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Cisplatin is a chemotherapeutic agent against solid cancers. However, neuropathy is a major side effect and has no effective treatment so far. Emerging evidence suggests that cisplatin might damage nerve capillaries leading to impaired blood-nerve barrier (BNB). This study aimed to investigate the ultrastructural changes of the BNB in the sciatic nerves and dorsal root ganglia of rats with cisplatin neuropathy and the effects of B₁₋₆₋₁₂. The results showed that cisplatin 2 mg/kg injected intraperitoneally twice a week for 5 consecutive weeks caused thermal hypoalgesia and structural abnormalities of nerves and ganglia. Co-treatment with oral B₁₋₆₋₁₂ (1001001) 100, 300 and 600 mg/kg/day for 5 weeks reduced the sensory deficit and structural alterations. EM analysis demonstrated the higher frequencies and wider distances of pericyte detachment in the capillaries of cisplatin than control groups. B1-6-12, especially the medium dose, reversed these abnormalities. Culture of endothelial cells and pericytes with cisplatin demonstrated reduced cell viability, increased caspase-3 activity, lower transendothelial electrical resistance and decreased expression of tight junction proteins, occludin and zonula occluden-2 (ZO-2). B1-6-12 could correct these toxic effects of cisplatin. These data confirm that cisplatin causes pathological alterations in the components of BNB which correlate with the severity of neuropathy. Furthermore, B1-6-12 is effective against these abnormalities and deserves further investigations as potential treatment for cisplatin-induced neuropathy.

The aim of this study was to evaluate the effects of repairment of traumatic tympanic membrane perforation (TTMP) with cigarette paper patch (CPP) on perforation closure and hearing functions.

A retrospective evaluation was made of 67 ears of 61 patients diagnosed with TTMP and treated with CPP in our clinic between January 2015 and 2019. In the classification of TTMP size, the entire tympanic membrane was evaluated as 100%, perforation of <25% was considered small, perforation of between 25% and 50% was considered medium and perforation of ≥50% was considered large. Audiological examination was performed before and at 3 months after the CPP procedure. Air conduction (AC) and bone conduction (BC) pure tone averages (PTAs) and air-bone gap (ABG) at 0.5, 1, 2, and 4 khz frequencies were compared.

Perforations were small in 20 (29.9%) of 67 ears, medium in 27 (40.2%), and large in 20 ears (29.9%). AC PTA before CPP was found to be 28.26±5.63 dB hearing level (HL), BC PTA was 8.80±4.35 dB HL and ABG was ent method in terms of both perforation closure and hearing gain.It is important to detect hepatic adenomas, which are generally well-confined lesions, as urgent treatment is required due to the risk of bleeding and conversion to malignancy. Dimensions can vary between 1 and 15 cm, and the risk of hemorrhage is higher in large and multiple-focus adenomas. selleck kinase inhibitor The case is here presented of a patient with spontaneous ruptured liver adenoma after selective transcatheter arterial chemo-embolization for reduction of tumor mass, with discussion of the clinical, computed tomography, angiographic findings, and treatment strategies.

We aimed to investigate antioxidant and neuroprotective properties of chlorogenic acid in spinal cord injury (SCI).

Twenty-one rats were divided into three groups. Laminectomy was performed in group L (n=7), spinal cord trauma was induced in group T (n=7), and spinal cord trauma was induced and chlorogenic acid treatment was started in group C (n=7). Blood samples were collected to analyze baseline values and the 12th h, 1st day, 3rd day, and 5th day catalase, native thiol (NT), total thiol (TT), disulfide (SS), SS/TT, SS/NT, and NT/TT levels. Functional analysis with Basso-Beattie and Bresnahan scores was performed at the same time points. Total antioxidant status (TAS), total oxidative stress, oxidative stress index, and cyclooxygenase-2 (Cox-2) were examined in the spinal cord of rats euthanized on day 7; results were statistically analyzed.

On day 7, catalase levels in Group C were significantly higher than baseline levels, whereas those in Group T were significantly lower than baseline levels; Group L showed no significant difference (p=0.008). SS values on day 7 were lower in Group T than in Groups C and L. Group C showed the lowest decrease in NT/TT level after trauma. On day 7, SS/TT level was high in Group T but stable in Groups C and L (p=0.04). Histopathological examination revealed significantly lower Cox-2 and TAS levels in Group C than in Group T (p=0.003, p=0.017, respectively).

In this study, SCI was primarily examined through thiol-SS balance, and it was demonstrated by experimental models that chlorogenic acid has antioxidant and neuroprotective effects in SCI.

In this study, SCI was primarily examined through thiol-SS balance, and it was demonstrated by experimental models that chlorogenic acid has antioxidant and neuroprotective effects in SCI.

Our hypothesis is that glucose-potassium (GLU/K) ratio can be used to predict morbidity and mortality in the evaluation of patients with blunt abdominal trauma in emergency departments. The aim of the study is to demonstrate the effect of changes in serum GLU/K ratio on morbidity and mortality and to ensure that patient management is performed more quickly and effectively.

The hemogram and biochemical parameters of 99 patients with isolated blunt abdominal trauma, applied to our hospital between January 2016 and January 2020, have been retrospectively reviewed. Patients were divided into two groups as non-survivors and survivors. The GLU/K ratio was calculated, and their ability to predict mortality and morbidity was statistically evaluated between the groups.

