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The results of this study have informed the need for future product design and highlighted PAE is an effective mode for continued rehabilitation in third-sector services.

These findings indicate that membership of a stroke venue alongside engagement with PAE facilitated transition from early stroke rehabilitation into longer term recovery. The results of this study have informed the need for future product design and highlighted PAE is an effective mode for continued rehabilitation in third-sector services.

Unilateral ligation of the pulmonary artery may induce lung injury through multiple mechanisms, which might be dampened by inhaled CO2.

To characterize bilateral lung injury due to unilateral ligation of pulmonary artery in healthy swine undergoing controlled mechanical ventilation and its prevention by 5% CO2 inhalation. To investigate relevant pathophysiological mechanisms.

Sixteen healthy pigs were allocated to surgical ligation of the left pulmonary artery (Ligation group), 7 to surgical ligation of the left pulmonary artery and inhalation of 5% CO2 (Ligation + FiCO2 5%), and 6 to no intervention (No Ligation). Then, all animals received mechanical ventilation with tidal volume (Vt) 10 ml/Kg, positive end-expiratory pressure 5 cmH2O, respiratory rate 25 bpm and FiO2 50% (±FiCO2 5%) for 48 hours or until development of severe lung injury.

Histological, physiological and quantitative CT-scan data were compared between groups to characterize lung injury. Electrical impedance tomography and immunohistft pulmonary artery ligation. Inhalation of 5% CO2 prevents injury, likely through decreased stress to the right lung and anti-inflammatory effects. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http//creativecommons.org/licenses/by-nc-nd/4.0/).Given the higher suicide rates among the adult population in the northernmost part of Norway and some unfavourable psychosocial outcomes associated with the Laestadian revival movement in this region, it is reasonable to investigate the relationship between religiosity/spirituality and suicidal behaviour in this context. This study used cross-sectional data from the population-based SAMINOR 2 questionnaire survey (2012; n = 11,222; 66% non-Sámi; 22% Laestadian-affiliated; 27% response rate) in mixed Sámi-Norwegian areas of Mid and North Norway. We analysed the associations between religious/spiritual factors and lifetime suicidal ideation and attempts, age at the first attempt, motives, and number of attempts. Multivariable-adjusted regression models considering sociodemographics, Sámi background and self-ascription, and health-related risk factors were applied. Sámi and Laestadian affiliations were significantly associated with religious self-ascription, regular attendance, and Established Church membership. In a fully adjusted model, Laestadian family background was negatively associated with lifetime suicide attempts (OR = 0.66, 95% CI 0.47-0.93) compared with other family circumstances, whereas regular religious participation was inversely associated with suicide ideation (OR = 0.74, 95% CI 0.61-0.91) compared with non- or rare attendance. The findings suggest that Laestadianism and religious attendance contribute to less suicidal behaviour among adults in Sámi-Norwegian areas.Established methods for postural ergonomic risk assessment in occupational practice are mostly time-consuming and need to be conducted by experts to guarantee valid and reliable results. Technology could improve postural ergonomic risk assessments with regard to time-efficiency and accuracy. A study was conducted to assess the accuracy of a markerless motion capture system (Microsoft Kinect V2) in comparison to a marker-based motion capture system (Vicon Bonita) while capturing working postures. To evaluate the accuracy of the captured working postures, angles of different body segments were analysed. The results show inaccuracies of the markerless motion capture system capturing axial trunk rotation (mean angular deviation of 14.04°). In addition, for combined working postures of axial trunk rotation and arm anteversion, issues with self-occlusion were observed. The findings indicate that, detected inaccuracies for axial trunk rotation are likely to lead to an underestimation of potential health risks when conducting an ergonomic risk assessment.Social support is associated prospectively with cognitive decline and dementia among the elderly; however, little is known about the impact of social support on healthy neurological aging. The current study investigates whether perceived social support has an influence on neurological health among a large sample of healthy postmenopausal women. Social support and neuropsychological outcomes were measured annually for six years through the Women's Health Initiative Study of Cognitive Aging. In postmenopausal women, higher perceived social support was associated with significantly better overall neuropsychological functioning at baseline, especially in the domains of short-delay figural memory, short-delay verbal memory, and semantic fluency. No significant associations were found between social support and longitudinal changes in neuropsychological function over a median follow-up period of six years. Additionally, there was no significant relationship between social support and regional brain volumes. These findings suggest that social support is related to performance in a subset of neuropsychological domains and contributes to the existing literature that points to the importance of social support as a modifiable lifestyle factor that has the potential to help protect against the decline of cognitive aging, specifically among older adult women.

