Sigmontrue4339

Nature-based solutions (NBS), understood as actions that use ecosystem processes to address societal needs, can play important roles to future-proof river landscape development for people and nature. However, knowledge gaps exist how NBS can be planned and implemented at landscape scales. This Special Issue brings together insights and experiences from studies of assessing, planning, and implementing NBS in river landscapes in Europe and beyond. It addresses three research fields (i) NBS effects, looking at the effectiveness of NBS to achieve ecological, social, and/or economic outcomes, (ii) NBS planning, focusing on approaches for planning and designing NBS, and (iii) NBS governance, relating to governance and business models for implementation. The twelve contributions deliver evidence on how NBS outperform conventional, rather technical solutions, provide guidance and tools to operationalize the NBS concept into practice, and showcase successful governance models of NBS in different contexts. The editorial ends with an outlook on further research needs.The secretory phospholipase A2 (sPLA2) group of secreted enzymes hydrolyze phospholipids and lead to the production of multiple biologically active lipid mediators. sPLA2s and their products (e.g., eicosanoids) play a significant role in the pathophysiology of various inflammatory diseases, including life-threatening lung disorders such as acute lung injury (ALI) and the Acute Respiratory Distress Syndrome (ARDS). The ALI/ARDS spectrum of severe inflammatory conditions is caused by direct (such as bacterial or viral pneumonia) or indirect insults (sepsis) that are associated with high morbidity and mortality. Several sPLA2 isoforms are upregulated in patients with ARDS as well as in multiple ALI preclinical models, and individual sPLA2s exert unique roles in regulating ALI pathophysiology. This brief review will summarize the contributions of specific sPLA2 isoforms as markers and mediators in ALI, supporting a potential therapeutic role for targeting them in ARDS.In their fundamental paper, Luce, Steingrimsson, and Narens (2010, Psychological Review, 117, 1247-1258) proposed that ratio productions constituting a generalization of cross-modality matching may be represented on a single scale of subjective intensity, if they meet "cross-dimensional commutativity." The present experiment is the first to test this axiom by making truly cross-modal adjustments of the type "Make the sound three times as loud as the light appears bright!" Twenty participants repeatedly adjusted the level of a burst of noise to result in the desired sensation ratio (e.g., to be three times as intense) compared to the brightness emanating from a grayscale square, and vice versa. Cross-modal commutativity was tested by comparing a set of successive ×2×3 productions with a set of ×3×2 productions. When this property was individually evaluated for each of 20 participants and for two possible directions, i.e., starting out with a noise burst or a luminous patch, only seven of the 40 tests indicated a statistically significant violation of cross-modal commutativity. Cross-modal monotonicity, i.e. checking whether ×1, ×2, and ×3 adjustments are strictly ordered, was evaluated on the same data set and found to hold. Multiplicativity, by contrast, i.e., comparing the outcome of a ×1×6 adjustment with ×2×3 sequences, irrespective of order, was violated in 17 of 40 tests, or at least once for all but six participants. This suggests that both loudness and brightness sensations may be measured on a common ratio scale of subjective intensity, but cautions against interpreting the numbers involved at face value.In foraging tasks, multiple targets must be found within a single display. PARP inhibitor The targets can be of one or more types, typically surrounded by numerous distractors. Visual attention has traditionally been studied with single target search tasks, but adding more targets to the search display results in several additional measures of interest, such as how attention is oriented to different features and locations over time. We measured foraging among five age groups Children in Grades 1, 4, 7, and 10, as well as adults, using both simple feature foraging tasks and more challenging conjunction foraging tasks, with two target types per task. We assessed participants' foraging organization, or systematicity when selecting all the targets within the foraging display, on four measures Intertarget distance, number of intersections, best-r, and the percentage above optimal path length (PAO). We found that foraging organization increases with age, in both simple feature-based foraging and more complex foraging for targets defined by feature conjunctions, and that feature foraging was more organized than conjunction foraging. Separate analyses for different target types indicated that children's, and to some extent adults', conjunction foraging consisted of two relatively organized foraging paths through the display where one target type is exhaustively selected before the other target type is selected. Lastly, we found that the development of foraging organization is closely related to the development of other foraging measures. Our results suggest that measuring foraging organization is a promising avenue for further research into the development of visual orienting.

This review highlights the intersection of the COVID-19, HIV, and STI pandemics and examines how harm reduction strategies can be applied broadly to controlling a pandemic.

Since the onset of the COVID-19 pandemic, remarkable advances in the understanding of COVID-19 prevention, diagnosis, and treatment have been made at a much faster pace than prior pandemics, yet much more still remains to be discovered. Many of the strategies to control the COVID-19 pandemic mirror those employed to stem the HIV pandemic. Harm reduction principles used in the HIV pandemic can be applied to reduce the morbidity and mortality of the COVID-19 pandemic through effective prevention, detection, and treatment strategies.

