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000). The high expression rate of Malat-1 was correlated with age, tumor staging, degree of differentiation and lymph node metastasis (P=0.018, 0.000, 0.000, and 0.000). The median survival time and the 1-year, 3-year and 5-year survival rates of patients with high Malat-1 expression were lower than those with low expression of Malat-1 (P=0.006, 0.011, 0.000 and 0.002). High expression of Malat-1 is an independent risk factor for poor overall survival (OS) in bladder cancer patients.

Overexpression of Malat-1 in bladder carcinoma tissues is associated with malignant biological characteristics and poor prognosis of patients.

Overexpression of Malat-1 in bladder carcinoma tissues is associated with malignant biological characteristics and poor prognosis of patients.

To study the nursing efficacy of health management based on family and organization on elderly diabetic patients.

We collected clinical data from 126 elderly diabetic patients treated in our hospital from March 2018 to March 2019. The patients were divided into a control group and a study group by random number table method, with 63 cases in each group. The control group adopted routine nursing intervention, while the study group adopted the family and organization health education model. We compared the nursing intervention effects of the two groups and evaluated psychological states, blood glucose and quality of life.

After nursing intervention, the study group's nursing efficacy and blood glucose volatility indexes were significantly better than those of the control group (P<0.05). There were significant differences between the SAS and SDS scores of the two groups before and after treatment (P<0.05). Both groups' life quality scores were significantly higher after nursing intervention (P<0.05), and the study group's score was much higher (P<0.05). After nursing intervention, the study group's blood glucose level was significantly lower than that of the control group (P<0.05).

The family and organization health education model is satisfactory in elderly diabetic patients. It can effectively improve patients' medication compliance, reduce the incidence of hypoglycemia, boost patients' quality of life and psychological states, and stabilize blood glucose.

The family and organization health education model is satisfactory in elderly diabetic patients. It can effectively improve patients' medication compliance, reduce the incidence of hypoglycemia, boost patients' quality of life and psychological states, and stabilize blood glucose.

We aimed to explore the multimodal magnetic resonance imaging (MRI) features of brain metastases and high-grade brain gliomas.

Fifty patients with brain metastases and 28 patients with high-grade gliomas treated in the neurosurgery department of our hospital were selected for this study. All patients underwent routine MRI, diffusion tensor imaging, and perfusion-weighted magnetic resonance imaging. The average diffusion coefficient (ADC), fractional anisotropy (FA), regional cerebral blood flow (rCBF), and regional cerebral blood volume (rCBV) in the tumor parenchyma, peritumoral edema area, and the contralateral normal cerebral white matter were compared between the patients with brain metastases and the patients with high-grade brain gliomas.

There were differences in the degree of peritumoral edema between the two groups of patients (P = 0.017). Compared with the patients with high-grade gliomas, the patients with brain metastases had lower FA values in the tumor parenchyma area, higher ADC values in the peritumoral edema area, and lower rCBV and rCBF values in the peritumoral edema area (all P<0.001).

The measurement of the ADC, rCBV, and rCBF values in the peritumoral edema area and the FA values in the tumor parenchyma area using multimodal MRI can have essential clinical value in the differentiation between brain metastases and high-grade gliomas.

The measurement of the ADC, rCBV, and rCBF values in the peritumoral edema area and the FA values in the tumor parenchyma area using multimodal MRI can have essential clinical value in the differentiation between brain metastases and high-grade gliomas.

This study aimed to investigate the therapeutic effects of two different blood purification treatments combined with immunosuppressants on patients with lupus nephritis (LN) and their effects affecting granulocyte-macrophage colony-stimulating factor (GM-CSF) and CXC chemokine ligand-16 (CXCL16) levels.

Ninety patients with LN admitted to our hospital were enrolled and randomly assigned into groups A and B. Group A was treated with continuous veno-venous hemofiltration (CVVH) combined with conventional medical treatment (CMT, n = 40, including 23 females and 17 males), whereas group B was treated with intermittent hemodialysis combined with conventional medical treatment (n = 50, including 35 females and 15 males). Both groups received prednisone and cyclophosphamide.

GM-CSF and CXCL16 levels in the two groups were significantly reduced after treatment (

< 0.05); and GM-CSF level in group A was significantly lower than that in group B (

< 0.05, -1.261 to -0.8395), and CXCL16 level in group A was significantly lower than that in group B (

< 0.05, -0.5745 to -0.4355). There was no significant difference in general data between the two groups (

> 0.05). After treatment, the SLEDAI scores were significantly decreased in both groups, and were significantly lower in group A than in group B (

< 0.05, -1.816 to -0.1241).

CVVH combined with conventional medical treatment is more effective than intermittent hemodialysis combined with conventional medical treatment, and is easier to remove GM-CSF and CXCL16.

CVVH combined with conventional medical treatment is more effective than intermittent hemodialysis combined with conventional medical treatment, and is easier to remove GM-CSF and CXCL16.

To evaluate the diagnostic value of ultrasound detection of the fetal middle cerebral artery, umbilical artery blood flow and fetal movement reduction in fetal distress.

