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Potential under-prescribing of pegfilgrastim was also observed. In this literature search, data that appear to support same-day administration of pegfilgrastim were from uncontrolled studies that were limited in size. Analyses of healthcare claims data clearly favored next-day use, with statistically significant increases in FN incidence among patients receiving same-day pegfilgrastim versus those treated 1-4 days post-chemotherapy. Earlier-than-recommended administration typically occurs at the physician's discretion where next-day administration might present barriers to the patient receiving supportive therapy.There is a need to ensure appropriate prescribing to optimize patient outcomes, as deviation from the guideline recommendations was associated with increased incidence of FN and hospitalization.

Signet ring cell carcinoma (SRCC) is a distinct malignancy occurring across the tubular gastrointestinal tract (tGIT). We comprehensively examined the outcomes of patients diagnosed with SRCC across tGIT.

SRCC and not-otherwise-specified adenocarcinoma (NOS) patients reported to the National Cancer Database from 2004 to 2015 were included. Baseline characteristics, outcomes and site-specific adjusted hazard ratios (aHR) derived from Cox models of SRCC patients were compared to those of NOS patients. FB23-2 nmr Overall survival (OS) was primary endpoint.

A total of 41,686 SRCC (4.6%) and 871,373 NOS patients (95.4%) were included. SRCC patients were younger (63.1±14.7vs. 67.0±13.4 y, p<0.001) and more likely to present with Stage IV disease than NOS patients (42.5% vs. 24.5%, p<0.001). Stomach (n=24,433) and colon (n=9,914) contributed highest frequency of SRCC. SRCC histology was associated with shorter OS (aHR=1.377, p<0.001) in multivariate model. There was an interaction between SRCC and chemotherapy effects on risk of death (interaction aHR=1.072, p

<0.001) and between SRCC histology and disease site, suggesting that the effect of SRCC on OS is site-dependent, with a higher increased risk of death in patients with rectal SRCC (aHR=2.378, p

<0.001).

Significant negative prognostic effect associated with SRCC is site-dependent across the GIT. Surgical and or systemic therapy was associated with improved OS among SRCC patients, but remained lower than NOS patients. Further understanding of gastrointestinal SRCC molecular profile is needed to better inform future treatment strategies.