To compare endovascular and drug therapies for efficacy and safety in patients with a progressive stroke caused by intracranial large vascular occlusion exceeding the time window of 24hours.

A total of 58 patients with progressive stroke caused by large intracranial vascular occlusion exceeding the time window of 24hours treated in the stroke center of our hospital for three years were retrospectively analyzed . According to the applied therapy, 58 patients were divided into the endovascular (n=19) and drug (n=39) therapy groups. Then, modified Rankin scale (mRS) scores, symptomatic intracranial hemorrhage rates, mortality rates and adverse events were assessed in both groups within 90days.

The 90-day good prognosis rate was significantly higher in the endovascular therapy group compared with the drug group (68.4% VS 38.5%, odds ratio [OR]=0.29; 95% confidence interval [CI], 0.09-0.92;

=0.032). The 90-day NIHSS scores were lower in the endovascular therapy group compared with the drug group (3.3±2.6 VS 5.2±3.0, OR=-1.89; 95%CI, -3.50 to -0.27;

=0.023). Meanwhile, the proportion of patients with a Barthel index of 90-100 was significantly higher in the endovascular therapy group compared with the drug group (53.0% VS 25.6%, OR=0.31; 95%CI, 0.10-0.98;

=0.042). Finally, both groups showed similar rates of adverse events.

In patients with progressive stroke caused by large intracranial vascular occlusion exceeding 24hours, endovascular therapy probably results in improved efficacy at 90days compared with drug therapy, without increasing the rates of adverse effects.

In patients with progressive stroke caused by large intracranial vascular occlusion exceeding 24 hours, endovascular therapy probably results in improved efficacy at 90 days compared with drug therapy, without increasing the rates of adverse effects.Chronic obstructive pulmonary disease (COPD) patients undergo infectious exacerbations whose frequency identifies a clinically meaningful phenotype. Mouse models have been mostly used to separately study both COPD and the infectious processes, but a reliable model of the COPD frequent exacerbator phenotype is still lacking. Accordingly, we first established a model of single bacterial exacerbation by nontypeable Haemophilus influenzae (NTHi) infection on mice with emphysema-like lesions. We characterized this single exacerbation model combining both noninvasive in vivo imaging and ex vivo techniques, obtaining longitudinal information about bacterial load and the extent of the developing lesions and host responses. Bacterial load disappeared 48 hours post-infection (hpi). D-AP5 cell line However, lung recovery, measured using tests of pulmonary function and the disappearance of lung inflammation as revealed by micro-computed X-ray tomography, was delayed until 3 weeks post-infection (wpi). Then, to emulate the frequent exacerbator phenotype, we performed two recurrent episodes of NTHi infection on the emphysematous murine lung. Consistent with the amplified infectious insult, bacterial load reduction was now observed 96 hpi, and lung function recovery and disappearance of lesions on anatomical lung images did not happen until 12 wpi. Finally, as a proof of principle of the use of the model, we showed that azithromycin successfully cleared the recurrent infection, confirming this macrolide utility to ameliorate infectious exacerbation. In conclusion, we present a mouse model of recurrent bacterial infection of the emphysematous lung, aimed to facilitate investigating the COPD frequent exacerbator phenotype by providing complementary, dynamic information of both infectious and inflammatory processes.Building upon extant research on the reasoned action approach and message sidedness, this study investigates the persuasive effects of one-sided and two-sided social media messages on the attitude about human papillomavirus (HPV) vaccination in the context of misinformation. Results of a controlled experiment (N = 251) indicated that compared to the control, one-sided messages addressing misinformation increased positive attitude about the vaccine as prior misperceptions increased. However, a backfire effect may be looming for individuals with lower prior misperceptions. Within the sidedness conditions, refutational two-sided messages were more effective in increasing cognitive attitude for individuals with lower misperceptions; whereas one-sided messages had a persuasive advantage for individuals with higher misperceptions. Theoretical and practical contributions are discussed.The purpose of this study was to examine former Brazilian high-performance volleyball athletes' perspectives on life skills learning and transfer through their experiences in sport. This qualitative study involved a narrative approach through composite vignettes. The creation of the composite vignettes included the most relevant life events and participants' perspectives through their accounts of the experience transformed in one unique voice. Participants were five former Brazilian high-performance volleyball athletes. Data were collected through rappaport timeline and semi-structured interviews. Findings showed athletes were able to learn and transfer life skills throughout their careers and later in life through an implicit approach to life skills development and transfer. The trials and tribulations of high-performance sport were, in these cases, used as life lessons that transformed into life skills used in athletes' lives beyond sport. Moving forward, more research is needed to understand the high-performance sport's role in life skills transfer and its implication for athletes' development across socio-cultural contexts.