Sherwoodpollock2173

Neonatal mortality is high in laboratory mouse breeding, and causes are poorly understood. Post-mortem analysis of pups is an often overlooked source of information and insight. learn more We present a necropsy protocol for neonatal mice designed for easy practical application by animal technicians.

This thematic synthesis is aimed at providing an overview of qualitative studies on parenting experiences during cancer and focuses on the investigation of the challenges parents face and the strategies they use to adapt to a new situation.

A search of five electronic databases was conducted, specifying publication dates between 1993 and 2020. Qualitative studies, which focused on parenting experiences of cancer patients with minor children from an ill parent perspective, were included in the review. Thematic synthesis was undertaken to examine the included studies by referring to a theoretical model of family resilience by Froma Walsh.

12,345 articles were discovered and, after assessment for eligibility, 27 studies were included in the review. The thematic synthesis involved line by line coding of the findings of the primary studies and the development of descriptive and analytical themes.

This review showed that parenting is a process that requires restructuring in the face of cancer. After cancer diagnosis, requirements connected to the illness and its treatments are imposed on previous family life duties.

This review showed that parenting is a process that requires restructuring in the face of cancer. After cancer diagnosis, requirements connected to the illness and its treatments are imposed on previous family life duties.Aim The aim of this cross-sectional study was to determine which functional tests are able to predict falls in nursing home residents (NHR) and community-dwelling (CDW) older adults grouped by age. Methods Two hundred and fifty-two older adults were assessed in the following tests, Mini-Mental State Examination, anthropometric characteristics, fall history and functional tests. The participants were assigned to one of the following groups Young Older Adults (YOA; 60-69 years, n = 102; 27.5% NHR), Old Older Adults (OOA; 70-79 years; n = 100; 23.5% NHR) and Very Older Adults (VOA, ≥80 years; n = 50; 52% NHR). Results The five times sit-to-stand showed 1.41 odds to experience a fall in the NHR of the VOA. In the CDW, the handgrip strength score decreased the odds to fall occurrence (0.92 odds) in the YOA, while the low score in timed up and go test of the OOA showed 1.21 odds to experience a fall. link2 Conclusions Therefore, the five times sit-to-stand test can predict falls in NHR of VOA groups, while handgrip strength and timed up and go tests can predict falls in CDW of YOA and OOA groups, respectively.

The Over-The-Scope Clip (OTSC) can effectively treat refractory gastrointestinal diseases. However, most reports have focused on short-term effectiveness. We examined clinical outcomes of the deployed clips and long-term characteristics.

Of 47 patients with OTSC treatment, 35 with follow-up periods of ≥3 months were retrospectively examined. The indications were 11 bleedings, 17 perforations, and seven fistulas. The observation period was defined as medium-term (3 to <12 months) or long-term (≥12 months). The primary outcome was the clinical success rate without disease recurrence. The secondary outcomes were the complication rate, survival duration, and clip retention rate.

The medium- and long-term clinical success rates were 100% during the observation period (median, 44 months; range, 3-78 months). The complication rate was 2.9% (

 = 1). The median survival time was 1,634 days for bleeding, 1,757 days for perforation, and 444 days for fistulas. The overall clip retention rates were 56.4%, 38.1%, 30.9%, and 25.9% after one, six, and 12 months and at the final follow-up, respectively. The average clip retention duration was 244 days in bleeding, 656 days in perforations, and 188 days in fistulas.

Regardless of clip detachment, the OTSC can be effective in long-term.