In the non-survivor (mortal) group; blood urea nitrogen, serum creatinine, serum GLU and GLU/K ratio were statistically higher than the living group (p<0.005). Moreover, the sensitivity and specificity of the serum GLU/K ratio were found 72.7% and 84.1% respectively.

We think that serum GLU/K ratio can have an important role in the follow-up and management of patients using it as a simple, quickly accessible, and easy predictor in evaluating patients with blunt abdominal trauma.

We think that serum GLU/K ratio can have an important role in the follow-up and management of patients using it as a simple, quickly accessible, and easy predictor in evaluating patients with blunt abdominal trauma.

Although elective operations in general surgery clinics were postponed during the pandemic, non-deferrable operations such as emergency trauma, acute abdominal, and cancer surgeries continued. We aimed to present emergency and non-deferrable elective surgery cases in our hospital's general surgery clinic during the pandemic, to identify the general surgery patients that pose the greatest risk for healthcare workers who served these patients, and to share our experience in these situations.

The study was designed as a retrospective cohort study. The study included patients admitted for emergency and non-deferrable elective surgeries in Kartal Dr. Lutfi Kirdar City Hospital in Istanbul between March 10, 2020, and May 23, 2020. The patients were tested before the operation for severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection. They were also routinely checked for fever and coronavirus disease 2019 (COVID-19) symptoms during dressing changes and outpatient follow-up visits after der risk of infection during the operation.Paraduodenal hernia (PDH) is a rare congenital anomaly, the most common cause of internal hernia. The left-sided PDHs (LPDHs) are more common than the right-sided and are common in male patients at the 4th and 6th years of life. LPDH is been often clinically asymptomatic and often detected by chance in surgical patients. Abdominal computed tomography is the gold standard in diagnosis. PDH can cause ischemia with the high mortality rates due to intestinal obstruction. Therefore, surgical repair should be done as soon as possible after diagnosis. Here, we present a case of LPDH that was laparoscopically diagnosed and repaired early.

This study aims to compare the waiting and operating times of the patients who applied to our hospital with the diagnosis of acute appendicitis (AA) during the pandemic, how the process was managed in terms of AA and other data of the patient compared to the pre-pandemic period.

A retrospective cohort analysis was performed among patients who were hospitalized in the Fatih Sultan Mehmet Training and Research Hospital General Surgery Clinic with a pre-diagnosis of AA. For this purpose, two groups were formed. Group 1 It comprised patients who were operated between March 11 and June 1, 2020; Group 2 It comprised patients who were operated between March 11 and June 1, 2019, with a pre-diagnosis of AA.

Forty-six patients in Group 1 and 79 patients in Group 2 were operated with the pre-diagnosis of AA. There was no difference between groups in terms of pre-operative symptom durations or surgery waiting times.

During the COVID-19 pandemic, significant decrease observed in the number of patients operated because of AA can be interpreted as the avoidance of patients from applying to the hospital with the concern of infection. Moreover, it may suggest that uncomplicated cases undergo spontaneous resolution; however, there is a requirement for further research to support this assumption and define the criteria for this condition by including a level of scientific evidence.

During the COVID-19 pandemic, significant decrease observed in the number of patients operated because of AA can be interpreted as the avoidance of patients from applying to the hospital with the concern of infection. Moreover, it may suggest that uncomplicated cases undergo spontaneous resolution; however, there is a requirement for further research to support this assumption and define the criteria for this condition by including a level of scientific evidence.Splenosis describe a clinical entity of autotransplantation after removal of the spleen secon-dary to a traumatic rupture or surgery. A 39-year-old female was referred to thoracic surgery department with complaints of severe chest pain. She had left thoracic and abdominal gun-shot injury that occurred 19 years earlier. Thorax computed tomograhy and thorax magnetic resonance imaging revealed pleural lesions. A video thoracoscopic biopsy disclosed splenosis in the patient. Splenic implants did not change in 6 years. The patient has mild thoracic pain. Thoracic splenosis can occur in patients who underwent abdominothoracic gunshot injury. The implants did not seem to change in long-term follow-up. Thoracic splenosis may occur, persist for years and it mimics pleural tumor after abdominal gun-shot injury and does not seem to necessitate any surgical intervention including diaphragmatic repair.

Cleft lip/palate (CLP) deformity is the most common congenital facial anomaly. In this study, it was aimed to evaluate the changes in volume and shape of Vomer bone after CLP repair surgery.

The images of a total of 30 patients aged between 9 and 12 years which were recorded with computed tomography were retrospectively analyzed. The patients were divided into three groups No syndrome, operated for unilateral CLP group (n=10), no syndrome, operated for bilateral CLP group (n=10), and control group (n=10) with no syndrome, no operation history, or no lip/palate deformities. Data of the patients were transferred to a software program and a new three-dimensional image was created for the Vomer.

There was no statistically significant difference in the Sella-Nasion lengths, Vomer base lengths, and Vomer vertical lengths among the three groups. However, the Vomer bone volume of the patients with bilateral CLP was found to be statistically significantly higher than the control group.

We can conclude that more bone formation may be observed due to the periosteal reaction following bilateral Vomer flap elevation or during maxillary growth, tension on the palatal flap may be increased new bone formation by pulling the bilateral Vomer flap if it is elevated and sutured palatal mucoperiosteal flap in the early period.