Shannoncurrin9192

A vast array of family processes is linked to child mental development, among which (1) low parental acceptance and (2) high family conflict are known as transdiagnostic risk factors for child internalizing and externalizing psychopathology. In contrast to most prior research adopting cross-sectional or lagged designs, the current study applied fine-grained multilevel modeling to elucidate the complex relationships among parental acceptance, family conflict, and child psychopathology, considering the nesting structure of children within families and longitudinal changes within children. We focused on preadolescents from the two-wave Adolescent Brain Cognitive Development Study (N = 4,953; aged 9-12) and accounted for parental psychopathology and sex differences. Our findings suggest that consistent between-family and between-child differences in parental acceptance play a transdiagnostic role for both child internalizing and externalizing psychopathology, whereas family conflict is only significantly associated with externalizing psychopathology. Additionally, short-term within-family and within-child improvements in parental acceptance and family conflict across one year were associated with decreased externalizing, but not internalizing, psychopathology. These findings support the potential importance and feasibility of targeting these family process factors for child externalizing problems outside of an intensive treatment setting. We further discussed how such findings serve as a foundation for future research on family processes and child internalizing problems. The varying results across different grouping levels highlight the importance of decomposing within- from between-family/child effects in future studies on family processes and child psychopathology.The neuropeptide oxytocin (OT) plays a central role in the regulation of affiliative bonds and anxiety. However, the degree to which its levels are synchronized between interaction partners has not yet been assessed. Physiological synchrony assessed using other peripheral measures (e.g., heart rate, etc.) has been tied to positive outcomes for the individual and the dyad. The present study examined OT synchrony in the context of child anxiety and maternal depression by examining mother-child dyads. Mothers and their children with anxiety disorders participated in a behavioral interaction task. Changes in OT levels and mother-child OT synchrony before and after the interaction, as well as their moderation by maternal depression, were assessed. Ninety-eight youth with anxiety disorders (ages 10 to 17) and their mothers underwent psychiatric evaluation, and mothers rated their own depressive symptoms and their children's behavior problems. Salivary OT was assayed from mother and child before and after the task. Behavioral coding showed that interactions were characterized by high behavioral synchrony between mothers and their children, and both individuals displayed higher levels of positive vs. negative affect during the interactions. Mothers and their children also showed decreases in OT levels after the interaction. As hypothesized, OT synchrony increased following the task, but only dyads in which mothers showed high levels of depressive symptoms showed this increase. As hypothesized, lower levels of OT-synchrony were associated with higher levels of child internalizing symptoms. The findings suggest that positive interactions may be beneficial for youth with anxiety disorders with mothers with depression.The Preschool Feelings Checklist (PFC) is a 16-item parent report measure of depressive symptoms in young children. However, data on its reliability and validity are limited. We examined the internal consistency and convergent, discriminant, and predictive validity of the PFC in an unselected community sample of 490 3-year old children. Child psychopathology was assessed using semi-structured diagnostic interviews conducted with a parent at ages 3 and 6 (the Preschool Age Psychiatric Assessment) and with the child and a parent at ages 9, 12, and 15 (the Kiddie Schedule for the Affective Disorders and Schizophrenia, Present and Lifetime Version). The PFC exhibited good internal consistency. It was concurrently associated with depression, as well as a wide range of other psychiatric disorders and functional impairment. Similarly, the PFC at 3 years independently predicted depression and a range of other disorders and global functioning in subsequent assessments later in childhood and in adolescence. Finally, the PFC outperformed the longer Child Behavior Checklist in predicting diagnoses and functioning. Results support the concurrent and predictive validity of the PFC in preschoolers. However, it also exhibited concurrent and predictive associations with a number of other disorders, suggesting that it indexes a broad transdiagnostic liability for psychopathology and impairment.Dysraphic entities like diastematomyelia are not uncommon. LXS-196 PKC inhibitor However, the co-existence of split cord malformation with two pathologically different lesions on the same hemicord is extremely rare. We report a case of a young child who presented with an unusual combination of diastematomyelia, intramedullary lipoma, and dermoid cyst.The COVID-19 pandemic has profoundly influenced public health and contributed to global economic divergences of unprecedented dimensions. Due to the high prevalence and mortality rates, it is then expected that the consequence and public health challenges will last for long periods. The rapid global spread of COVID-19 and lack of enough data regarding the virus pathogenicity multiplies the complexity and forced governments to react quickly against this pandemic. Stem cells represent a small fraction of cells located in different tissues. These cells play a critical role in the regeneration and restoration of injured sites. Because of their specific niche and a limited number of stem cells, the key question is whether there are different anti-viral mechanisms against viral infection notably COVID-19. Here, we aimed to highlight the intrinsic antiviral resistance in different stem cells against viral infection. These data could help us to understand the possible viral infections in different stem cells and the activation of specific molecular mechanisms upon viral entrance.