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We further pose that the regions where these correlative relationships are violated, i.e., predictability of the polarization dynamics from domain structure is reduced, represent the obvious target for detailed studies, e.g., in the context of automated experiments. This approach provides a workflow to establish the presence of correlation between local spectral responses and local structure and can be universally applied to spectral imaging techniques such as piezoresponse force microscopy (PFM), scanning tunneling microscopy (STM) and spectroscopy, and electron energy loss spectroscopy (EELS) in scanning transmission electron microscopy (STEM).The gold standard treatment for peripheral nerve injuries (PNIs) is the autologous graft, while it is associated with the shortage of donors and results in major complications. In the present study, we engineer a graphene mesh-supported double-network (DN) hydrogel scaffold, loaded with netrin-1. Natural alginate and gelatin-methacryloyl entangled hydrogel that is synthesized via fast exchange of ions and ultraviolet irradiation provide proper mechanical strength and excellent biocompatibility and can also serve as a reservoir for netrin-1. Meanwhile, the graphene mesh can promote the proliferation of Schwann cells and guide their alignments. Zasocitinib manufacturer This approach allows scaffolds to have an acceptable Young's modulus of 725.8 ± 46.52 kPa, matching with peripheral nerves, as well as a satisfactory electrical conductivity of 6.8 ± 0.85 S/m. In addition, netrin-1 plays a dual role in directing axon pathfinding and neuronal migration that optimizes the tube formation ability at a concentration of 100 ng/mL. This netrin-1-loaded graphene mesh tube/DN hydrogel nerve scaffold can significantly promote the regeneration of peripheral nerves and the restoration of denervated muscle, which is even superior to autologous grafts. Our findings may provide an effective therapeutic strategy for PNI patients that can replace the scarce autologous graft.Recombinant spider silk has emerged as a biomaterial that can circumvent problems associated with synthetic and naturally derived polymers, while still fulfilling the potential of the native material. The artificial spider silk protein NT2RepCT can be produced and spun into fibers without the use of harsh chemicals and here we evaluate key properties of NT2RepCT dope at native-like concentrations. We show that NT2RepCT recapitulates not only the overall secondary structure content of a native silk dope but also emulates its viscoelastic rheological properties. We propose that these properties are key to biomimetic spinning and that optimization of rheological properties could facilitate successful spinning of artificial dopes into fibers.The formation of oxide nanorolls decorated with nanotubes during anodic oxidation of amorphous Fe70Cr15B15 alloy in hydrophobic ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate (IL) was revealed. The unusual architecture was observed for the first time on the surface of amorphous alloy. The generation of the novel type of nanostructure by electrochemical oxidation of the amorphous Fe70Cr15B15 alloy occurs only in hydrophobic ionic liquid and in the presence of the natural oxide film at the surface. Anodization of the oxide-free metal surface of the amorphous Fe70Cr15B15 alloy to be achieved by the treatment of the electrode with benzoic acid was found to result in no formation of both nanorolls and nanotubes. Electrochemical behavior of the amorphous Fe70Cr15B15 alloy in ionic liquid was proved to depend strongly on the state of the electrode surface before oxidation. The influence of the state of the surface of amorphous Fe70Cr15B15 alloy leading to the nanostructure formation was studied by means of preliminary partial etching with benzoic acid of various concentrations.Null.Null.Null.Null.Null.Null.Null.Silver-Russell syndrome (SRS) is a rare disorder characterised by prenatal and postnatal growth deficiency, a relatively large head size with triangular face, a prominent forehead, body asymmetry, feeding difficulties, clinodactyly and other features. Abnormalities of chromosome number 7 and 11 have been found in 60% of patients, but the diagnosis of the disease is mainly by ascertaining clinical features. We, herein, report a case of an 11-year boy who presented to Orthodontics Department of Armed Forces Institute of Dentistry (AFID), for treatment of craniofacial and oral problems, which included small-sized jaws and severely crowded teeth. The patient is undergoing serial extraction treatment at the moment, which will be followed by further orthodontic treatment. Key Words Silver-Russell syndrome, Growth deficiency, Triangular face, Body asymmetry.Osteoid osteoma with multiple nidi is a rare condition. The aim of this report is to share a case of an osteoid osteoma with two separate nidi, which underwent radio-frequency ablation (RFA) treatment under CT-guidance for each of the nidi in the same session. A 15-year girl with osteoid osteoma in left tibia was referred to our clinic for percutaneous RFA. She had pain that worsened at nights. The patient was diagnosed as osteoidosteoma, according to radiologic findings and the clinical symptoms. After CT-guided percutaneous RFA of each nidi in the same procedure, pain was relieved in 24 hours. Each of the RFA-treatments was successful in pain control without any complications and no recurrence occurred during eight months of follow-up period. To our knowledge, this case is one of the very few cases with double nidi, which was treated with RFA in one session. RFA is safe in treatment of osteoid osteomas; even two close and separate nidi can safely be treated in the same session. Key Words Osteoid osteoma, Nidi, Treatment, Radiofrequency ablation.Synovial chondromatosis is a rare condition with chondroid metaplasia of the synovial membrane and multinodular proliferation of the synovial membrane of the joints, tendons and bursae without any certain etiology. The disease generally presents in monoarticular form; and the most commonly involved joint is the knee. It commonly occurs in third and fifth decades of life. Synovial chondromatosis of the shoulder in children is extremely rare; and up to now, only two cases have been reported in the literature. Herein, we report synovial chondromatosis of the shoulder joint in a child with both intraarticular and extraarticular involvement. To the best of the authors' knowledge, this is the first case in the literature with both intra- and extra-articular involvement of synovial chondromatosis of the shoulder joint in children. Key Words Synovial chondromatosis, Metaplasia, Children.