Ratliffomar3663

72; 95% confidence interval [CI] 1.37 - 2.16 for obese vs. normal BMI). The association with obesity was significantly stronger for BRAF-mutation positive than BRAF-negative papillary thyroid cancers (OR = 1.71; 95% CI 1.17 - 2.50 for BRAF positive versus BRAF-negative cancers). The increased risks associated with overweight/obesity did not vary by histological subtypes or presence/absence of adverse tumor histologic features. CONCLUSIONS Greater risk of BRAF-mutated papillary thyroid cancers among those with high BMI suggests that the association may not merely reflect greater healthcare service use and indicates an independent relationship between obesity and clinically important thyroid cancer.BACKGROUND The prevalence and clinical significance of de novo detection of anti-thyroglobulin antibodies (TgAb) during the follow-up of patients with differentiated thyroid cancer (DTC) is unknown. METHODS We utilized the National Thyroid Cancer Treatment Cooperative Study registry (1987-2012). Patients registered after 1996 (n = 3,318) were analyzed. We identified 1,545 subjects who had available TgAb status (TgAb cohort) between years 1996 and 2012, of whom 1,325 were TgAb negative at first post-operative follow-up testing. From this initial TgAb negative group, we excluded 513 patients 423 patients who had less than three-years of follow-up and/or fewer than three follow-up visits, 86 patients with persistent disease after initial treatment, and 4 patients with data entry errors. The remaining 812 patients were included for analysis, comprising the TgAb persistently negative group [defined as TgAb negative for at least three consecutive follow-up visits and at least three-years of follow-up] (n = 772) andnt association between de novo TgAb development and DTC structural recurrence. Larger prospective studies are required to confirm these findings and further assess the significance of de novo TgAb detection in the follow up of DTC.none.No abstract required.BACKGROUND Studies have highlighted the adverse effects of long working hours on workers' health; however, the association of long working hours with thyroid function has not been studied. This study aimed to assess long working hours as a risk factor for thyroid dysfunction. METHODS This cross-sectional study was based on data obtained from the Korea National Health and Nutrition Examination Survey conducted from 2013 to 2015. A total of 2,160 adults who worked 36-83 hours per week were included. Thyroid function was defined based on the population thyroid-stimulating hormone reference ranges, after excluding individuals with positive results for thyroid peroxidase antibody. The association between working hours and thyroid function was confirmed via multinomial logistic regression. RESULTS Hypothyroidism was more prevalent among those with longer working hours (3.5% vs. 1.4% for 53-83 and 36-42 working hours per week, respectively). Individuals who worked longer hours had an increased odds for hypothyroidism (odds ratio 1.46, 95% confidence interval 1.12-1.90, per 10 hour increase in working hours per week), after adjustment for age, sex, body mass index, urine iodine concentration, smoking status, work schedule, and socioeconomic status. The association between working hours and hypothyroidism was consistent in various subgroups stratified by sex or socioeconomic status. CONCLUSIONS To our knowledge, this study is the first to show that long working hours are associated with hypothyroidism. Further large longitudinal studies are needed to clarify causality.There is growing interest in developing magnetic resonance imaging (MRI) biomarkers of brain connectivity from resting-state functional (rs-fMRI) and diffusion tensor imaging (DTI) to aid in the management of patients with mild traumatic brain injury (mTBI). To determine whether early MRI biomarkers of brain connectivity are useful in predicting outcome after mTBI, we conducted a systematic review using the following inclusion criteria (1) patients aged>16 years with mTBI, (2) MRI performed during the first month post-injury, (3) outcome measure available, (4) control group, and (5) original paper published in a peer-reviewed journal. Of the 1351 citations identified, 14 studies met inclusion criteria (5 rs-fMRI and 10 DTI; 680 mTBI patients vs 436 controls) including those where MRI was performed from less then 12 hours to 1 month post-injury. The most common clinical outcome measure used in these studies was symptom burden using the Rivermead Post-Concussion Questionnaire. The most frequently studied brain connectivity MRI biomarkers were global functional connectivity, default-mode network, and fractional anisotropy. Despite the scant evidence and considerable methodological heterogeneity observed among studies, we conclude that brain connectivity MRI biomarkers obtained within one month of injury may be potentially useful in predicting outcome in mTBI. Further longitudinal studies are needed to evaluate the effect of mTBI on MRI-based brain connectivity biomarkers and examine how incorporation of these tests can inform the clinical care of individual mTBI patients.OBJECTIVE To evaluate facial nerve outcomes of various management strategies for facial schwannomas by assimilating individualized patient data from the literature to address controversies in management. DATA SOURCES PubMed-National Center for Biotechnology Information and Scopus databases. REVIEW METHODS A systematic review of the literature was performed for studies regarding facial schwannomas. Studies were included if they presented patient-level data, type of intervention, pre- and postintervention House-Brackmann (HB) grades, and tumor location by facial nerve segment. RESULTS Individualized data from 487 patients were collected from 31 studies. Eighty (16.4%) facial schwannomas were managed with observation, 25 (5.1%) with surgical decompression, 20 (4.1%) with stereotactic radiosurgery, 225 (46.2%) with total resection, and 137 (28.1%) with subtotal resection/stripping surgery. GA-017 LATS inhibitor Stripping surgery/subtotal resection with good preoperative facial nerve function maintained HB grade 1 or 2 in 96% of cases.