Regancase2185

Therapeutic strategies that successfully combine two techniques-autologous micrografting and biodegradable scaffolds-offer great potential for improved wound repair and decreased scarring. In this study we evaluate the efficacy of a novel modification of a collagen-glycosaminoglycan scaffold with autologous micrografts using a murine dorsal wound model.

db/db mice underwent dorsal wound excision and were treated with a collagen-glycosaminoglycan scaffold (CGS), a modified collagen-glycosaminoglycan scaffold (CGS+MG) or simple occlusive dressing (Blank). The modified scaffold was created by harvesting full thickness micrografts and transplanting these into the collagen-glycosaminoglycan membrane. Parameters of wound healing, including cellular proliferation, collagen deposition, keratinocyte migration, and angiogenesis were assessed.

The group treated with the micrograft-modified scaffold healed at a faster rate, showed greater cellular proliferation, collagen deposition, and keratinocyte migration with healing. Clinically, the successful scaffold engraftment, micrograft viability and improved wound healing offer promising results for the development of a new therapeutic modality for wound repair.In order to improve the electrochemical capacity of lithium-sulfur batteries (LiSBs), it is necessary to introduce the porous organic frameworks with well-defined hetero atom species in cathode. In this work, porous nanomaterials with ultra-high nitrogen containing and adjustable porosity named Schiff-based networks (SNWs) were selected as potential candidate for sulfur host in LiSBs. Two SNW samples have been constructed by reacting melamine with phenyl or biphenyl dialdehydes through microwave-assisted method, respectively. The high BET surface area provided sufficient room to impregnate sulfur and mitigated volume changes during the cycling performance. Besides, the high density and homogeneous distribution of pyridinic-N and aminic-N in SNW nanoparticles can cooperatively form lithium polysulfides (LiPSs) chemisorption via enhanced Li+-N interactions to effectively suppressed the 'shuttle effect'. Attributed to its structural superiorities, SNW/S cathode demonstrates excellent electrochemical performance in LiSBs. In particular, SNW-2/S cathode delivers an excellent cyclability with a specific capacity of 620 mAh · g-1 after 500 cycles at 0.5 C, counting with a low capacity fading of 0.0508% per cycle. This work highlights the importance of rational design for effective LiPSs chemisorption and pioneers a facile strategy for developing suitable sulfur host materials towards high-performance LiSBs.The first-principles electron-hole Lindhard response function has been calculated and analyzed in detail for two (TMTSF)2 X (X = ClO4 and NO3) Bechgaard salts undergoing different anion-ordering (AO) transitions. The calculation was carried out using the real triclinic low-temperature structures. The evolution of the electron-hole response with temperature for both relaxed and quenched salts is discussed. It is shown that the 2k F response of the quenched samples of both salts display a low temperature curved and tilted triangular continuum of maxima. This is not the case for the relaxed samples. (TMTSF)2ClO4 in the AO state exhibits a more quasi-1D response than in the non AO state and relaxed (TMTSF)2NO3 shows a sharp maximum. The curved triangular plateau of the quenched samples results from multiple nesting of the warped quasi-1D Fermi surface which implies the existence of a large q range of electron-hole fluctuations. This broad maxima region is around 1% of the Brillouin zone area for the X = ClO4 salt (and X = PF6) but only 0.1% for the X = NO3 salt. check details It is suggested that the strong reduction of associated SDW fluctuations could explain the non detection of the SDW-mediated superconductivity in (TMTSF)2NO3. The calculated maxima of the Lindhard response nicely account for the modulation wave vector experimentally determined by NMR in the SDW ground state of the two salts. The critical AO wave vector for both salts is located in regions where the Lindhard response is a minimum so that they are unrelated to any electron-hole instability. The present first-principles calculation reveals 3D effects in the Lindhard response of the two salts at low temperature which are considerably more difficult to model in analytical approaches.We have used $ab~initio$ density functional theory to study electronic, mechanical, phononic, and superconducting properties of Li$_2$$M$Si$_2$ ($M$=Ir, Rh), which has recently been produced as a new type of transition metal--based ternary compound in the trigonal structure [Horigane $\it et~al.$, 2019 \textitNew Journ. of Phys. \textbf21 093056]. The calculated electronic band structure and the density of states indicate that the Li$_2$IrSi$_2$ and Li$_2$RhSi$_2$ compounds are in metallic character. Mechanical properties such as elastic constants, bulk modulus, shear modulus, Young's modulus, Poisson's ratio, and Debye temperature were calculated for these compounds. The calculated results suggest that the compounds are mechanically stable and behave in a ductile manner. The phonon spectra have no imaginary frequency, which proves that these compounds are dynamically stable. Electron--phonon coupling parameters confirm that they are weak--coupling superconductors. Although the influence of spin--orbit coupling in superconductivity is not significant for these compounds, it has a very small influence on electronic structure for Li$_2$IrSi$_2$. The calculated critical temperature ($T_c^\mu^\star=0.11$) values of 3.29 K for Li$_2$IrSi$_2$ and 2.82 K for Li$_2$RhSi$_2$ agree well with experimental estimates.Tissue engineering applications typically require three-dimensional scaffolds which provide the requisite surface area for cellular functions, while allowing transport of nutrients, waste and oxygen to and from the surrounding tissues. Scaffolds need to ensure sufficient mechanical properties to provide mechanically stable frameworks under physiologically relevant stress levels. Meanwhile, electrically conductive platforms are also desirable for the regeneration of specific tissues, where electrical impulses are transmitted throughout the tissue for proper physiological functioning. Towards this goal, carbon nanofibers (CNFs) were incorporated into silk fibroin (SF) scaffolds whose pore size and porosity were controlled during a salt leaching process. In our methodology, CNFs were dispersed in SF due to the hydrogen bond-forming ability of hexafluoro-2-propanol, a fluoroalcohol used as a solvent for SF. Results showed enhanced electrical conductivity and mechanical properties upon the incorporation of CNFs into the SF scaffolds, while the metabolic activities of cells cultured on SF/CNF nanocomposite scaffolds were significantly improved by optimizing the CNF content, porosity and pore size range of the scaffolds.