Reynoldsnorth2525

The good interfacial contact and high lithium ion conductivity provide sufficient lithium deposition sites and uniform lithium ion flux to regulate the lithium deposition without the formation of lithium dendrites. Consequently, the Li2OHBr-containing PEO polymer electrolyte in a lithium-metal battery with a 3D-structured lithium/copper mesh composite anode is able to improve the cycle stability and rate performance. The results of this study provide the experimental proof of the beneficial effects of the Li2OHBr-containing PEO polymer electrolyte on the 3D-structured lithium metal anode.The benefit of enriching solid-electrolyte interface with fluorine atoms through the use of fluorinated additives into the electrolyte composition has recently gained popularity for anode materials used in secondary lithium-ion batteries. Another strategy is to provide these fluorine atoms via surface fluorination of the electrode material, particularly for multiwalled carbon nanotube (MWCNT)/SnO2-based composites where fluorination must act selectively on SnO2. Our study presents two methods of surface fluorination applied on MWCNT/SnO2, one using F2(g) and the other XeF2(s). These fluorinating agents are known for their different particle penetration depths. An ultrathin and very dense fluorinated layer achieved by the action of F2(g) allows to form a very stable interface leading to gravimetric capacities of 789 mA h g-1 after 50 cycles. A thin and porous fluorinated layer made by the action of XeF2(s) favors the formation of a new Sn-based fluorinated phase, never reported in the literature, which also stabilizes capacities over 50 cycles. In any case, the value of adding fluorine atoms to the surface of the electrode material to improve cycle stability is demonstrated.Solid-state lithium metal batteries (SSLMBs), using lithium metal as the anode and garnet-structured Li6.5La3Zr1.5Ta0.5O12 (LLZTO) as the electrolyte, are attractive and promising due to their high energy density and safety. However, the interface contact between the lithium metal and LLZTO is a major obstacle to the performance of SSLMBs. Here, we successfully improve the interface wettability by introducing one-dimensional (1D) TiO2 nanofibers into the lithium metal to obtain a Li-lithiated TiO2 composite anode (Li-TiO2). When 10 wt % TiO2 nanofibers are added, the formed composite anode offers a seamless interface contact with LLZTO and enables an interfacial resistance of 27 Ω cm2, which is much smaller than 374 Ω cm2 of pristine lithium metal. Due to the enhanced interface wettability, the symmetric Li-TiO2|LLZTO|Li-TiO2 cell upgrades the critical current density to 2.2 mA cm-2 and endures stable cycling over 550 h. Furthermore, by coupling the Li-TiO2 composite anode with the LiFePO4 cathode, the full cell shows stable cycling performance. This work proves the role of TiO2 nanofibers in enhancing the interface contact between the garnet electrolyte and the lithium metal anode and improving the performance of SSLMBs and provides an effective approach with 1D additives for solving the interface issues.Catalases (CAT) are antioxidant metalloenzymes necessary for life in oxygen-metabolizing cells to regulate H2O2 concentration by accelerating its dismutation. Many physiopathological situations are associated with oxidative stress resulting from H2O2 overproduction, during which antioxidant defenses are overwhelmed. We have used a combinatorial approach associated with an activity-based screening to discover a first peptidyl di-copper complex mimicking CAT. The complex was studied in detail and characterized for its CAT activity both in solutions and in cells using different analytical methods. The complex exhibited CAT activity in solutions and, more interestingly, on HyPer HeLa cells that possess a genetically encoded ratiometric fluorescent sensors of H2O2. These results highlight the efficiency of a combinatorial approach for the discovery of peptidyl complexes that exhibit catalytic activity.Molecular dynamics (MD) simulations and X-ray absorption spectroscopy (XAS) have been combined to study the coordination of the Co2+ and Ni2+ ions in ionic liquids (ILs) based on the bis(trifluoromethylsulfonyl)imide ([Tf2N]-) anion and having different organic cations, namely, 1-butyl-3-methylimidazolium ([C4mim]+), 1,8-bis(3-methylimidazolium-1-yl)octane ([C8(mim)2]2+), N,N,N-trimethyl-N-(2-hydroxyethyl)ammonium ([choline]+), and butyltrimethylammonium ([BTMA]+). Co and Ni K-edge XAS data have been collected on 0.1 mol L-1 Co(Tf2N)2 and Ni(Tf2N)2 solutions and on the metallic salts. MD simulations have been carried out to obtain structural information on the metal ion coordination. The analysis of the extended X-ray absorption fine structure (EXAFS) spectra of the solutions has been carried out based on the atomistic description provided by MD, and the studied ILs have been found to be able to dissolve both the Co(Tf2N)2 and Ni(Tf2N)2 salts giving rise to a different structural arrangement around the metal ions as compared to the solid state. The combined EXAFS and MD results showed that the Co2+ and Ni2+ ions are surrounded by a first solvation shell formed by six [Tf2N]- anions, each coordinating in a monodentate fashion by means of the oxygen atoms. The nature of the IL organic cation has little or no influence on the overall spatial arrangement of the [Tf2N]- anions, so that stable octahedral complexes of the type [M(Tf2N)6]4- (M = Co, Ni) have been observed in all the investigated ILs.Many creatures have excellent control over their form, color, and morphology, allowing them to respond to the interaction of environmental stimuli better. Here, the bioinspired synergistic shape-color-switchable actuators based on thermally induced shape-memory triethanolamine cross-linked polyurethane (TEAPU) and thermochromic ionic liquids (ILs) were prepared. The thermochromic ILs with various metalized anions, including bis(1-butyl-3-methylimidazolium) tetrachloro nickelate ([Bmim]2[NiCl4]) and bis(1-butyl-3-methylimidazolium) tetrachloride cobalt ([Bmim]2[CoCl4]), are investigated. The actuators exhibit thermochromic response, as evidenced by a shift in the color of the composites, which is due to the formation of the tetrahedral complex MCl42- (M = Ni and Co) after dehydration. Selleckchem CX-5461 The shape-color-switchable thermochromic actuators have strong molecular interaction between TEAPU and ILs and can mimic natural flowers and change the color and shape quickly in a narrow temperature range (30-70 °C). In addition, these thermochromic actuators can lift more than 50 times their weight and withstand strains of more than 1100%. The results represent the potential application in artificial muscle actuators and intelligent camouflages.