A total of 30 cases of pregnant women with fetal distress (FIUD) in our hospital were selected as the observation group, and 60 cases of normal pregnant women in the same period were selected as the control group. The fetal umbilical artery, middle cerebral artery resistance index (RI), pulsatility index (PI), the ratio of peak systolic blood flow velocity to end-diastolic blood flow velocity (S/D) and fetal movement reduction were detected. The diagnostic value of the above indicators alone and in combination for fetal distress was observed.

The RI, PI and S/D of umbilical artery in the observation group were higher than those in the control group (P<0.001). The S/D, RI and PI of the middle cerebral artery in the observation group were lower than those in the control group (P<0.01). The number of cases with decreased fetal heart rate in the observation group was significantly higher than that in the control group (P<0.001). The area under the curve (AUC) of umbilical artery S/D, umbilical artery RI, umbilical artery PI, middle cerebral artery S/D, middle cerebral artery PI, middle cerebral artery RI, fetal movement reduction and combined above indexes were 0.788, 0.870, 0.847, 0.852, 0.802, 0.658, 0.750 and 1.000 respectively (all P<0.05). The combined diagnosis has a higher diagnostic value for fetal distress.

Umbilical artery, middle cerebral artery hemodynamics combined with fetal movement has a specific value in diagnosing fetal distress, which is worth of clinical application.

Umbilical artery, middle cerebral artery hemodynamics combined with fetal movement has a specific value in diagnosing fetal distress, which is worth of clinical application.

To investigate the correlation between abnormal glucose metabolism and insulin resistance in patients with liver cirrhosis.

A total of 254 participants were assigned into either the experimental group (EG) (n=123) or the normal group (NG) (n=131). We detected fasting blood glucose (FBG), postprandial blood glucose (PBG), fasting insulin (FINS), postprandial insulin, Hemoglobin A1c (HbA1c) and Insulin sensitivity index (ISI), at the same time, we compared various indexes in different Child-Pugh classification of the experimental group.

The 1-hour PBG and 2-hour PBG in the EG were significantly higher than the NG group (P<0.05), serum insulin level in each period was significantly higher (P<0.05). The insulin sensitivity index (ISI) in the experimental group was statistical significantly lower (-4.21±0.09) VS. (-4.03±0.32), (P=0.031<0.05). Furthermore, the 2-hour PBG and FIN of Child-Pugh grade B patients were significantly higher than that of Child-Pugh grade A patients. The fasting insulin level of patients with cirrhosis of Child-Pugh grade C patients was significantly higher than that of Child-Pugh grade B patients, while FBG, PBG and ISI had no significant difference compared with those of Child-Pugh grade B patients. The higher the level of fasting blood glucose and postprandial blood glucose, the higher the FIN with the aggravation of liver function damage.

Patients with liver cirrhosis had different degrees of insulin resistance. Clinicians can take proactive measures to prevent the occurrence of hepatogenic diabetes mellitus.

Patients with liver cirrhosis had different degrees of insulin resistance. Rhapontigenin inhibitor Clinicians can take proactive measures to prevent the occurrence of hepatogenic diabetes mellitus.

To study the preventive effect of seamless nursing care on pressure ulcer and related complications in elderly inpatients.

This study was performed in 132 elderly patients aged over 65 years. According to the random number table, these patients were allocated to the control group (n=66) and the experimental group (n=66). Patients in the control group received routine care, while those in the experimental group received both routine care and seamless nursing care. The number and grade of pressure ulcer during hospitalization, average length of stay, satisfaction in care, and incidence of complications during hospitalization were compared between the two groups.

The incidence of pressure ulcer in the experimental group, which consisted of grade 1 pressure ulcer (2 cases) was significantly lower than that in the control group (P=0.001), which consisted of grade 1 pressure ulcer (9 cases) and grade 2 pressure ulcer (5 cases). The incidence of complications (wound infection and muscle aches) in the experimental group was significantly lower than that in the control group (P<0.05). Compared with the control group, the average length of stay in the experimental group was decreased (P<0.001). Satisfaction with care in the experimental group was significantly higher than that in the control group (P<0.01).

Seamless nursing care contributes to the reduced number of pressure ulcer, reduced incidence of related complications, and improved satisfaction with care.

Seamless nursing care contributes to the reduced number of pressure ulcer, reduced incidence of related complications, and improved satisfaction with care.

To study the clinical effect of intra-articular injection of antimicrobials in the treatment of prosthetic joint infection (PJI) in patients undergoing artificial hip replacement surgery and its impact on the quality of life.

A retrospective analysis of the clinical data of 116 patients with PJI after artificial hip replacement in our hospital from June 2016 to June 2017 was performed, and they were randomly divided into a study group and a control group, with 58 in each group. The study group was treated with intra-articular injection of antibacterial drugs, and the control group was injected with sodium hyaluronate. The antibacterial effects of the two groups were compared.

The HHS scores of the two groups of patients after treatment increased (P < 0.001), and the increase of the study group was more relevant (P < 0.001). The IL-17 and IL-6 levels noticeably decreased (P < 0.001), and the decrease in the study group was more significant (P < 0.001). The total effective rate after 6 weeks of treatment in the study group was evidently higher compared with the control group (P < 0.