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Finally, we report a significant interaction between the change in pubertal stage and age in the development of fibre density, for left-lateralised association tracts. Overall, white matter development across ages 9-13 years involves the expansion of major white matter fibre pathways, with key association pathways linked with pubertal stage.Most individuals are willing to forego resources for the benefit of others, but their willingness to do so typically declines as a function of social distance between the donor and recipient, a phenomenon termed social discounting. We recently showed that participants were more altruistic towards strangers when a costly generous choice was framed as preventing a monetary loss to the other rather than granting them a gain. Here, we asked if acute stress would diminish this frame effect on social discounting. To test this hypothesis, 102 male participants engaged in either the Maastricht Acute Stress Task, or a matched, non-stressful control procedure. They subsequently played a two-frame dictator game version of the social discounting paradigm. Whereas both frame conditions were economically equivalent, in the give frame, participants were asked how much money they would share with other persons on variable social distance levels, and in the take frame, they decided on how much money to take away from the others. While non-stressed control participants showed increased generosity toward strangers in the take compared to the give frame, similar to previous findings of our group, stress attenuated this frame effect on social discounting by reducing generosity toward strangers in the take frame. These findings confirm that stress can corrupt prosocial motives and social norm compliance, diminishing prosocial tendencies toward unfamiliar others.

Compound Dan Zhi tablet (DZT) is a commonly used traditional Chinese medicine formula. It has been used for the treatment of ischemic stroke for many years in clinical. However, its pharmacological mechanism is unclear.

The aim of the current study was to understand the protective effects and underlying mechanisms of DZT on ischemic stroke.

Fifteen representative chemical markers in DZT were determined by ultra-performance liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). The protective effect of DZT against ischemic stroke was studied in a rat model of middle cerebral artery occlusion (MCAO), and the mechanism was further explored through a combination of network pharmacology and experimental verification.

Quantitative analysis showed that the contents of phenolic acids, furan sulfonic acids, tanshinones, flavonoids, saponins and phthalides in DZT were calculated as 7.47, 0.788, 0.627, 0.531 and 0.256mg/g, respectively. Phenolic acids were the most protected against cerebral ischemic injury. The inhibition of TXA

level, platelet aggregation and thrombosis formation might involve in the protective mechanism.

DZT protected against cerebral ischemic injury. The inhibition of TXA2 level, platelet aggregation and thrombosis formation might involve in the protective mechanism.

This study was designed to search for ancient parasites in abdominal content and coprolites from Bolivian mummies.

Twelve mummified individuals from the Andean highlands, housed at the National Museum of Archaeology (MUNARQ) in La Paz, Bolivia.

Microscopic analysis of rehydrated samples (coprolites and abdominal content), following Lutz's spontaneous sedimentation technique.

Eggs of Enterobius vermicularis were identified in coprolites from one mummy, and capillariid eggs in the organic abdominal content from another individual.

This is the first evidence of ancient intestinal parasites in Bolivian mummies.

This pioneering study focused on the search of ancient intestinal parasites in human remains of the Bolivian Andes and contributes to greater knowledge of paleoparasitology in South America.

All mummies in the MUNARQ belonged to the Andean Bolivian highlands (post-Tiwanaku era or Late Intermediate Period), although the exact provenance of the material and the associated contexts are not well recorded.

Considering the great number of well-known archaeological sites and other unexplored sites in Bolivia, in addition to large collections in museums, further paleopathological and paleoparasitological molecular studies in mummies and skeletons are called for.

Considering the great number of well-known archaeological sites and other unexplored sites in Bolivia, in addition to large collections in museums, further paleopathological and paleoparasitological molecular studies in mummies and skeletons are called for.People often acquire souvenirs and photographs to facilitate remembering, but possessions and memories can relate to each other in a variety of ways. This review paper presents four different connection types found between meaningful things in our everyday lives and our personal memories. Each connection type either focuses on possessions or memories and the connection between the two is either active or lost. These perspectives will be detailed through examples of studies and design cases from different fields and research areas. More studies have been found focusing on existing connections between possessions and memories, such as in human-computer interaction, design, material culture, psychology and marketing, than those lost, which were specifically focused around ageing, forgetting, heirlooms, identity and hoarding behaviour. Our review of connections between possessions and memories accumulate to suggest the attachment people ascribe to certain possessions is mirrored by the ability of objects to fulfil people's desire to preserve, embody, showcase and recollect certain memories.

Colorectal cancer (CRC) is one of the most frequent and diagnosed diseases. Accumulating evidences showed that mRNAs and noncoding RNAs play important regulatory roles in tumorigenesis. Identification and determining the relationship between them can help diagnosis and treatment of cancer.

Here we analyzed three microarray datasets; GSE110715, GSE32323 and GSE21510, to identify differentially expressed lncRNAs and mRNAs in CRC. The adjusted p-value ≤0.05 was considered statistically significant. Gene set enrichment analysis was carried out using DAVID tool. The miRCancer database was searched to obtain differentially expressed miRNAs in colorectal cancer, and the miRDB database was used to attain the targets of the obtained miRNAs. To predict the lncRNA-miRNA interactions we used DIANA-LncBase v2 and RegRNA 2.0. S1P Receptor inhibitor Finally the lncRNA-miRNA-mRNA-signaling pathway network was constructed using Cytoscape v3.1.

By analyzing the three datasets, a total of 21 mRNAs (15 up- and 6 down-regulated) and 24 lncRNAs (18 up- and 6 down-regulated) were identified as common differentially expressed genes between CRC tumor and marginal tissues.