The aim of this study was to evaluate the efficiency of buccal spray form of vitamin D compared to single oral dose (stoss therapy) and oral drops therapy in the treatment of vitamin D deficiency.

Ninety healthy children and adolescents (3-18 years) with vitamin D deficiency [serum level of 25-hydroxyvitamin D (25OHD) < 12ng/ml] were randomized to receive vitamin D3 buccal spray (2000 U, n=30, group I) for 6-week period, oral drops (2000 U, n=30, group II) for 6-week period and a single oral dose (300 000 U) vitamin D 3 (n=30, group III). Serum calcium, phosphorus, ALP, PTH and 25OHD levels of the patients were measured at baseline and after the treatment (42

day).

All 3 groups had a significant increase in serum 25 hydroxyvitamin D (25OHD) concentrations (p<0.001). Serum 25OHD concentration in group I was 22.1 (17.8-28.2) ng/ml as compared to baseline value of 8.0±0.41ng/ml, with the mean increase of 15.6±1.3 ng/ml. On the other hand, in group II and group III, the mean serum 25OHD concentrations were 24.4 (20.6-29.6) ng/ml and 40.3 (29.4-58.4) ng/ml as compared to baseline value of 7.9±0.45 ng/ml and 7.6±0.47 ng/ml, with the mean increase of 17.3±1.1ng/ml, 34.3±3.2 ng/ml, respectively.

We conclude that vitamin D3 supplementation with buccal spray and oral drops is equally effective in terms of raising vitamin D concentrations in short-term treatment of vitamin D deficiency.

We conclude that vitamin D3 supplementation with buccal spray and oral drops is equally effective in terms of raising vitamin D concentrations in short-term treatment of vitamin D deficiency.Not available.Shedding of A Disintegrin And Metalloproteinases (ADAM10) substrates, like TNFα or CD30, can affect both anti-tumor immune response and antibody-drug-conjugate (ADC)-based immunotherapy. We have published two new ADAM10 inhibitors, LT4 and MN8 able to prevent such shedding in Hodgkin lymphoma (HL). Since tumor tissue architecture deeply influence the outcome of anti-cancer treatments, we set up new three-dimensional (3D) culture systemsto verify whether ADAM10 inhibitors can contribute to, or enhance, the anti-lymphoma effects of the ADC brentuximab-vedotin (BtxVed).To recapitulate some aspects of lymphoma structure and architecture, we assembled two 3D culture models mixed spheroids made of HL lymph node (LN) mesenchymal stromal cells (MSC) and Reed Sternberg/Hodgkin lymphoma cells (HL cells) or collagen scaffolds repopulated with LN-MSC and HL cells. In these 3D systems we found that 1) the ADAM10 inhibitors LT4 and MN8 reduce ATP content or glucose consumption, related to cell proliferation, increasing lactate dehydrogenase (LDH) release as a cell damage hallmark; 2) these events are paralleled by mixed spheroids size reduction and inhibition of CD30 and TNFα shedding; 3) the effects observed can be reproduced in repopulated HL LN-derived matrix or collagen scaffolds; 4) ADAM10 inhibitors enhance the antilymphoma effect of the anti-CD30 ADC BtxVed both in conventional cultures and in repopulated scaffolds. Thus, we provide evidence for direct and combined anti-lymphoma effect of ADAM10 inhibitors with BtxVed, leading to improvement of ADC effects; this is documented in 3D models recapitulating features of LN microenvironment, that can be proposed as reliable tool for antilymphoma drug testing.

To compare outcomes transferring one or two embryos in autologous frozen oocyte cycles.

A retrospective cohort study conducted at an academic fertility center (January 2012 and December 2018). 114 patients underwent frozen oocyte transfers. 67 patients underwent SET and 47 underwent DET. No subjects had more than DET during the time period of study. Data were analyzed using t test and chi-squared testing. Multivariate logistic regression was used to control for confounding effects. Power analysis suggested an 82% power with alpha of 5% and effect size of 27%.

Regarding the stage, 72 % were cleavage embryos and 28% were blastocyst embryos. Among those who had cleavage stage embryos, 48.8% had SET and 51.2% had DET. In the blastocyst embryos, group 84.4% had SET and 15.6% had DET. There were no statistical differences observed in pregnancy rate for SET (40.3%) vs. DET(36.2%) (P = 0,78). Additionally, the live birth rate was not different between SET (28.4%) & DET(19.1 %) (P= 0.26). The multivariate multilevel analysis provided an adjusted OR- [95% CI] of 1.85-[0.46 - 7.44] for pregnancy, 0.497-[0.05 - 4.86] for clinical pregnancy, and 0.82-[0.11 - 6.29] for live birth when comparing SET & DET. Multiple pregnancy rates were significantly lower in the SET (0%), compared with DET group (44.4%) (p< 0.002).

There are excellent live birth outcomes returning single embryos in autologous frozen oocyte cycles. However DET results in significantly increased rates of multiple pregnancies. As such SET is a viable option in autologous frozen oocyte cycles.

There are excellent live birth outcomes returning single embryos in autologous frozen oocyte cycles. However DET results in significantly increased rates of multiple pregnancies. As such SET is a viable option in autologous frozen oocyte cycles.