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RESULTS All dogs completed the immunosuppressive protocol. read more No evidence for recrudescence of E. canis, A. platys, or B. vogeli were detected based on clinical signs or results of CBC, PCR, IFA, and flow cytometry for antiplatelet antibodies. E. canis IFA titers were negative in 5/7 dogs at the end of immunosuppressive protocol and were negative 6 months after the protocol in 5/5 dogs available for testing. CONCLUSIONS AND CLINICAL IMPORTANCE Dogs administered with a 4-week course of doxycycline with or without imidocarb failed to show evidence of activation of E. canis infection after administration of a commonly used immune suppressive protocol. © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.Invited for the cover of this issue are the groups of Antonio Frontera at the Universitat de les Illes Balears and Antonio Caballero at the Universidad de Murcia. The image depicts one of the tellurophene based receptors described in this work. Read the full text of the article at 10.1002/chem.201905786. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.It is inherently challenging to recapitulate the precise hierarchical architectures found throughout nature (such as in wood, antler, bone, and silk) using synthetic bottom-up fabrication strategies. However, as a renewable and naturally sourced nanoscale building block, nanocellulose-both cellulose nanocrystals and cellulose nanofibrils-has gained significant research interest within this area. Altogether, the intrinsic shape anisotropy, surface charge/chemistry, and mechanical/rheological properties are some of the critical material properties leading to advanced structure-based functionality within nanocellulose-based bottom-up fabricated materials. Herein, the organization of nanocellulose into biomimetic-aligned, porous, and fibrous materials through a variety of fabrication techniques is presented. Moreover, sophisticated material structuring arising from both the alignment of nanocellulose and via specific process-induced methods is covered. In particular, design rules based on the underlying fundamental properties of nanocellulose are established and discussed as related to their influence on material assembly and resulting structure/function. Finally, key advancements and critical challenges within the field are highlighted, paving the way for the fabrication of truly advanced materials from nanocellulose. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The purpose of this study was to compare the acute effects of time- and effort-matched high-intensity intervals on physiological, endocrine and skeletal muscle molecular variables in elite cyclists. Eight elite cyclists performed short intervals (SI 30-s) and long intervals (LI 5-min) with workrecovery ratio 21, using a randomized crossover design. SI was associated with 14 ± 3% higher mean power output (SI; 421 ± 27 vs LI; 371 ± 22 W), and longer working time above 90% of maximal oxygen uptake (VO2max , 54 ± 76%) and 90% peak heart rate (HRpeak , 153 ± 148%) than LI (all p less then 0.05), despite similar degrees of perceived exertion, blood lactate levels and muscle activation measured using EMG root mean square (EMG rms). In blood, SI was associated with more pronounced increases in testosterone and testosterone-to-sex-hormone-binding-globulin (SHBG) ratios, as well as prolonged cortisol responses (p less then 0.05). In skeletal muscle (m. Vastus lateralis), SI and LI led to similar changes in mRNA abundance for a range of transcripts, with the exception of NHE1 mRNA, which decreased after SI (p less then 0.05). Overall, SI was associated with more pronounced physiological and endocrine responses than LI in elite cyclists, suggesting that such training might lead to superior adaptations in elite cyclists. This article is protected by copyright. All rights reserved.To determine the effect of aromatherapy with rose and lavender on the patient outcomes after open-heart surgery (OHS). In the clinical trial, patients were randomized to four groups. One group received routine care, the placebo group received a cotton swab soaked in water and the other two groups received either a cotton swab containing three drops of rose or lavender essence (0.2 ml). A total of 160 patients were randomized into four groups. Intergroup anxiety was not significantly different; however, the reciprocal time-group effect was significant among the four groups. The extubation time was significant among the four groups which related to rose essence group compared with the control group (p  less then  .001) and placebo group (p = .029). The surgical site pain was significant in the rose essence and lavender groups compared to the control group. Aromatherapy can reduce extubation time, surgical site pain severity, and anxiety in patients undergoing OHS. © 2020 John Wiley & Sons, Ltd.Electrochemical water splitting offers an attractive approach for hydrogen production. However, the lack of high-performance cost-effective electrocatalyst severely hinders its applications. Here, a multinary high-entropy intermetallic (HEI) that possesses an unusual periodically ordered structure containing multiple non-noble elements is reported, which can serve as a highly efficient electrocatalyst for hydrogen evolution. This HEI exhibits excellent activities in alkalinity with an overpotential of 88.2 mV at a current density of 10 mA cm-2 and a Tafel slope of 40.1 mV dec-1 , which are comparable to those of noble catalysts. Theoretical calculations reveal that the chemical complexity and surprising atomic configurations provide a strong synergistic function to alter the electronic structure. Furthermore, the unique L12 -type ordered structure enables a specific site-isolation effect to further stabilize the H2 O/H* adsorption/desorption, which dramatically optimizes the energy barrier of hydrogen evolution. Such an HEI strategy uncovers a new paradigm to develop novel electrocatalyst with superior reaction activities. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.