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According to the results of cluster analysis, 5 groups of patients with different IR levels were identified. 2. In the second group, where non-NAFLD patients predominate, insulin resistance begins to form. 3. Groups III and IV - patients with high HOMA-IR index - had significant ultrasound findings indicating hepatic steatosis. 4. Group V included patients with NAFLD, with high HOMA-IR index and the highest risk of developing T2DM.

Conclusions 1. According to the results of cluster analysis, 5 groups of patients with different IR levels were identified. 2. In the second group, where non-NAFLD patients predominate, insulin resistance begins to form. 3. Groups III and IV - patients with high HOMA-IR index - had significant ultrasound findings indicating hepatic steatosis. 4. Group V included patients with NAFLD, with high HOMA-IR index and the highest risk of developing T2DM.

The aim To investigate the global longitudinal strain (GLS) in patients with preserved left ventricle systolic function and the presence of varying degrees of coronary artery disease.

Materials and methods The study is based on data obtained during a prospective analysis of 131 patients aged 51 to 82 years in the period from January to December 2019,whose complaints indicate coronary heart disease. The main instrumental method of examination was coronary angiography, patients were divided into 3 groups according to the results. The control group (group I) consisted of 30 patients in whom no coronary artery disease was detected; patients with single vessel lesions or non-stenotic coronary atherosclerosis were included into group II (n = 35) and patients with multivessels lesions (n = 66) were included in group III. For each patient, the extent of the lesion was assessed using the SYNTAX Score. The groups were comparable in age, sex and comorbidities.

Results GLS was -19.71 ± 2.22 (SI -18.88 to -20.54%) in the group without coronary lesions, the group with multivessel lesions was the lowest -14.34 ± 3.47 (SI -13.49 to -15.2%). There was a significant correlation between GLS average and LV EF (r = 0.681; p <0.0001), LV ESV (r = -0.576; p <0.0001), EPSS (r = -0.528; p <0.0001). A moderate correlation was observed GLS, linear and volumetric parameters.

Conclusions Global longitudinal strain is recommended for echocardiographic assessment of patients with coronary artery disease, as one of the main areas of application of this technique because its use provides additional information and maybe used in the same patient to assess the treatment.

Conclusions Global longitudinal strain is recommended for echocardiographic assessment of patients with coronary artery disease, as one of the main areas of application of this technique because its use provides additional information and maybe used in the same patient to assess the treatment.

The aim To study the features of the course of gestation and perinatal outcomes of delivery in women with vitamin D lack.

Materials and methods The article presents the results of studies of the characteristics of the course of pregnancy and delivery outcomes in 50 patients with vitamin D lack compared with a group of 50 somatically healthy pregnant women with normal level of 25 (OH) D. In order to establish a lack of vitamin D in pregnant women in the 10-12, 20-22, 30-32 weeks of gestation electrochemiluminiscence method by using a test system EURIMMUN (Germany) in the blood serum level of 25-hydroxycalciferol (25 (OH) D) in pregnant women.

Results When analyzing the structure of complications in women with vitamin D lack during pregnancy and childbirth we found out that risk of premature birth and premature births dominated among all the complications, respectively (58.0% and 36.0%) against (12.0% and 16.0%), p <0.05. https://www.selleckchem.com/products/gw9662.html Vitamin D lack in pregnant women is often associated with a wide range of obstetrd treatment of Vitamin D deficiency in mother and fetus.

The aim To examine the effect of antireflux therapy on the course of COPD.

Materials and methods Under observation were 60 patients who were hospitalized in the «Transcarpathian Regional Clinical Hospital named after Andrei Novak» with a diagnosis of COPD II gr B in combination with GERD and 36 patients diagnosed with GERD who were treated on an outpatient basis. To study the effectiveness of antireflux therapy and its impact on the course of COPD, patients are divided into 2 groups 1 group (main) (n = 60) - patients with COPD in combination with GERD, group 2 (control) (n = 36) - patients with isolated GERD. Patients with positive Helicobacter pylori status received antihelicobacter therapy. Patients in group 1 were divided into subgroups 1a (n = 34) - COPD in combination with esophageal manifestations of GERD and 1b (n = 26) - COPD in combination with extraesophageal manifestations of GERD. Group 1a received complex therapy, which consisted of basic therapy of COPD in combination with antireflux and with rebapimide, group 1b - only basic therapy of COPD in combination with antireflux.

Results After treatment, the clinical signs of GERD significantly decreased in all patients receiving complex therapy, improved the course of respiratory symptoms of COPD. After treatment, patients showed a clinically significant reduction in systemic inflammation, which is best seen in the group with the use of rabipimide.

Conclusions Comprehensive treatment of combined pathology with the use of antireflux therapy has a positive effect not only on the clinical symptoms of the disease, but also on the indicators of external respiratory function in patients with combined COPD and GERD.

