and to aid in climate change mitigation, the quantity of soil organic matter (SOM) should be maintained or increased over the long run. In doing so, not only the total quantity of SOC but also the stability of SOC must be considered. Stability of SOC increases as a function of resistance to microbial decomposition or microbial substrate use efficiency through chemical, biological, and physical mechanisms including humification, hydrophobic moieties, molecular diversity, and formation of macroaggregates. One of the mechanisms that enhance stability confers changes in the distribution of C functional groups of SOM. To better understand and quantify how these changes are influenced by agricultural management practices, we collected 670 pairwise data from the body of literature that has evaluated changes in the distribution of C functional groups of SOM measured by solid-state 13C NMR spectroscopy. The types of agricultural managements discussed herein include (1) fertilization, (2) tillage, (3) crop rotation, (4) grazing, and (5) liming practices. Our meta-analyses show that these practices modify the distribution of C functional groups of SOM. Fertilization practices were associated with increased O-alkyl groups. Tillage resulted in increases in the SOC consisted of aromatic and carbonyl groups. Crop rotations, especially legume-based rotations, were found to increase the proportion of aromatic groups. Although there are fewer publications on tillage and crop rotation than on fertilization practices, the distribution of C functional groups may be more influenced by crop rotation and tillage practices than fertilization management-and should be a focus of future research.

The online version contains supplementary material available at 10.1007/s00374-021-01580-2.

The online version contains supplementary material available at 10.1007/s00374-021-01580-2.Soil organic nitrogen (N) is a critical resource for plants and microbes, but the processes that govern its cycle are not well-described. To promote a holistic understanding of soil N dynamics, we need an integrated model that links soil organic matter (SOM) cycling to bioavailable N in both unmanaged and managed landscapes, including agroecosystems. We present a framework that unifies recent conceptual advances in our understanding of three critical steps in bioavailable N cycling organic N (ON) depolymerization and solubilization; bioavailable N sorption and desorption on mineral surfaces; and microbial ON turnover including assimilation, mineralization, and the recycling of microbial products. Consideration of the balance between these processes provides insight into the sources, sinks, and flux rates of bioavailable N. By accounting for interactions among the biological, physical, and chemical controls over ON and its availability to plants and microbes, our conceptual model unifies complex mechanisms of ON transformation in a concrete conceptual framework that is amenable to experimental testing and translates into ideas for new management practices. This framework will allow researchers and practitioners to use common measurements of particulate organic matter (POM) and mineral-associated organic matter (MAOM) to design strategic organic N-cycle interventions that optimize ecosystem productivity and minimize environmental N loss.

The online version contains supplementary material available at 10.1007/s10533-021-00793-9.

The online version contains supplementary material available at 10.1007/s10533-021-00793-9.Recent work has established a framework for explaining the origin of cognitive novelties-qualitatively distinct cognitive traits-in human beings. This niche construction approach argues that humans engineer epistemic environments in ways that facilitate the ontogenetic and phylogenetic development of such novelties. I here argue that attention to the organized relations between content-carrying informational vehicles, or informational form, is key to a valuable explanatory strategy within this project, what I call structural-causal explanations. Drawing on recent work from Cecilia Heyes, and developing a case study around a novel mathematical capacity, I demonstrate how structural-causal explanations can contribute to the niche construction approach by underwriting the application of explanatory tools and generating new empirical targets.Scientists often think of the world (or some part of it) as a dynamical system, a stochastic process, or a generalization of such a system. Prominent examples of systems are (i) the system of planets orbiting the sun or any other classical mechanical system, (ii) a hydrogen atom or any other quantum-mechanical system, and (iii) the earth's atmosphere or any other statistical mechanical system. We introduce a general and unified framework for describing such systems and show how it can be used to examine some familiar philosophical questions, including the following how can we define nomological possibility, necessity, determinism, and indeterminism; what are symmetries and laws; what regularities must a system display to make scientific inference possible; how might principles of parsimony such as Occam's Razor help when we make such inferences; what is the role of space and time in a system; and might they be emergent features? Our framework is intended to serve as a toolbox for the formal analysis of systems that is applicable in several areas of philosophy.