Roseklemmensen7503

Tinnitus assessment is a precursor for individualized treatment and outcome measurement. check details In the recent years, several studies proposed two-alternative forced choice (2AFC) recursive matching as a method to determine tinnitus pitch-match frequency in a standardized reliable manner. Currently, pure tones are used as comparison stimuli to assess pitch-match frequency. In this study, we investigated the psychometric quality of the method comparing different sound types. We measured 20 chronic tinnitus patients in 2 runs on 3 days. To assess pitch-match frequency, we used 2AFC recursive matching and compared results between pure tones and narrow band noise (NBN). Test-retest reliability between runs and across sound types was high (α>0.9) and increased across days. Perceived matching difficulty and time to completion decreased over repetitions. Importantly, the difference of matched frequencies (DMF) between runs was significantly less for NBN. When patients matched the spectral bandwidth of a test tone to their tinnitus, consistency was high (α=0.86) and no patient indicated continuously a pure tone. In conclusion, we recommend using NBN sounds in 2AFC recursive matching to assess pitch-match frequency as a standardized reliable method. Such a procedure could be offered as smartphone-based application to monitor tinnitus symptomatology for individualized assessment and treatment outcome.

Residual Inhibition is considered as tinnitus alteration immediately after exposure to sound. Its clinical significance and correlation with the pathophysiology and treatment prognosis of tinnitus remain enigmatic. The objective of this review is to critically appraise scientific evidence regarding the residual inhibition prevalence and how it is correlated with different sound stimuli.

A systematic review of tinnitus Residual Inhibition (RI) studies was performed, focusing on prevalence, methods used, stimuli presented and responses obtained. A literature search (PubMed, Cochrane Central Register of Controlled Trials, Scopus, MEDLINE) was conducted. Seventeen studies involving 1066 patients fulfilled the inclusion criteria. Sound stimulation was performed using pure tones, customized sounds, narrow- and broadband noises, and modulated sounds.

Sound stimuli exposure produced complete RI of tinnitus in 34.5% of patients (range 5.6-72%), with higher RI rates after stimulation with pure tones and narrowband noise centered to the tinnitus perceived pitch. RI duration tends to increase when stimuli duration increases.

RI is frequent and can be induced by narrow-band noise (NBN), broadband noise (BBN), pure tones, customized sounds and modulated sounds. Adequate evidence to support the use of RI as a tool for tinnitus phenotyping or as a management option is pending. Further clinical research exploring the profile of patients with RI and its potential use as prognostic factor should be conducted.

RI is frequent and can be induced by narrow-band noise (NBN), broadband noise (BBN), pure tones, customized sounds and modulated sounds. Adequate evidence to support the use of RI as a tool for tinnitus phenotyping or as a management option is pending. Further clinical research exploring the profile of patients with RI and its potential use as prognostic factor should be conducted.Direct Torque Control (DTC) scheme introduces a robust and simple control of electrical drive. However, its shortcomings such as broad torque ripple and variable switching frequency have offered several improvements like Space Vector Modulation (SVM) strategy, multilevel inverter (MLI) topology, etc. The conventional DTC which is fed by the two-level inverter has limited voltage vector, results in some difficulties to optimize the operation, especially at low operating speed. In contrast to MLI, the abundant of voltage vector has provided various amplitudes and angles that can overcome the problem of conventional DTC. Thus, this paper introduces the selected optimal voltage vector obtained from five-level Cascaded H-Bridge (CHB) inverter that employs in DTC hysteresis-based to achieve better optimization that similar to the DTC-SVM. Initially, the research work begins with an investigation on the performance comparison between a DTC hysteresis-based between two-level inverter (conventional method) and a five-level CHB inverter (proposed method). Here, a DC generator acted as a load is employed to control the operating speed instead of the speed controller (speed controller is negligible). Hence, the DTC method is optimized by minimizing the torque ripple as well as retaining the torque control capability at constant torque region on several operating speed. The selected optimal vector from the look-up table DTC of five-level CHB inverter must be dynamically appropriate to any change of torque (increased or decreased torque). For simplicity, this paper will only discuss the experimental results for both topologies of drive system. From the experimental results, it is verified that the torque ripples by the proposed method have achieved 10% and 50% reduction at high and low operating speed respectively. It is found that the DTC hysteresis-based result simpler control method than DTC-SVM while maintaining similar output performance.Apoptosis, also named programmed cell death, is a fundament process required for morphogenetic homeostasis during early development and in pathophysiological conditions. It is come into existence in 1972 by work of Kerr, Wyllie and Currie and later on investigated during the research on development of the C. elegans. Trigger by several stimuli, apoptosis is necessary during the embryonic development and aging as homeostatic mechanism to control the cell population and also play a key role as defense mechanism against the immune responses and elimination of damaged cells. Cancer, a genetic disease, is a growing burden on the health and economy of both developing and developed countries. Every year there is tremendously increasing in the number of new cancer cases and mortality rate. Although, there is a significant improvement have been made in biotechnological and bioinformatic fields however, the therapeutic advantages and cancer etiology is still under explored. Several studies determined the deregulation of different apoptotic components during the cancer development and progression.