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The mean age in Group 2 was lower by a decade (Group 1 vs. Lipopolysaccharides cell line Group 2-59.45 vs 47.7 years).

Haemodialysis was the most common kidney replacement therapy in both groups and conservative management of ESKD was the second commonest available treatment option within Group 2. The disease burden was expected to grow >20% in 50% of Group 1 countries and 78% of Group 2 countries along with the parallel growth in haemodialysis and peritoneal dialysis.

20% in 50% of Group 1 countries and 78% of Group 2 countries along with the parallel growth in haemodialysis and peritoneal dialysis.Identifying novel classes of precatalysts for the oxygen evolution reaction (OER by water oxidation) with enhanced catalytic activity and stability is a key strategy to enable chemical energy conversion. The vast chemical space of intermetallic phases offers plenty of opportunities to discover OER electrocatalysts with improved performance. Herein we report intermetallic nickel germanide (NiGe) acting as a superior activity and durable Ni-based electro(pre)catalyst for OER. It is produced from a molecular bis(germylene)-Ni precursor. The ultra-small NiGe nanocrystals deposited on both nickel foam and fluorinated tin oxide (FTO) electrodes showed lower overpotentials and a durability of over three weeks (505 h) in comparison to the state-of-the-art Ni-, Co-, Fe-, and benchmark NiFe-based electrocatalysts under identical alkaline OER conditions. In contrast to other Ni-based intermetallic precatalysts under alkaline OER conditions, an unexpected electroconversion of NiGe into γ-NiIII OOH with intercalated OH- /CO32- transpired that served as a highly active structure as shown by various ex situ methods and quasi in situ Raman spectroscopy.

With the recent introduction of the MR-LINAC, an MR-scanner combined with a radiotherapy LINAC, MR-based motion estimation has become of increasing interest to (retrospectively) characterize tumor and organs-at-risk motion during radiotherapy. To this extent, we introduce low-rank MR-MOTUS, a framework to retrospectively reconstruct time-resolved nonrigid 3D+t motion fields from a single low-resolution reference image and prospectively undersampled k-space data acquired during motion.

Low-rank MR-MOTUS exploits spatiotemporal correlations in internal body motion with a low-rank motion model, and inverts a signal model that relates motion fields directly to a reference image and k-space data. The low-rank model reduces the degrees-of-freedom, memory consumption, and reconstruction times by assuming a factorization of space-time motion fields in spatial and temporal components.

Low-rank MR-MOTUS was employed to estimate motion in 2D/3D abdominothoracic scans and 3D head scans. Data were acquired using golring radiotherapy, and could form the basis for real-time MR-guided radiotherapy.Photodynamic and photothermal therapies (PDT, and PTT, respectively) are promising candidates for multimodal anticancer therapies (i.e., combinations of therapies), since their action is based on mechanisms that generally cannot be resisted by cancer cells, that is, generation of highly oxidizing oxygen species and high temperature, respectively. Herein, hybrid materials that combine octahedral molybdenum clusters as potential PDT agents and plasmonic spherical gold nanoparticles (AuNPs) as PTT agents are reported. Partial overlap of the photoemission spectrum of the cluster and the surface plasmon resonance band of the AuNPs facilitates energy transfer between the photoactive components, which resulted in synergetic enhancement of their photophysical properties. Specifically, by careful selection of the spacing between the cluster and the gold nanoparticle, a significant increase in luminescence and photosensitizing properties of the cluster was achieved in comparison with similar, but gold-free, particles. On the other hand, the cluster complex facilitated energy conversion to heat by gold particles and hence increased the heating rate under laser irradiation.A novel β-diketiminate stabilized gallium hydride, (Dipp L)Ga(Ad)H (where (Dipp L)=HC(MeCDippN)2 , Dipp=2,6-diisopropylphenyl and Ad=1-adamantyl), has been synthesized and shown to undergo insertion of carbon dioxide into the Ga-H bond under mild conditions. In this case, treatment of the resulting κ1 -formate complex with triethylsilane does not lead to regeneration of the hydride precursor. However, when combined with B(C6 F5 )3 , (Dipp L)Ga(Ad)H catalyses the reductive hydrosilylation of CO2 . Under stoichiometric conditions, the addition of one equivalent of B(C6 F5 )3 to (Dipp L)Ga(Ad)H leads to the formation of a 3-coordinate cationic gallane complex, partnered with a hydroborate anion, [(Dipp L)Ga(Ad)][HB(C6 F5 )3 ]. This complex rapidly hydrometallates carbon dioxide and catalyses the selective reduction of CO2 to the formaldehyde oxidation level at 60 °C in the presence of Et3 SiH (yielding H2 C(OSiEt3 )2 ). When catalysis is undertaken in the presence of excess B(C6 F5 )3 , appreciable enhancement of activity is observed, with a corresponding reduction in selectivity the product distribution includes H2 C(OSiEt3 )2 , CH4 and O(SiEt3 )2 . While this system represents proof-of-concept in CO2 hydrosilylation by a gallium hydride system, the TOF values obtained are relatively modest (max. 10 h-1 ). This is attributed to the strength of binding of the formatoborate anion to the gallium centre in the catalytic intermediate (Dipp L)Ga(Ad)OC(H)OB(C6 F5 )3 , and the correspondingly slow rate of the turnover-limiting hydrosilylation step. In turn, this strength of binding can be related to the relatively high Lewis acidity measured for the [(Dipp L)Ga(Ad)]+ cation (AN=69.8).

Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration.

PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross-sectional study. Three groups were defined <5 years (Group A); from 5 to <10 years (Group B); ≥10 years (Group C). Analysis with well-planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory-II [BDI-II] as dependent variable), to health-related QoL (39-item Parkinson's Disease Questionnaire [PDQ-39SI] as dependent variable) and to global QoL (European Health Interview Survey - Quality of Life Eight-Item Index [EUROHIS-QOL8] as dependent variable).

Six hundred and sixty-three PD patients (62.6 ± 8.