Rindommann5463

Compared with group S, groups Au and Al had significantly shorter aortic diameters (group S vs Au vs Al; 2.29 vs 1.40 vs 1.36 mm, respectively, p less then 0.01), reduced MMP-2 and MMP-9 activities, downregulated IL-6 and MCP-1 and upregulated expression of IGF-1 and TIMP-2. There were no differences in these results between groups Au and Al. Thus, our study suggests that treatment with allogeneic MSCs improves chronic inflammation and reduced aortic dilatation. These effects were equivalent to those of autologous MSCs in established mouse models of AA.The diversity of aquatic ecosystems impacted by toxic metals is widely distributed throughout the world. The application of metallothionein (MT) as an early warning sign of metal exposure in freshwater fish is important in biomonitoring, but a more accessible, sensitive, safe, and efficient new methodological strategy is necessary. On this way, a fish MT synthetic gene from Oreochromis aureos was expressed in Escherichia coli to produce polyclonal antibodies against the protein. In the validation assays, these antibodies were able to detect hepatic MT from freshwater fishes Oreochromis niloticus, Pimelodus maculatus, Prochilodus lineatus, and Salminus brasiliensis showing a potential tool for toxic metals biomarker in biomonitoring of aquatic ecosystems. The current results showed the applicability of this molecule in quantitative immunoassays as a sensor for monitoring aquatic environments impacted by toxic metals. Due to the lack of methods focusing on metal pollution diagnostics in aquatic ecosystems, the current proposal revealed a promising tool to applications in biomonitoring programs of water resources, mainly in Brazil where the mining activity is very developed.China's economic development practices are facing strict energy constraints and severe environmental pollution. Improvement of China's environmental total factor productivity (ETFP) through innovation is a major scientific focus of both policy-makers and academia. However, the boundary conditions where innovation affects ETFP are yet to be clarified. On this basis, the present study starts from two dimensions-policy context and market context, introduces economic policy uncertainty (EPU) and marketization process as moderating variables, and examines the impact mechanism of innovation on ETFP. The results show the following (1) Innovation promotes ETFP. (2) Although EPU inhibits ETFP, it positively moderates the impact of innovation on ETFP. (3) The marketization process has an insignificant inhibitory effect on ETFP. Specifically, the development of product markets, the development of market intermediary organizations, and the legal system environment have a significant inhibitory effect on ETFP. In contrast, the marketization process positively moderates the impact of innovation on ETFP. (4) The impact of innovation on ETFP exhibits obvious regional heterogeneity. In regions with low pollution intensity, innovation and EPU promotes ETFP. The marketization process inhibits ETFP and shows a positive moderating effect. In regions with high pollution intensity, both innovation and EPU inhibits ETFP. Based on these conclusions, policy-makers should guide companies to increase investment in research and development, improve innovation capabilities, and focus on strengthening energy-saving and environmental protection technologies and process innovations. When formulating and adjusting economic policies, policy-makers should aim promote enterprise innovation and reduce the negative impact of economic policy uncertainty. Policies should fully utilize the decisive role of the market in the allocation of innovative factors and rely on market mechanisms to enhance the positive effect of innovation on regional ETFP.The conservation and management of rain and water in a city environment are a crucial aspect of sustainability. Sponge cities are a solution for the remediation of excessive water consumption, high pollution, and rainstorm waterlogging in urban areas. Perennial ryegrass (Lolium perenne L.) is a common species and promising bioremediation plant for the construction of sponge cities. It could be useful to purify high nitrogen and phosphorus content in wastewater runoff, but its response to high total nitrogen (TN) and total phosphorus (TP) levels has not been studied. The present study aimed to evaluate the effects of high TN + TP level on seed germination, plant growth, antioxidant response, and assimilation rate of N and P in perennial ryegrass. Naporafenib Compared with the control, treatments with 20 mg/L N + 4 mg/L P (20N4P) significantly decreased germination potential at day 3, but the germination rate at day 10 was similar between all treatments and the control, suggesting that a high TN + TP concentration might delay germination, but not prevent it. Treatment with 20N4P also induced significant withering and decreased shoot length, root length, and dry shoot weight of ryegrass seedlings, compared with the control. Treatments with 80N16P significantly decreased levels of chlorophyll a (Chl-a) and chlorophyll b (Chl-b), demonstrating inhibition of photosynthesis. Compared with the control, treatment with 40N8P increased the carotenoid (Car), malondialdehyde (MDA), and glutathione (GSH) content, which might alleviate oxidative stress induced by high TN + TP concentration. Moreover, high levels of TN + TP (160N32P and 320N64P) significantly reduced the removal capacity of N and P by plants. Overall, the present results provide a theoretical foundation for the development of ryegrass for bioremediation of wastewater during construction of sponge cities.This study aimed to examine the impact of financial development and energy consumption on CO2 emissions by employing balanced panel data from the period 1990-2017 for 184 countries worldwide. This study applied seemingly unrelated regression (SUR), two-step difference, and the system GMM model for data analysis. The examined results of SUR, two-step difference, and system GMM show that energy consumption positively impacts the CO2 emissions worldwide; on the other hand, the examined results of two-step difference and the system GMM model indicate that financial development helps to reduce the CO2 emissions and the results of SUR indicate that financial development positively impacts the CO2 emissions. The examined results regarding economic growth indicate a positive effect on the CO2 emission and the square of economic growth verifies the validly of the environmental Kuznets curve in 184 countries. This study has significant implications for policy makers with regard to environment improvement, clean energy conservation, and an efficient financial system.