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In contrast, Waorani and Cofán households have maintained small footprints, while Secoya households largely abandoned cattle ranching. Taken together, the results emphasize ethnic heterogeneity in indigenous land use change, a pattern which is only visible through the use of a longitudinal, large-sample, field-based design.The Data-driven Optimization of bi-level Mixed-Integer NOnlinear problems (DOMINO) framework is presented for addressing the optimization of bi-level mixed-integer nonlinear programming problems. In this framework, bi-level optimization problems are approximated as single-level optimization problems by collecting samples of the upper-level objective and solving the lower-level problem to global optimality at those sampling points. This process is done through the integration of the DOMINO framework with a grey-box optimization solver to perform design of experiments on the upper-level objective, and to consecutively approximate and optimize bi-level mixed-integer nonlinear programming problems that are challenging to solve using exact methods. The performance of DOMINO is assessed through solving numerous bi-level benchmark problems, a land allocation problem in Food-Energy-Water Nexus, and through employing different data-driven optimization methodologies, including both local and global methods. Although this data-driven approach cannot provide a theoretical guarantee to global optimality, we present an algorithmic advancement that can guarantee feasibility to large-scale bi-level optimization problems when the lower-level problem is solved to global optimality at convergence.[Purpose] The efficacy of exercise therapy in temporomandibular disorders has been recognized. Here, we present our experience with exercise therapy. [Participant and Methods] A 25-year-old female with a sudden onset of mouth opening limitation in October 2018 was admitted to our hospital in November 2018. Based on our initial findings, the patient was diagnosed with left disc derangement of the temporomandibular joint without reduction. A definitive diagnosis was established following magnetic resonance imaging in December 2018. Subsequently, range-of-motion exercises for the temporomandibular joint as passive movements and self-traction therapy as active movements were conducted. Magnetic resonance imaging was repeated 4 months after the first treatment. [Results] The temporomandibular joint disc remained in anterior dislocation during mouth opening and closing. The mouth opening joint motion was significantly improved compared to the pre-therapy range. The pain-related visual analog scale score also significantly improved. [Conclusion] The range of motion of the temporomandibular joint was improved by range-of-motion exercises for the temporomandibular joint, and was maintained and managed using self-traction therapy. Improvement of the range of motion was confirmed by magnetic resonance imaging.[Purpose] The aim of this case study is to reconsider the method for preventing orthostatic hypotension in multiple system atrophy. [Participant and Methods] The case was that of a 70-year-old female with multiple system atrophy who experienced frequent falls and orthostatic hypotension. MIRA-1 nmr An orthostatic test was performed, and the effect of cold oral stimulation before standing was compared with no stimulation. Outcome measures were blood pressure, heart rate variability and autonomic variables. [Results] In the control test, blood pressure decreased from 150/72 mmHg in the supine position to 98/58 mmHg in the standing position. Heart rate increased from 71 bpm to 82 bpm, high frequency declined from 16.48 msec2 to 14.07 msec2, and low/high frequency increased from 2.56 to 5.13. Cold stimulation in the standing position induced changes in blood pressure from 168/82 mmHg to 104/72 mmHg, heart rate from 73 bpm to 83 bpm, high frequency from 61.29 msec2 to 24.56 msec2, and low/high frequency from 1.45 to 6.33 msec2. [Conclusion] Standing after cold stimulation affected autonomic variables, but did not affect the heart rate or blood pressure, possibly because of damaged peripheral blood vessels. Further research is required to demonstrate the effect of cold stimulation on orthostatic hypotension.[Purpose] To examine the influence of dorsolateral prefrontal cortex (DLPFC) activation, ankle muscle activities, and coactivation on postural steadiness during dual-tasks. [Participants and Methods] A total of 14 participants (8 males, 6 females) were included. The participants stood straight on the force plate, and performed 3 different tasks 1) a quiet standing (single-task), 2) a repetition of a number (dual-task 1 DT1), and 3) a serial subtraction (dual-task 2 DT2). We divided the participants into 2 groups (S and L group) according to whether their center of pressure paths in the dual-tasks were shorter or longer than those in the single-task. The EMG activity of the gastrocnemius lateralis and tibialis anterior were measured; the oxygenated hemoglobin (oxy-Hb) level in the DLPFC were measured using fNIRS. [Results] The results revealed that oxy-Hb in the left DLPFC increased significantly in all participants during DT2 compared to a single-task. Further, we found that the S group exhibited a higher rate of tibialis anterior activity and ankle muscle coactivation than the L group during DT2. [Conclusion] We concluded that the increase of the DLPFC activation varied with the dual-tasks; moreover, younger individuals modulate their standing posture using different strategies for posture steadiness during posture-calculating task.[Purpose] The main objective of this study was to assess the reliability of the method for testing the attention distribution ability of the elderly using mental arithmetic response time. [Participants and Methods] The participants included in the study were 30 healthy elderly people (over 65 years old), 11 males and 19 females, eight of whom had experienced falls in the past year.In the quiet standing position and the free walking state, we recorded the mental calculation response time of the participants by calculating the two-digit plus or minus one-digit values within 100. The test of the two states were tested in 24 hour intervals. [Results] In the quiet standing and free walking state, the correlation coefficient of the mental arithmetic response time group of the elderly was excellent. The intra-group correlation coefficient of mental arithmetic response time of more than three tests under free walking was greater than 0.9. [Conclusion] We found that the mental arithmetic response time can be used to objectively evaluate the ability of attention distribution in the elderly.

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