Reynoldsclements8997

The possibility to tune, through the application of a control gate voltage, the superconducting properties of mesoscopic devices based on Bardeen-Cooper-Schrieffer metals was recently demonstrated. Despite the extensive experimental evidence obtained on different materials and geometries, a description of the microscopic mechanism at the basis of such an unconventional effect has not been provided yet. This work discusses the technological potential of gate control of superconductivity in metallic superconductors and revises the experimental results, which provide information regarding a possible thermal origin of the effect first, we review experiments performed on high-critical-temperature elemental superconductors (niobium and vanadium) and show how devices based on these materials can be exploited to realize basic electronic tools, such as a half-wave rectifier. Second, we discuss the origin of the gating effect by showing gate-driven suppression of the supercurrent in a suspended titanium wire and by providing a comparison between thermal and electric switching current probability distributions. Furthermore, we discuss the cold field-emission of electrons from the gate employing finite element simulations and compare the results with experimental data. In our view, the presented data provide a strong indication regarding the unlikelihood of the thermal origin of the gating effect.Unsafe behaviors of construction workers are one of the main causes of accidents at construction sites. The research on unsafe behaviors of workers helps to reduce the incidence of accidents and has attracted much attention. However, a systematic literature review in this field is still lacking, which hinders stakeholders' comprehensive understanding of the unsafe behaviors of construction workers. Therefore, the aim of this study is to address this research gap based on retrieved literature from the Web of Science. First, the study conducted a descriptive analysis of the year, quantity, publishing organization, and keywords of the literature. In addition, three research topics were identified and discussed, including the influencing factors of construction workers' unsafe behaviors, the formation mechanism of unsafe behaviors, and the pre-control methods of unsafe behaviors. Moreover, a research framework was proposed and future research directions were also suggested. The research findings promote stakeholders' understanding of the influencing factors, formation mechanism, and pre-control methods of construction workers' unsafe behaviors, and lead to future research directions in the studied field.Low-temperature environments can strongly affect the normal growth and health of livestock. In winter, cold weather can be accompanied by strong winds that aggravate the effects of cold on livestock. In this study, two experiments were conducted to investigate the effect of low temperature and/or wind speed on physiological indices, rumen microbiota, immune responses and oxidative stress in sheep. When sheep were exposed to cold temperature and/or stronger wind speeds, the average daily gain (ADG) decreased (p less then 0.05), and the abundance of Lachnospiraceae was significantly higher (p less then 0.05). The acetate and propionate contents and the proportion of propionate in the rumen also significantly reduced (p less then 0.05). The immunoglobulin G (IgG) and TH1-related cytokines in the blood were significantly lower (p less then 0.05). However, antioxidant enzyme contents were significantly increased and the concentration of malondialdehyde (MDA) was reduced (p less then 0.05). In a cold environment, the abundance of Lachnospiraceae in the rumen of sheep was highly enriched, and the decreasing of propionate might be one of the factors affecting the immunity of the animals, the sheep did not suffer from oxidative damage during the experiment.In this paper, the sustainability of induced healing asphalt pavement is demonstrated by comparing the impact of asphalt pavement maintained by induced healing asphalt pavement technology and traditional maintenance methods (such as milling and overlaying). The functional unit selected is a 1-km lane with an analysis period of 20 years. The stages to be considered are material manufacturing, paving, maintenance, milling and demolition. Two case studies were analyzed to assess the impact of different technologies on the energy consumption and environmental performance of each maintenance alternative. By comparing the energy consumption and environmental emissions of the whole life cycle of pavement under the two technical conditions, the results show that the total energy consumption of traditional asphalt pavement is about 2.5 times that of induction-healed asphalt pavement, and the total greenhouse gas (GHG) emissions of the former are twice as much as that of the latter.This study examined the role of trust in lay people's health behaviors related to the current pandemic. A total of 376 Israelis completed an online questionnaire during the second lockdown. A latent profile analysis was conducted to identify profiles of individuals based on their levels of trust in the various institutions and stakeholders examined in this study. A three-profile solution was deemed most appropriate. The largest profile (N = 178) was characterized by low levels of trust in the government, but high levels of trust in science and one's primary care provider. Next, was the generally low trust profile (N = 108), characterized by low levels of trust directed towards all stakeholders and institutes. Shikonin purchase The third profile (N = 79) was characterized by high levels of trust. Results are discussed in relation to the important role of trust in determining people's response to the current pandemic and the unique features of Israeli society.

The use of teledermatology has spread over the last years, especially during the recent SARS-Cov-2 pandemic. Teledermoscopy, an extension of teledermatology, consists of consulting dermoscopic images, also transmitted through smartphones, to remotely diagnose skin tumors or other dermatological diseases. The purpose of this work was to verify the diagnostic validity of images acquired with an inexpensive smartphone microscope (Nurugo

), employing convolutional neural networks (CNN) to classify malignant melanoma (MM), melanocytic nevus (MN), and seborrheic keratosis (SK).