Since the onset of the COVID-19 pandemic, remarkable advances in the understanding of COVID-19 prevention, diagnosis, and treatment have been made at a much faster pace than prior pandemics, yet much more still remains to be discovered. Many of the strategies to control the COVID-19 pandemic mirror those employed to stem the HIV pandemic. Harm reduction principles used in the HIV pandemic can be applied to reduce the morbidity and mortality of the COVID-19 pandemic through effective prevention, detection, and treatment strategies.While obesity is defined as an excessive fat accumulation conferring a risk to metabolic health, increased adipose mass by itself does not fully explain obesity's propensity to promote metabolic alterations. Adipose tissue regulates multiple processes critical for energy homeostasis and its dysfunction favors the development and perpetuation of metabolic diseases. Obesity drives inflammatory leucocyte infiltration in adipose tissue and fibrotic transformation of the fat depots. Both features associate with metabolic alterations such as impaired glucose control and resistance to fat mass loss. In this context, adipose progenitors, an heterogenous resident population of mesenchymal stromal cells, display functions important to shape healthy or unhealthy adipose tissue expansion. We, here, outline the current understanding of adipose progenitor biology in the context of obesity-induced adipose tissue remodeling.

Cigarette smoking remains a substantial public health problem. Nicotine replacement therapy (NRT) is an effective treatment that increases the success of a quit attempt. There are different NRT formats with no difference in efficacy, but their pharmaceutical form or route of administration may translate into individual preferences. A novel prototype mini lozenge was developed to offer smokers a new NRT option to aid in their quit attempt. Two studies were conducted to characterize the pharmacokinetic parameters and to evaluate its bioequivalence to a commercially available nicotine mini lozenge.

Two randomized, open-label, crossover studies were conducted to evaluate either the 2 or 4mg dose level. Heavy smokers in otherwise good health were randomly assigned to one of two treatment sequences the prototype mini lozenge followed by a commercially available mini lozenge, or the converse. After a 5 to 7day washout period, subjects crossed over to receive the other study treatment. Blood sampling occurred pregs.

The prototype mini lozenge is bioequivalent to a commercially available mini lozenge and may provide smokers with a new oral NRT option to aid in smoking cessation and of tobacco dependence through the relief of nicotine withdrawal symptoms, including cravings.

Cancer immunotherapy represents one of the most important innovations in modern medicine. Durvalumab is an anti-programmed cell death ligand1 (PDL-1) agent which is currently under investigation in several studies in combination with the anti-cytotoxic Tlymphocyte-associated protein4 (CTLA-4) drug tremelimumab. The aim of this review was to systematically identify and revise the current scientific literature investigating the combination of these two drugs in solid tumors.

A digital search on the Medline (PubMed interface) and Scopus databases for articles published from inception to 26 February 2021 was performed. The terms used for the search were durvalumab AND tremelimumab. Trials reported in English involving adult patients with solid cancers treated with the combination durvalumab plus tremelimumab were retrieved; the references of the articles were cross-checked to identify missing papers.

The electronic search produced 267 results; after exclusion of duplicates, irrelevant articles, reviews, ander cohorts are warranted.To report our experience in treating one patient with nontraumatic subarachnoid hemorrhage (SAH) and concurrent acute ischemic stroke (AIS) due to large vessels occlusion (LVO). A man in his 50 s presented with acute right hemiparesis and aphasia. Brain CT showed a SAH in the left central sulcus; CT-angiography revealed a tandem occlusion of the left internal carotid artery and homolateral middle cerebral artery. He underwent an angiographic procedure with successful recanalization. Follow-up CT demonstrated a striatal-lenticular stroke without SAH progression. While the absolute contraindication to IVT during intracranial bleeding remains unquestionable, the potential injury/benefit from MT is still debatable. Such cases constitute a blind spot in the guidelines where physicians face the dilemma of choosing between an acute endovascular treatment with the risks of hemorrhage progression and a conservative treatment with the associated poor clinical outcome. We decided to treat our patient invasively, considering the young age, also given the absence of prognostic factors that generally predict post-procedural reperfusion injury. We believe that, in similar cases, MT should be considered-despite not free of risks and drawbacks-to avoid the detrimental consequences of untreated AIS from LVO.This review is a brief summary of the history of the development of the Prothrombinase complex paradigm and its incorporation into the "extrinsic pathway". It summarizes my laboratory's research from 1968 to 2012 and identifies many of the key players in these efforts.