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Furthermore, the reduced susceptibility to itraconazole and voriconazole was overcome by milbemycin oxime.

In conclusion, our study shed more light on the role of the ABC transporter family in T. mentagrophytes, which, if overexpressed, can confer resistance to single azole drugs and even cross-resistance. Finally, milbemycin oxime could be an interesting compound supporting treatment with azole drugs in the case of refractory dermatomycoses.

In conclusion, our study shed more light on the role of the ABC transporter family in T. mentagrophytes, which, if overexpressed, can confer resistance to single azole drugs and even cross-resistance. Finally, milbemycin oxime could be an interesting compound supporting treatment with azole drugs in the case of refractory dermatomycoses.

This is a computational study to develop a rugged self-powered Radioisotope Identification Device (RIID). The principle of operation relies on the High Energy Current (HEC) concept (Zygmanski and Sajo, Med Phys. 43 4-15, 2016) with measurement of fast electron currents between low-Z and high-Z thin-film electrodes separated by nanoporous aerogel films in a multilayer detector structure whose prototypes were previously investigated (Brivio, Albert, Freund, Gagne, Sajo and Zygmanski, Med Phys, 46 4233-4240, 2019), (Brivio, Albert, Gagne, Freund, Sajo and Zygmanski, J Phys D Appl Phys, 53 265303, 2020). Here, we present an optimal detector design that accounts for a wide energy range (keV-MeV) of x-ray-emitting radioisotopes that are of interest to national security and radiation therapy.

We studied numerous multilayer detector geometries with N=1..24 basic detector elements composed of 3 electrodes N x (Al-aerogel-Ta-aerogel-Al). The thicknesses of electrodes and their total number were varied depending on cation and spectral unfolding is robust and it is an important component in practical applications.

A multilayer sensor based on fast electron current was optimized and studied in its abilities as RIID. A balanced design permits the identification of radioisotopes with of a wide range of keV-MeV energies. The device is low cost, rugged, self-powered and can withstand very high dose rates, allowing deployment in difficult conditions, including radiation incidents. The algorithm we developed for radioisotope identification and spectral unfolding is robust and it is an important component in practical applications.

To estimate prenatal depression underdiagnosis prevalence and its associated sociodemographic and obstetric risk factors among a population-based sample of Brazilian pregnant women with depression.

We used data from the Brazilian National Survey (PNS 2013). Of the 22445 women of reproductive age, 800 reported being pregnant. Participants answered the Patient Health Questionnaire-9 (PHQ-9) and a questionnaire with sociodemographic, obstetric, and clinical data. Classification of prenatal depression underdiagnosis was made using the comparison between results obtained from the self-referred question evaluating clinical diagnosis of depression and the results of the PHQ-9. Pregnant women with a PHQ-9 score greater than 8 and with a "No" answer in the clinical question were classified as prenatal depression underdiagnosis. Logistic regression models were performed to obtain crude and adjusted odds ratios (OR) between variables and prenatal depression underdiagnosis.

Prevalence of prenatal depression underdiagnosis was 82.3% (74.8%-87.8%). Pregnant women with non-white skin color and pregnant women with an elementary school degree were more likely to be underdiagnosed with prenatal depression in comparison with women with white skin color (adjusted OR 2.42, 95% confidence interval [CI] 0.99-5.91) and with women with higher education (adjusted OR 4.07, 95% CI 2.05-8.09).

Equitable mental health assistance for pregnant women should considered prenatal depression social risk factors.

Equitable mental health assistance for pregnant women should considered prenatal depression social risk factors.Oleogels and oleogelation routes have been extensively studied in the past decade; however, the industry has not yet implemented this technique due to price, availability, and clean label. The objective of this study was to evaluate the synergism of binary oleogels structured by monoglycerides (MG) and high melting point triacylglycerols (HF) with and without high-intensity ultrasound (HIU) according to their physical properties. selleck kinase inhibitor MGHF (06, 15, 24, 33, 42, 51, and 60) oleogels were produced by mixing at 70 °C with a stirring of 350 rpm for 5 min, followed by a cooling and storage at 20 °C for 24 hr. A 20-kHz HIU was applied for 10s, 30s, or 10s using three pulses (10sON/10sOFF) during the cooling step via a macro tip (12.7 mm) and 50% amplitude (56 W) in the presence of few -crystals. Samples were evaluated according to their hardness, oil-binding capacity (OBC), microstructure, melting behavior, viscoelasticity, and flow behavior. The best physical properties were found in the MG6HF0 oleogel, with a hardness eogels without increasing the amount of oleogelators, giving a future alternative to clean label and sensory claims of oleogels applications.Echium seed oil is an alternative source of omega 3 fatty acids but it is highly susceptible to oxidation. A combination of three natural strategies was proposed in this study aiming to improve the oxidative stability of echium oil obtained by pressing (PO) or solvent extraction (PSO), kept in the storage condition for 180 days or during the consumption for 30 days. Our results showed that the reduction of temperature was sufficient to keep the oil stable during storage for both samples. During the consumption time, the best stability was achieved by adding a mixture of antioxidants, composed of sinapic (500 ppm), ascorbic (250 ppm), and citric (150 ppm) acids, and/or 20% of high oleic sunflower oil. The combined strategies promoted a 34 to 80% reduction of peroxide value and 0 to 85% reduction of malondialdehyde concentrations in the samples, showing to be a feasible and natural alternative to improve the oxidative stability of echium oil. PRACTICAL APPLICATION Our study successfully applied an optimized combination of simple and low-cost strategies to enhance the chemical stability of echium seed oil.