The CNN, trained with 600 dermatoscopic images from the ISIC (International Skin Imaging Collaboration) archive, was tested on three test sets ISIC images, images acquired with the Nurugo

, and images acquired with a conventional dermatoscope.

The results obtained, although with some limitations due to the smartphone device and small data set, were encouraging, showing comparable results to the clinical dermatoscope and up to 80% accuracy (out of 10 images, two were misclassified) using the Nurugo

demonstrating how an amateur device can be used with reasonable levels of diagnostic accuracy.

Considering the low cost and the ease of use, the Nurugo

device could be a useful tool for general practitioners (GPs) to perform the first triage of skin lesions, aiding the selection of lesions that require a face-to-face consultation with dermatologists.

Considering the low cost and the ease of use, the NurugoTM device could be a useful tool for general practitioners (GPs) to perform the first triage of skin lesions, aiding the selection of lesions that require a face-to-face consultation with dermatologists.Cannabidiol (CBD), a lipophilic cannabinoid compound without psychoactive effects, has emerged as adjuvant of anti-epileptic drugs (AEDs) in the treatment of refractory epilepsy (RE), decreasing the severity and/or frequency of seizures. CBD is considered a multitarget drug that could act throughout the canonical endocannabinoid receptors (CB1-CB2) or multiple non-canonical pathways. Despite the fact that the CBD mechanism in RE is still unknown, experiments carried out in our laboratory showed that CBD has an inhibitory role on P-glycoprotein excretory function, highly related to RE. Since CB2 is expressed mainly in the immune cells, we hypothesized that CBD treatment could alter the activity of polymorphonuclear neutrophils (PMNs) in a similar way that it does with microglia/macrophages and others circulating leukocytes. link2 In vitro, CBD induced PMN cytoplasmatic vacuolization and proapoptotic nuclear condensation, associated with a significantly decreased viability in a concentration-dependent manner, while low CBD concentration decreased PMN viability in a time-dependent manner. At a functional level, CBD reduced the chemotaxis and oxygen consumption of PMNs related with superoxide anion production, while the singlet oxygen level was increased suggesting oxidative stress damage. These results are in line with the well-known CBD anti-inflammatory effect and support a potential immunosuppressor role on PMNs that could promote an eventual defenseless state during chronic treatment with CBD in RE.Protein Kinase CK2 (Casein Kinase 2 or CK2) is a constitutively active serine-threonine kinase overactive in human malignancies. Increased expression and activity of CK2 in Acute Myeloid Leukemia (AML) is associated with a poor outcome. CK2 promotes AML cell survival by impinging on multiple oncogenic signaling pathways. The selective small-molecule CK2 inhibitor CX-4945 has shown in vitro cytotoxicity in AML. Here, we report that CX-4945 has a strong in vivo therapeutic effect in preclinical models of AML. link3 The analysis of genome-wide DNA-binding and gene expression in CX-4945 treated AML cells shows that one mechanism, by which CK2 inhibition exerts a therapeutic effect in AML, involves the revival of IKAROS tumor suppressor function. CK2 phosphorylates IKAROS and disrupts IKAROS' transcriptional activity by impairing DNA-binding and association with chromatin modifiers. Here, we demonstrate that CK2 inhibition decreases IKAROS phosphorylation and restores IKAROS binding to DNA. Further functional experiments show that IKAROS negatively regulates the transcription of anti-apoptotic genes, including BCL-XL (B cell Lymphoma like-2 like 1, BCL2L1). CX-4945 restitutes the IKAROS-mediated repression of BCL-XL in vivo and sensitizes AML cells to apoptosis. Using CX-4945, alongside the cytotoxic chemotherapeutic drug daunorubicin, augments BCL-XL suppression and AML cell apoptosis. Overall, these results establish the in vivo therapeutic efficacy of CX-4945 in AML preclinical models and determine the role of CK2 and IKAROS in regulating apoptosis in AML. Furthermore, our study provides functional and mechanistic bases for the addition of CK2 inhibitors to AML therapy.Titanium alloys and composites are of great interest for a wide variety of industrial applications; however, most of them suffer from poor tribological performance, especially at elevated temperatures. In this study, spark plasma sintering was utilized to produce a fully dense and thermodynamically stable TiB-Ti composite with a high content of ceramic phase (88 wt.%) from self-propagating high temperature synthesized (SHS) powders of commercially available Ti and B. Microstructural examination, thermodynamic assessments, and XRD analysis revealed the in situ formation of titanium borides with a relatively broad grain size distribution and elongated shapes of different aspect ratio. The composite exhibits a considerable hardness of 1550 HV30 combined with a good indentation fracture toughness of 8.2 MPa·m1/2. Dry sliding wear tests were performed at room and elevated temperature (800 °C) under 5 and 20 N sliding loads with the sliding speed of 0.1 m·s-1 and the sliding distance of 1000 m. A considerable decline in the coefficient of friction and wear rate was demonstrated at elevated temperature sliding.