Rosendalboone0751

Standalone BLAST search against DrugBank FDA approved drug targets revealed eight proteins that are finally considered druggable proteins. selleck compound Prediction of three-dimensional structures was done for the eight proteins through homology modeling and the Ramachandran plot model showed six models as a valid prediction. Finally, virtual screening against MurB protein was performed using FDA approved drugs to employ the drug repositioning strategy. Three drugs showed promising docking results that can be used for therapeutic purposes against W. chondrophila following the clinical validation of the study.This study was conducted to identify the challenges of crop production and marketing in southwest Ethiopia. Primary and secondary sources of data were used. Qualitative and Quantitative data types were collected from 385 respondents through interviews, focus group discussion, key informant interviews, and observations. The collected data were analyzed by using descriptive statistics and econometric models. Crop productivity was analyzed by the Cobb Douglas model and its efficiency and determinants were identified by the stochastic frontier model. The major bottlenecks of crop production were the low attitude of farmers towards improved technology, low supply and usage of improved seed varieties (94.5%), low supply and use of fertilizers (95%), knowledge and skill gap of farmers (80.1%), poor extension service (57.3%), soil acidity (94.8%), diseases and insect pest (77.8%), conflict (84.9%) and the outbreak of human diseases (60%). Marketing challenges were poor infrastructure (87.3%), lack of market linkage (62.5%), and lack of credit services (70.6%). The Cobb Douglas model result revealed that land size, local seed, improved seed, repetition of weeding, and labor force influenced crop productivity. The mean level of crop technical efficiency was 51.3%. Education level, extension service, access to credit, cooperative membership, number of livestock owned, and soil fertility were influenced crop inefficiency negatively and distance to the farm was positively related to technical inefficiency. Improving extension services and skill of farmers through practical based training and building capacity of extension workers and systems to enhance the attitude of farmers towards technology usage and proper management practices, timely provision of farm inputs, improving road and market access, and provision of credit services to producers were some of the recommendations forwarded to alleviate crop production and marketing challenges in the study areas.This paper discusses the first experiences and results of a project titled Social Fair Play (SFP), whose objective is to install the principles of sustainability and social responsibility (SR) at the core of Spanish professional football. The project was implemented in clubs and foundations belonging to some of the categories of the Spanish National Professional Football League (LaLiga). Generally speaking, the football industry, despite its strong economic and social impact, has entered the debate on strategic management in SR late. This study's interest lies in determining whether these first results and evidences can contribute to the debate, reflected in the specialised literature, around the gap between the theoretical formulation and the practical application of SR and sustainability principles. A second source of interest is the question of whether, on the basis of this experience, a system of social performance measures can be developed for the whole industry which would enable us to compare results and ease their communication, along the lines of other economic sectors, taking as a model internationally recognised standards such as the GRI.Inhibitors of Keap1 would disrupt the covalent interaction between Keap1 and Nrf2 to unleash Nrf2 transcriptional machinery that orchestrates its cellular antioxidant, cytoprotective and detoxification processes thereby, protecting the cells against oxidative stress mediated diseases. In this in silico research, we investigated the Keap1 inhibiting potential of fifty (50) antioxidants using pharmacokinetic ADMET profiling, bioactivity assessment, physicochemical studies, molecular docking investigation, molecular dynamics and Quantum mechanical-based Density Functional Theory (DFT) studies using Keap1 as the apoprotein control. Out of these 50 antioxidants, Maslinic acid (MASA), 18-alpha-glycyrrhetinic acid (18-AGA) and resveratrol stand out by passing the RO5 (Lipinski rule of 5) for the physicochemical properties and ADMET studies. These three compounds also show high binding affinity of -10.6 kJ/mol, -10.4 kJ/mol and -7.8 kJ/mol at the kelch pocket of Keap1 respectively. Analysis of the 20ns trajectories using RMSD, RMSF, ROG and h-bond parameters revealed the stability of these compounds after comparing them with Keap1 apoprotein. Furthermore, the electron donating and accepting potentials of these compounds was used to investigate their reactivity using Density Functional Theory (HOMO and LUMO) and it was revealed that resveratrol had the highest stability based on its low energy gap. Our results predict that the three compounds are potential drug candidates with domiciled therapeutic functions against oxidative stress-mediated diseases. However, resveratrol stands out as the compound with the best stability and therefore, could be the best candidate with the best therapeutic efficacy.Chia seed is expanding on the market due to its characteristics, but there are few studies on its response to residual fertilization of other crops. The objective was to evaluate the vegetative and productive parameters of common bean as a function of the base fertilization increment and to verify the influence of the residue of this fertilization on the development of chia. The experiment was carried out in two stages, Maringá State University, Umuarama Regional Campus, in a randomized block design with 4 replications. The treatments for the first stage were T1 - doses recommended for beans and T2, T3, T4 and T5, were recommended doses for beans with increments for each treatment. The evaluated variables were shoot dry matter, number of pods per plant, grains per plant, grains per pod, 1000 grains weight and yield. In the second stage, the experiment was installed in the same place of the previous cultivation. The treatments were residual bean fertilization, T6 - plus the treatment with the recommendation for chia.