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Іntroduction of the module «Comorbidity in patients with coronary artery disease current requirements for treatment» into the postgraduate medical education curriculum is considered necessary by 95,5 ± 2,2% of the interviewees. No statistical difference was found betweenthe 1st and the 2ndrespondent groups (р=0,55).

Conclusions The results of the study substantiate the necessity of implementation of continuing medical education of doctors (general practitioners, cardiologists, rheumatologists, neurologists, endocrinologists) on management of patients with multimorbidity and comorbidityusing interactive live workshops and online case studies.

Conclusions The results of the study substantiate the necessity of implementation of continuing medical education of doctors (general practitioners, cardiologists, rheumatologists, neurologists, endocrinologists) on management of patients with multimorbidity and comorbidityusing interactive live workshops and online case studies.

The aim Evaluation of changes in proinflammatory and anti-inflammatory units of the cytokine profile in the mechanisms of development of experimental bacterial-immune periodontitis and elucidation of the effect of flavonol quercetin on its parameters.

Materials and methods Experimental periodontitis was caused by introducing into the tissues of the periodontal complex a mixture of microorganisms diluted with egg protein. In order to enhance the immune response, a complete Freund's adjuvant was injected into the rat's paw at the same time. For correction, intramuscular injections of water-soluble quercetin at a dose of 100 mg / kg body weight were performed for 7 days (7th to 14th day).

Results The use of flavonol quercetin led to a decrease in the serum content of experimental animals with pro-inflammatory cytokines. With regard to anti-inflammatory cytokines, their content in the blood of animals during the development of this simulated inflammatory process changed in the opposite direction. Quercetin a decrease in anti-inflammatory cytokines. Flavonol quercetin reduces the concentration of pro-inflammatory and increases the content of anti-inflammatory cytokines.

The aim of the study was to evaluate retrospectively the mental state of patients, who have had COVID - 19 at the primary level of health care according to medical documentation.

Materials and methods 70 outpatient charts of patients aged from 31 to 80 years who have had laboratory-confirmed SARS CoV-2 and received primary health care, were processed. read more Conducted assessment for the presence and determination of the severity of depression based on the scale of PHQ 9; screening for post-traumatic stress disorder (PTSD) (Breslau et al., 1999).

Results and conclusions patients, who have had SARS CoV-2, the moderate severity of depressive syndrome prevailed. The risk of forming of PTSD is most presented in patients who have had severe SARS CoV-2, who had inpatient treatment and combined with low quality of life (QOL) at outpatient treatment as well. The increase of anxiety was found in individuals after outpatient and inpatient treatment, and it was accompanied with low QOL. Patients with complaints about cogn in 100%. Sleep disturbances were detected in 90.3% of patients with complicated course of SARS CoV-2 during inpatient treatment with low QOL. Tachycardia was detected in 61.7% of patients in group 1 and in 52.2% in group 2, that could be a symptom of increased anxiety and PTSD, but it requires differential diagnosis with cardiac pathology.

The aim To determine the diagnostic value of serum levels of ST2 in patients with the acute coronary syndrome (ACS) and its correlation with NT-proBNP levels.

Materials and methods NT-proBNP and ST2 concentration in serum of patients was measured on admission to the hospital and on the 10th day of the treatment using NT-proBNP ELISA (Biomedica, Slovakia) and Presage ST2 assay (Critical Diagnostics, USA), respectively.

Results Statistically significant direct correlations (p<0.05). The simultaneous increase of ST2 and NT-proBNP serum levels above their threshold in patients with ACSelST (sensitivity - 92.5 %, specificity - 74.2 %, AUC - 0.893, р<0.05) indicated a significant risk of cardiovascular (CV) complications of acute myocardial infarction (AMI) during the inpatient period, e.g. acute heart failure, acute LV aneurysm, recurrent AMI, as well as rhythm and conductivity disturbances.

Conclusions The data suggest that both ST2 and NT-proBNP may prove useful in predicting unfavorable prognosis during the inpatient care of AMI, as the simultaneous increase of these biomarkers above their threshold values indicates a significant risk of CV complications.

Conclusions The data suggest that both ST2 and NT-proBNP may prove useful in predicting unfavorable prognosis during the inpatient care of AMI, as the simultaneous increase of these biomarkers above their threshold values indicates a significant risk of CV complications.

The aim To obtain the first estimates the incidence of surgical site infection in patients undergoing neurosurgical procedures and antimicrobial resistance of responsible pathogens, and determine their impact on inpatient mortality in Ukraine.

Materials and methods We performed a multicenter prospective study was patient-based data of SSIs were according to CDC/NHSN methodology. This study included patients undergoing a neurosurgical procedure in 11 tertiary care hospitals from different regions of Ukraine from January 1st, 2018 to December 31st, 2020.

Results A total of 1697 neurosurgical procedures associated with a 90-day SSI were identified (19.4% of 8741 procedures). Of these, 69.5% SSI were identified after craniotomy and 30.5% after ventricular shunt. The Meningitis or ventriculitis (20.9%) were found to be the most common underlying condition among these patients followed by Intracranial infection (18.7%), and Osteomyelitis (14.6%) congenital malformation. Over a 90-day surveillance period, 387 urgery patients.