Significant negative prognostic effect associated with SRCC is site-dependent across the GIT. Surgical and or systemic therapy was associated with improved OS among SRCC patients, but remained lower than NOS patients. Further understanding of gastrointestinal SRCC molecular profile is needed to better inform future treatment strategies.This report describes a Swedish translation and psychometric evaluation of the Experience of Embodiment Scale (EES; Piran, Teall, & Counsell, 2020), an instrument for assessing a wide range of positive and negative experiences of living in the body. A community sample (N = 545) of Swedish young women (56%) and men (Mage = 24.4; SD = 0.52) completed the Swedish translation of the EES. To explore its construct validity, participants also completed measures of body esteem, disordered eating, internalization of appearance ideals, drive for muscularity and leanness, body mass index, life satisfaction, self-esteem, and psychological distress. Exploratory factor analyses (performed separately for women and men) revealed structures of the Swedish EES similar to those displayed during the development and first evaluations of the scale in North America. However, among men, the factors of agency and sexual desire combined to form one factor. On total scale level, the Swedish EES showed good internal consistency (McDonald's ω = .95 for women; ω = .94 for men), convergent validity, and incremental validity. Overall, the present findings support the Swedish version of the EES and the EES's cross-national use to assess the construct of embodiment, as well as its use among men.Although weight stigma and discrimination are associated with increased body dissatisfaction and eating disorder risk, reduced opportunities, and poorer well-being, there are few legal protections for such discrimination in the U.S. We addressed one barrier to enacting protective legislation - public attitudes toward anti-weight discrimination laws - by assessing the impact of media representations of fatness and information about peer attitudes. Using a 2 × 2 experimental design, participants (N = 525) completed baseline assessments of political conservatism and weight bias and were randomly assigned to view fat-negative or fat-positive media content that was ostensibly supported or not supported by their peers, followed by questionnaires assessing fat phobia and legislative attitudes. Two-way ANCOVAs controlling for baseline weight bias and political conservatism indicated a significant effect for media framing, with greater fat phobia and less support for anti-discrimination laws and policies among those who viewed the fat-negative frame; however, effects for ostensible peer support and interaction effects were not significant. These preliminary findings suggest that efforts to shift media rhetoric may enhance support for anti-weight discrimination laws. Future research should investigate other barriers to anti-discrimination legislation and estimate their impact on body dissatisfaction, eating disorder risk, and other indicators of population health.Traffic jams are a burden in urban areas, being time-consuming and contributing to stressful driving and CO2 emissions. To implement the United Nations' 2030 agenda for sustainable development, governmental strategies aim to accelerate the shift to sustainable and smart mobility. Consequently, e-micromobility (EMM) appeared as a practical solution for short-distance commuters, and it is growing at upsetting rates thanks to the introduction of sharing services. In fact, urban mobility has drastically changed over the last decade, and electric mobility and micromobility changed the panorama in larger metropolises, given their accessibility, large availability, and the potential to be a time saver in short trips and a potentially sustainable alternative in particular scenarios. The downside of portable e-transportation is the rapid increase in injuries and fatalities. Focusing on standing e-scooters, head injuries are becoming one of the most common as shown by research conducted in different urban emergency depof protective equipment for sharing services are the main barriers to helmet use among riders. Mitigation measures have been implemented by the EMM sharing companies to improve the safety of its users by checking if they wear helmets and by offering vehicle-integrated solutions.Lead (Pb) is a ubiquitous environmental pollutant and a potent toxic compound. Humans are exposed to Pb through inhalation, ingestion, and skin contact via food, water, tobacco smoke, air, dust, and soil. Pb accumulates in bones, brain, liver and kidney. Fetal exposure occurs via transplacental transmission. The most critical health effects are developmental neurotoxicity in infants and cardiovascular effects and nephrotoxicity in adults. Pb exposure has been steadily decreasing over the past decades, but there are few recent exposure data from the general European population; moreover, no safe Pb limit has been set. Sensitive biomarkers of exposure, effect and susceptibility, that reliably and timely indicate Pb-associated toxicity are required to assess human exposure-health relationships in a situation of low to moderate exposure. Therefore, a systematic literature review based on PubMed entries published before July 2019 that addressed Pb exposure and biomarkers of effect and susceptibility, neurodevelopm) during brain development induces impairment of learning and memory abilities") of the AOP-Wiki. Further studies are needed to validate sensitive, reliable, and timely effect biomarkers, especially for low to moderate Pb exposure scenarios.Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are pollutants of worldwide concern that threaten human health and ecosystems. Anthropogenic activities and wastewater could be ARB and ARG pollution sources; however, research on ARG abundance and microbial source tracking (MST) of contamination in tropical marine waters is limited. This study examined spatiotemporal variations of six ARGs (blaNDM, blaTEM, blaVIM, mcr-1, sul1, and tetQ) against the widely used antibiotic groups and a class 1 integron-integrase gene (intI1) at two Thai tropical recreational beaches (n = 41). Correlations between ARGs and sewage-specific MST markers (i.e., crAssphage and human polyomaviruses [HPyVs]) and fecal indicator bacteria (i.e., total coliforms, fecal coliforms, and enterococci) were also investigated. BlaTEM, intI1, sul1, and tetQ were ubiquitous at both beaches (85.4-100% detection rate); intI1 was the most abundant (3-6 orders in log10 copies/100 mL), followed by blaTEM (2-4 orders), sul1 (2-3 orders), and tetQ (2-4 orders). BlaNDM was found in 7.3% (up to 4 orders), and no mcr-1 was detected. Interestingly, blaVIM was prevalent at one beach (2-5 orders; n = 17), but found in only one sample at the other (4 orders). Temporal, but not spatial, differences were noticed; blaTEM was at higher levels in the wet season. IntI1 correlated with sul1 and tetQ (Spearman's rho = 0.47-0.97), suggesting potential horizontal gene transfer. CrAssphage, but not HPyVs, correlated with intI1, sul1, and tetQ (Spearman's rho = 0.50-0.74). Higher numbers of ARGs tended to co-occur in samples with higher crAssphage concentrations, implying sewage contribution to the marine water, with a persisting ARG background. This study provides insight into the ARG pollution status of tropical coastal waters and suggests crAssphage as a proxy for ARG pollution, which could facilitate effective management policies to minimize ARG dissemination in marine environments.

Our study sought to assess the interplay of family dynamics, namely familial warmth and LGBTQ+specific rejection, and its association to self-esteem in a non-probabilistic sample of LGBTQ+adolescents in the United States.

Stratified by (1) cisgender and (2) transgender and non-binary LGBTQ+adolescents (N=8774), we tested multivariable regression analyses to assess the association between familial warmth and LGBTQ+specific family rejection, adjusted for sociodemographic characteristics. We then conducted a sub-analysis with LGBTQ+adolescents who reported being out to any family member about their LGBTQ+identity; specifically, we tested a series of multivariable regression models to assess whether levels of LGBTQ+specific family rejection attenuated the association between familial warmth and self-esteem.

Full sample models indicated a positive association between familial warmth and self-esteem. Findings from our sub-analysis indicated that familial warmth remained positively linked to self-esteem and faerage activities that support positive family dynamics and self-esteem among LGBTQ + adolescents.Prescription central nervous system depressants, opioid pain relievers, and stimulants provide therapeutic value, but misuse for their recreational value is a growing problem in the United States. Because health insurance lowers the cost of purchasing prescription drugs, losing coverage may cause individuals to forgo treatment and decrease prescription drug consumption which could reduce health and increase the likelihood of overdose and death if individuals substitute to using illicit drugs. I estimate the reduced form effect of aging out of the federal dependent coverage mandate at age 26 on legal purchases of prescription central nervous system depressants, opioids, and stimulants. Individuals are 0.5-0.9% points less likely to purchase a prescription central nervous system depressant and 0.8-1.5% points less likely to purchase a prescription opioid after turning 26. These effects are strongest for women, while estimated effects for men are generally negative but imprecise.