Regardless of clip detachment, the OTSC can be effective in long-term.This systematic review with meta-analysis (SRMA) was conducted to assess the effects of high-intensity interval training (HIIT) programmes on men soccer players' aerobic fitness (maximal oxygen uptake and aerobic performance), repeated sprint ability (RSA), vertical jump height (VJH), and linear sprinting time (ST). An electronic search yielded 1,714 articles, 33 of which were included in the present study. Meta-analyses revealed significant benefits of HIIT compared to controls in maximal oxygen uptake (p = 0.018), AP (p = 0.041), and RSA (p = 0.049). No significant effects were found in terms of ST (p = 0.080). The meta-analyses of non-controlled studies revealed significant improvements after HIIT in maximal oxygen uptake (p = 0.001), AP (p = 0.007), RSA (p = 0.001), and ST (p less then 0.001). However, no significant improvements in VHJ were found (p = 0.063). Furthermore, no significant differences were found in sub-group analysis (comparisons between HIIT types). In conclusion, HIIT is effective for improving maximal oxygen uptake, AP, and RSA regardless of the HIIT type. For VHJ and ST outcomes, it seems reasonable to complement the HIIT since it might not be enough to achieve significant changes.Since the outbreak of the SARS epidemic in 2003, the Chinese government has increased inputs to bolster the health care system. However, the COVID-19 pandemic has exposed the geographic maldistribution of health resources in China. We examine the spatial and temporal variation of the SARS epidemic using a difference-in-differences strategy. Our empirical results show that, compared with cities without SARS case reports, exogenous health shocks significantly increased the affected cities' medical resources supply. We provide multiple robustness tests to examine the validity of the main findings. Further study shows that the mechanism is because the SARS event increased the financial autonomy of the epidemic-affected cities, thus providing an incentive for local governments to increase health resources. Meanwhile, health shocks have little influence on the regions with only imported cases than the infected area. These findings provide a possible explanation for the inequality in the distribution of health resources.The increasing number of older adults in society is becoming a major social focus. The article discusses demographic changes in Polish society in the context of the role played by the educational institution known as the University of the Third Age. Although implementing the idea of lifelong learning, such institutions constitute an important space allowing participants to experience life more fully by improving its quality. link3 The information in this article can be used by other countries to organize education for older adults.The present study examined the metabolic responses to an acute bout of football and the overall and moderating role of physical fitness on these responses, in adolescents. Thirty-six adolescents (16 girls, 20 boys; 12.6±0.5 y) completed two trials (60-min football and 60-min seated rest) separated by 7-d. Capillary blood samples were taken at baseline (60-min prior to exercise/rest), immediately, 30- and 60-min post-exercise and 30-, 60- and 120-min following a standardised lunch (1.5-, 2- and 3-h post-exercise), for the determination of blood glucose and plasma insulin concentrations. The median split of distance covered on the multi-stage fitness test was used to define high- and low-fit groups. Overall plasma insulin tAUC following lunch was lower in high-fit participants compared to low-fit (high-fit 3784.2±1653.1 pmol·L-1x120min, low-fit 6457.3±3290.7 pmol·L-1x120min; p0.05). These data emphasise the importance of physical fitness for metabolic health in adolescents, as well as the utility of football as a popular form of games-based activity for improving glucose regulation.The term 'amphetamine' refers to a class of synthetic drugs which includes methamphetamine. The latter is a globally popular drug of abuse which induces euphoria, affecting cognitive/psychomotor performance and sleep. It also provokes risk taking and violent behaviour. The central effects of methamphetamine are due to the overproduction of neurotransmitters, resulting in high levels of dopamine. In recent years, there have been significant increases in cases of methamphetamine abuse in North and South America, Australia and Asia due to its ready availability and low cost. The following review examines changing trends in methamphetamine use and problems that arise diagnostically in medico-legal cases in determining the significance of post-mortem blood levels, the relationship of these to ante-mortem levels, the possible effects on physical and psychological behaviours and the possible contribution of the drug to a lethal episode.The chemical modifications of lignin-based superplasticizers have attracted extensive attentions during recent years. The comprehending of the structure-activity relationship of lignin-based superplasticizer is important to promote the modification and application research of lignin resources. However, lignin features complex and variable molecular structure, which is not conducive to study on structure-activity relationship of lignin-based superplasticizer as well as development and application of new lignin-based superplasticizer. However, the related research work can be simplified by selecting small molecular compound with appropriate molecular structure as the lignin model compound. This article intends to study the structure-activity relationship of lignin-based superplasticizer by using dihydroeugenol as the lignin model compound. Through the substitution of lignin by dihydroeugenol during the synthesis process, a model compound lignin-based superplasticizer (DAFS) was synthesized. The adsorption and dispersion properties of this superplasticizer and reference sample (LAFS) were investigated by fluidity test, Zeta-potential measurement, Total organic carbon analysis and others. The results suggest that the adsorption behavior of both DAFS and LAFS conformed to the Langmuir isotherms and Pseudo-second order kinetic. In cement paste, added with 1 g/L of LAFS and DAFS, Zeta potential were reduced from +3.5 to -15.2 mV and -18.7 mV, respectively. The substitution of lignin by dihydroeugenol has no significantly influence on the dispersive property, but differences on rheological properties which need to be optimized in the future. All the tests confirmed that dihydroeugenol is suitable to replace lignin on exploring the structure-activity relationship of lignin-based superplasticizer. This research work provides new insight on model study of lignin-based superplasticizer.Drosophila melanogaster has proven to be a powerful genetic model to study human disease. Approximately 75% of human disease-associated genes have homologs in the fruit fly and regulatory pathways are highly conserved in Drosophila compared to humans. Drosophila is an established model organism for the study of genetics and developmental biology related to human disease and has also made a great contribution to epigenetic research. Many key factors that regulate chromatin condensation through effects on histone post-translational modifications were first discovered in genetic screens in Drosophila. Recently, the importance of chromatin regulators in cancer progression has been uncovered, leading to a rapid expansion in the knowledge on how perturbations of chromatin can result in the pathogenesis of human cancer. In this review, we provide examples of how Drosophila melanogaster has contributed to better understanding the detrimental effects of mutant forms of histones, called 'oncohistones', that are found in different human tumours.