The aim To determine the significance of multidisciplinary approach to management of pediatric patients with skin symptoms of food allergy.

Materials and methods The study included of 36 patients aged 4 to 6 years with skin manifestations of food allergy, of which 18 were randomly included in the study group and had a multidisciplinary approach to treatment and the other 18 patients constituted a comparison group and used a standard therapy regimen. Observation of children was carried out for 3 months.

Results Assessment of the severity of the cutaneous form of food allergy by SCORAD score showed the average degree of disease activity in the groups of the study at the beginning of treatment and significantly better dynamics in patients of the study group (p=0.0055). In 88.9% (n=16) of patients in the study group and 61.1% (n=11) of the control group, the process became mild.

Conclusions The application of a multidisciplinary approach allows the integrated implementation of medical, nutritional, and psychological aspects, which significantly increases the effectiveness of treatment and improves the quality of life of patients and their parents.

Conclusions The application of a multidisciplinary approach allows the integrated implementation of medical, nutritional, and psychological aspects, which significantly increases the effectiveness of treatment and improves the quality of life of patients and their parents.

The aim To assess the functional state of gonads in female adolescents with a history of intact uterine appendages torsion (IUAT).

Materials and methods A total of 55 adolescent girls aged from 13 to 17 years were examined. 35 patients with a history of IUAT were divided into two groups group 1 consisted of 21 patients with organ-preserving surgical treatment (detorsion) and group 2 of 14 patients with radical surgical treatment of IUAT. 20 healthy girls formed the control group. Assessment of the ovarian reserve was performed by the determination of serum anti-Müllerian hormone (AMH) level. Ultrasound scan was used to evaluate ovaries volume, number and diameter of antral follicles.

Results The AMH level in control group (2.4 ± 0.29 ng/ml) has no statistically significantly differences compared with group 1 (2.2 ± 0.35 ng/ml, p = 0.12) and differed significantly compared with group 2 (0.96 ± 0.11 ng/ml, p < 0.05). No statistically significant differences in ovary volume were found between group 1 and control group (6.02 ± 0.21 cm3 and 6.14 ± 0.17 cm3, respectively, p = 0.125). The number and diameter of antral follicles in group 1 didn`t significantly differ from the control group (3.85 ± 0.35 and 4.00 ± 0.25, p = 0.116, 3.57 ± 0.42 mm and 3.70 ± 0.31 mm, p = 0.128, respectively).

Conclusions The method of choice for IUAT treatment taking into account upcoming motherhood is laparoscopy with detorsion. Dynamic ultrasound results and determination of AMH level indicate the organ-preserving tactics for surgical treatment of IUAT.

Conclusions The method of choice for IUAT treatment taking into account upcoming motherhood is laparoscopy with detorsion. Dynamic ultrasound results and determination of AMH level indicate the organ-preserving tactics for surgical treatment of IUAT.

The aim To study the clinical and laboratory characteristics of measles, as well as to compare the course of this disease in vaccinated and unvaccinated children in the Poltava region (Ukraine).

Materials and methods 104 inpatients with measles were examined vaccinated (n=27) and unvaccinated (n=77). The patient examination program included assessment of complaints and anamnestic data obtained by questioning (during admission to hospital treatment, during treatment and after discharge) and detailed analysis of medical records (Form № 003/у), physical examination, general clinical study of peripheral blood. Statistical processing of the study results was carried out by methods of variation statistics using the program «SPSS 17.0».

Results The clinical and laboratory picture of measles in the examined patients is typical for this disease. Measles vaccinated children are significantly less likely to have fever (р=0.001) and Koplik's spots (χ2=3.80, р=0.051), the duration of fever (р=0.001), cough (р=0.000), and the length of hospital stay (р=0.000), as well as 3.0 times less often leukopenia is detected (р=0.043) and 2.0 times less often - acceleration of ESR (р=0.023).

Conclusions The obtained data raise the question of expanding the explanatory work on the importance of a full course of preventive vaccination among children, as well as increasing the volume of public procurement of necessary drugs to increase public access to free vaccination.

Conclusions The obtained data raise the question of expanding the explanatory work on the importance of a full course of preventive vaccination among children, as well as increasing the volume of public procurement of necessary drugs to increase public access to free vaccination.

The aim The aim of the study was to determine the level of bacterial contamination of mobile phones and watches of dentists.

Materials and methods The study was conducted at the University Dental Clinic and Microbiology Laboratory at the Department of Genetics, Plant Physiology and Microbiology of Uzhhorod National University. Swabs from the investigated surfaces of 30 mobile phones and 30 watches were collected using disposable sterile cotton swabs moistened with sterile saline. The clinical isolates were isolated with the use of differentially diagnostic nutrient media.

Results Studies have shown that cell phones are contaminated with pathogenic microorganisms to a much greater extent than watches. 1518 CFU were isolated from mobile phones, while 375 CFU from watches. The dominant representatives of the microflora of the studied objects were gram positive bacteria of the genus Staphylococcus. Comparative characteristics of the species composition of bacteria of the genus Staphylococcus isolated from mobile phones and watches showed that the dominant species isolated was S.