Ruizstanley0587

Sleep duration, especially short duration, is associated with high blood pressure in adolescents. Such evidence draws attention to implications on cardiovascular health in this age group.

Sleep duration, especially short duration, is associated with high blood pressure in adolescents. Such evidence draws attention to implications on cardiovascular health in this age group.

To evaluate sociodemographic and clinical aspects of children with sickle cell disease (SCD) and their behavioral characteristics.

Interview with parents of patients with SCD from four to ten years old, addressing socioeconomic aspects and other health conditions, and using the Strengths and Difficulties Questionnaire (SDQ). Clinical data were obtained from medical records. Exclusion criteria were the use of hydroxyurea, previous diagnosis of stroke, chronic encephalopathy and/or intellectual disability.

45 patients (19 girls and 26 boys) were assessed. The median age was seven years. Diagnosis of SCD 26 hemoglobinopathy SC; 19 hemoglobinopathy SS. Socioeconomic class D 24.4%; C2 44.4%; C1 28.9%; B2 2.2%. Clinical history acute chest syndrome 40%; transfusions 66.7%; hospitalizations 82.2%. SDQ findings 88.9% clinical impact (emotional subscale 68.9%); total score impact in 48.9%. It was not possible to establish a relation between the severity of the disease and the results of the SDQ. Regarding socioeconomic class among individuals of classes B2 and C1, 21.4% had impact at the total score; in classes C2 and D, this percentage was 61.3%. Regarding the schooling of the head of the family, with Elementary School at least, 39.3% of the children had impacts; for fewer education, this percentage was 64.7%.

Behavioral impacts are highly prevalent in children with SCD. Individuals in socioeconomic classes C2 and D suffered more behavioral impacts than individuals in classes B2 and C1.

Behavioral impacts are highly prevalent in children with SCD. Individuals in socioeconomic classes C2 and D suffered more behavioral impacts than individuals in classes B2 and C1.

To characterize the adherence to the Mediterranean diet (MD) in students from elementary schools in Porto and Maia and analyze its association with sleep hygiene, physical activity, cardiometabolic risk, and school performance.

This is a cross-sectional study with 891 Portuguese students 455 boys (51%) and 436 girls (49%), aged between 9 and 11 years old (mean [M]=9.2, standard deviation [SD]=0.4), with an average weight of 35.9 kg (SD=8.1), average height of 1.4 m (SD=0.1), average body mass index (standardized BMI Z score for the pediatric age group) of 0.76 (SD=1.21); 59.5% of them had normal weight and 15.9% were obese. The students filled a questionnaire on the adherence to the Mediterranean Diet (Mediterranean Diet Quality Index in Children and Adolescents [KIDMED]), participated in a socio-demographic interview, and had their anthropometric data collected after their parents signed the informed consent form.

The results suggest high levels of adherence to the MD (77.6%) both in males and females. Using Pearson's correlation coefficient, we found that the Z score was positively associated to cardiometabolic risk and the starting age of an extracurricular physical activity, and negatively associated to the average hours of sleep on a typical day both in males and females. We also identified a negative relation between KIDMED and the starting age of physical activity.

This study has contributed to the knowledge of adherence to the MD among Portuguese elementary students and correlations with variables associated to a healthier lifestyle (MD, hours of sleep, and physical activity). HS10296 Future studies should focus their attention on other countries and more heterogeneous samples.

This study has contributed to the knowledge of adherence to the MD among Portuguese elementary students and correlations with variables associated to a healthier lifestyle (MD, hours of sleep, and physical activity). Future studies should focus their attention on other countries and more heterogeneous samples.Research on the past use of animals in medicine, particularly in Brazil, is still scarce. This work aimed to perform a dialogical analysis of information retrieved from historical documents composed in the nineteenth century about the therapeutic use of animal species in Benedictine monasteries in Brazil and their contemporary medicinal applications. Cross-referencing of seven written codices from the nineteenth century Benedictine monasteries infirmaries was performed for taxonomic identification and with therapeutic indications. Animal species provided 13 zootherapeutic resources, which were related to 17 therapeutic indications. Insects, birds and mammals concentrated the greatest number of pharmaceutical actions (37%, 32% and 16% of the therapeutic indications). Medicinal animals used in the past are species commonly applied in the European medicine over centuries. This reveals that the practiced medicine in Benedictine monasteries was influenced by medical concepts from Europe. Also, it shows that still today this European medicine is the basis of therapeutic practice. Such research is essential for a better scientific understanding of the history of medicine, focusing on how different cultures have contributed to the actual therapeutic practice. In this way it is possible to trace a history zootherapy in Brazil, demonstrating the persistence of their use over the time.Sildenafil is a potent selective inhibitor of phosphosdiesterase-5 previously used in erectile dysfunction and subsequently approved in 2005 for pulmonary arterial hypertension treatment. Since oral administration of sildenafil shows pharmacokinetic problems with mean absolute bioavailability of 41%, the goal of this work was to develop a novel sildenafil self-emulsifying drug delivery system (SEDDS) for oral absorption improvement and management of dosage. One pharmaceutical solution and four SEDDS containing sildenafil were successfully obtained and SEDDS formed O/W nanoemulsion with droplet size less than 300 nm. The stability studies evidenced that the SEDDS containing 3.3% w/w of sildenafil yielded the best results. The safety of 2-pyrrolidone/isobutanol in oral formulations was assessed in mice and no lethality was achieved in the placebo groups with LD50 of 490 mg/Kg for SEDDS II-3.3, suggesting it as a safe excipient for humans. Therewithal, in silico studies using PBPK models provided the pharmacokinetic profile of sildenafil SEDDS.