Conclusions Comprehensive treatment of combined pathology with the use of antireflux therapy has a positive effect not only on the clinical symptoms of the disease, but also on the indicators of external respiratory function in patients with combined COPD and GERD.

The aim Was increase the effectiveness of treatment in patients with non-alcoholic fatty liver disease (NAFLD) comorbid with chronic obstructive pulmonary disease (COPD) by using ursodeoxycholic acid (UDCA) in combination with ademethionine.

Materials and methods Under observation was 98 patients with a diagnosis of NAFLD and COPD group II or their combination. Patients were divided into 3 groups 1 (n = 36) - COPD + NASH - in addition to standard COPD therapy received UDCA 15 mg / kg / day - 6 months and ademethionine 1000 mg IV once a day for 10 days, followed by oral administration of 500 mg 2 times per day - 20 days, and group 2 (n = 32) - COPD + hepatic steatosis - in addition to standard therapy - UDCA 15 mg / kg / day - 6 months. Group 3 (n = 30) - COPD received standard therapy for COPD.

Results UDCA with ademethionine on the background of standard COPD therapy reduces the clinical manifestations of NAFLD and normalizes liver function. The combination of UDCA with ademethionine not only has a positive effect on the course of NAFLD, but also reduces the intensity of dyspnea, systemic inflammation, improves the external respiration function and reduces anxiety and depression. Patients receiving UDCA + ademethionine for 6 months of follow-up had no exacerbations of COPD.

Conclusions UDCA in combination with ademethionine in COPD courses have a positive effect on the course of NAFLD, and also reduces the intensity of dyspnea, improves the external respiratory function and reduces the frequency of COPD hospitalization.

Conclusions UDCA in combination with ademethionine in COPD courses have a positive effect on the course of NAFLD, and also reduces the intensity of dyspnea, improves the external respiratory function and reduces the frequency of COPD hospitalization.

The aim The article aims toevaluate the possibility of optimizing the state of the autonomic nervous system in almost healthy young females with different component body composition through physicalactivity and sensible nutrition.

Materials and methods The study involved 30 young females. Body weight of women was measured both before and after the proposed weight correction program. Such parameters as body mass index (BMI, kg / m2),fat mass percentage(FMP,%),visceral fat content (VF,unit) and fat free mass content (FFM, %) using a bioimpedance analyser "TANITA BC-601"were measured. Also, the study of the state of the autonomic nervous system (ANS) based on the registration of the rhythmogram using the computer hardware complex "CARDIOLAB" (HAI - Medica) was carried out.

Results Analysis of the results of the study revealed that the regulation of functions in women with suboptimal ratio of adipose and muscle tissues in the body was carried out mainly through suprasegmental levels of regulation (VLF%) and was accompanied by a decrease in the activity of segmental autonomic influences.At the same time, the theoretical assumption about the possibility of correction of autonomic disorders by normalizing adipose and muscle tissueswas experimentally confirmed.Under the influence of a two-month program of body weight correction an increase in the functional activity of the autonomic control loop and improvement of the internal structure of the spectrum of neuroautonomicregulation (reduction of VLF-oscillations and increase of LF-effects and HF-effects) in the examined women were observed.

Conclusions Thus, physical activity and sensible nutrition have a positive effect on the rheology of adipose tissue and the mechanisms of regulation of body functions, so they can be used to correct their disorders.

Conclusions Thus, physical activity and sensible nutrition have a positive effect on the rheology of adipose tissue and the mechanisms of regulation of body functions, so they can be used to correct their disorders.

The aim To evaluate the peculiarity of clinical manifestations of neonatal respiratory distress syndrome (NRDS) in deeply premature infants from mothers with phenotypic markers of undifferentiated connective tissue dysplasia (UCTD).

Materials and methods The study represent the results of a retrospective clinical and statistical analysis of 268 premature birth report card and newborn report sheet. .The main (1 group) included 50 pregnants with obvious phenotypic markers of UCTD, the comparison group (group 2) consisted of 50 pregnant women without phenotypic markers of UDCTD.

Results According to the study, in 12 (24%) pregnant women of the main group at the time of admission to the clinic had contractions,which required specific therapy. Cervical cerclage was performed in 38 (76%) patients of the main group due to the presence of cervical insufficiency (CI). In these cases, the severity of the CI on the Steinber scale was 7.2 ± 0.4 points in the main group against 4.4 ± 0.2 points in the comparison grogs in the fetal period using a non-invasive method of ultrasonography has been confirmed.

Conclusions1.Neonatal respiratory distress syndrome in premature infants is more often associated from mothers with UDCTD. 2. The high importance of steroid prophylaxis of NRDS and antioxidant therapy in reducing the frequency of mechanical ventilation and the development of bronchopulmonary pathology, especially in infants from mothers with UDCTD syndrome, has been proven. 3. The possibility of diagnosing disorders of functional maturation of the lungs in the fetal period using a non-invasive method of ultrasonography has been confirmed.