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005). The period of second-line treatment in the cooperative group was significantly longer (P=0.003) than that in the solo group, whereas the proportion of patients who subsequently received third-line treatment was higher in the cooperative group, 58. 5%, than in the solo and joint groups, 26. 5% and 25. 5%, respectively. Posttreatment QoL measurements in the joint and solo groups were significantly lower for 3 and 6 items, respectively, whereas there was no appreciable decrease in post-treatment QoL measurements in the cooperative group. Multivariate analysis showed that cooperative treatment was particularly beneficial for female patients ≥75 years of age, and patients with status 2 performance.This article highlights publications in Enviromental Microbiology and Microbial Biotechnology papers about antibiotic resistance. It concludes that the One health approach is basic to addressing this problem.Crested geckos (Correlophus ciliatus, formerly Rhacodactylus ciliatus) were rediscovered in New Caledonia 25 years ago and despite being common in the pet trade, there is no published information on their physiology. We measured thermoregulation (preferred body temperature, thermal set-point range, and voluntary limits) and performance (thermal performance curves [TPC] for 25 cm sprint speed and 1 m running speed) of adult and juvenile crested geckos in the laboratory to describe their thermal tolerances, differences among life stages, correlations between behavior and performance, and correlations with natural temperatures. Despite lacking special lighting or heating requirements in captivity, crested geckos displayed typical thermal biology for a lizard with no difference among life stages. They thermoregulated to a narrow set-point range (TSET , 24-28°C), that broadly overlaps natural air temperatures in New Caledonia, during activity. Somewhat surprisingly, the optimal temperature for performance (TOPT , 32°C) was substantially above preferred body temperatures and approximated the average maximum temperature voluntarily experienced (VTMAX , 33°C). Preferred body temperatures, by contrast, corresponded to the lower threshold temperature (Td ) where the TPC deviated from exponential, which we suggest is the temperature where performance is optimized after accounting for the costs of metabolic demand and overheating risk. Our results demonstrate that despite their lack of specific requirements when housed in human dwellings, crested geckos actively thermoregulate to temperatures that facilitate performance, and have thermal biology typical of other nocturnal or shade-dwelling species. Additionally, crested geckos appear at little risk of direct climate change-induced decline because increased temperatures should allow increased activity.Objectives To evaluate postoperative pain and esthetic outcomes in patients undergoing transumbilical laparoscopic adrenalectomy with wound closure using 2-octyl cyanoacrylate. Methods A total of 26 patients who underwent laparoscopic adrenalectomy with the transumbilical approach and agreed to participate in this study were included. Patients were randomly divided into two groups the 2-octyl cyanoacrylate group (Glue group) or the non-use group (non-Glue group). A single surgeon (AM) carried out all procedures between 2014 and 2017. Results There were no significant differences in the clinical background of the Glue and non-Glue groups. The number of patients with moderate or high levels of pain in the resting/moving period on postoperative days 1, 2 and 3 was 6/10 (46%/77%), 6/9 (46%/69%) and 3/5 (23%/38%) in the non-Glue group, and 5/7 (38%/54%), 2/7 (15%/54%) and 1/3 (8%/23%) in the Glue group. These differences were not significant. In the subgroup analysis of patients aged less then 50 years, the numbers were 4/6 (57%/86%), 5/7 (71%/100%) and 3/5 (43%/71%) in the non-Glue group, and 3/4 (33%/44%), 1/4 (11%/44%) and 0/1 (0%/11%) in the Glue group in the resting/moving period. On postoperative days 2 and 3, these differences were significant (P = 0.035 and 0.037 in the resting period, and P = 0.017 and 0.013 in the moving period). Conclusions 2-octyl cyanoacrylate can be used safely for laparoscopic adrenalectomy with the transumbilical approach, and might be useful for reducing postoperative pain in patients aged less then 50 years.Background To introduce and evaluate an updated surgical technique for the treatment of tendinous mallet finger deformity. Methods From April 2017 to September 2018, 13 cases of tendinous mallet finger deformity were treated. All patients had zone I extensor tendon rupture, with no residual tendon at the insertion for suture, and no avulsion fracture in the distal phalanx. Extensor tendon insertion reconstruction was realized by suturing the transferred portion of the flexor digitorum profundus tendon with the proximal end of the extensor tendon via a constructed bone tunnel. The treatment efficacy of the enrolled patients was evaluated by using Dargan evaluation criteria post-operatively. Results All patients were followed up with an average duration of 10.6 months. At the last follow-up, 12 patients showed excellent function recovery and one case had unsatisfactory outcome according to the Dargan evaluation criteria. Conclusion Satisfactory therapeutic outcome for the treatment of tendinous mallet finger deformity can be achieved by reconstructing extensor tendon insertion using a part of the flexor digitorum profundus tendon, implying that the proposed treatment method is worthy of clinical application.Microgel nanoreactors maintain the stability of metallic nanoparticles and regulate their catalytic activity. However, limited by the synthetic method, the recycling ability and long-lasting stability of microgel nanoreactors are challenged. Herein, a brand-new nanoparticle carrier, ultralow crosslinked poly(N-isopropylacrylamide-b-methacrylic acid) (P(NIPAm-b-MAA)) microgel, is synthesized based on the reversible addition-fragmentation chain transfer polymerization method and the self-crosslinking mechanism of PNIPAm. This carrier enables the easy preparation, low cost, long-lasting stability, and high catalytic efficiency of nanoreactors. find more As far as it is known, the catalytic reduction rates of several dye models used in this work are the highest ones in similar systems. In addition, the presence of the MAA block leads to the agglomeration and dispersion of the microgels under different pH conditions, thus realizing rapid recycling of the nanoreactors. This novel carrier has great potential for a wide range of applications in catalysis.