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The scheme divides the signing part into two phases, i.e., online and offline. In the absence of a message, the offline phase performs computationally intensive tasks, while lighter computations are executed in the online phase when there is a message. click here Security analyses and comparisons with the respective existing schemes are carried out to show the feasibility of the proposed scheme. The results obtained authenticate that the proposed scheme offers enhanced security with lower computational and communication costs.Bed resources are the platform in which most medical and health resources in the hospital play a role and carry the core functions of the health service system. How to improve the efficiency of the use of bed resources through scientific management measures and methods and ultimately achieve the optimization of overall health resources is the focus of hospital management teams. This paper analyzes the previous research models of knowledge related to queuing theory in medical services. From the perspective of the hospital and the patient, several indicators such as the average total number of people, the utilization rate of bed resources, the patient stop rate, and the patient average waiting time are defined to measure the performance of the triage queue calling model, which makes the patient queue more reasonable. According to the actual task requirements of a hospital, a Markov queuing strategy based on Markov service is proposed. A mathematical queuing model is constructed, and the process of solving steady-state probability based on Markov theory is analyzed. Through the comparative analysis of simulation experiments, the advantages and disadvantages of the service Markov queuing model and the applicable scope are obtained. Based on the theory of the queuing method, a queuing network model of bed resource allocation is established in principle. Experimental results show that the queuing strategy of bed resource allocation based on Markov optimization effectively improves resource utilization and patient satisfaction and can well meet the individual needs of different patients. It does not only provide specific optimization measures for the object of empirical research but also provides a reference for the development of hospital bed resource allocation in theory.Pancreatic metastases are rare, accounting for 2%-3% of pancreatic tumors. The pancreas represents an unusual metastatic site of synovial sarcoma (SS) outside the usual localizations (regional nodes, lung, bone, and liver). The diagnosis is evoked by the personnel medical history of SS and imaging then confirmed by histological examination of the guided pancreatic biopsy. Its therapeutic management is mainly surgical with extensive removal of the lesion. So far only four cases have been reported in the English literature. We reported the case of a male aged 30-year-old who was admitted to our Institute for a local recurrence of SS of the left thigh which was initially treated by surgical excision. The patient underwent a wide surgical excision followed by chemotherapy and radiotherapy. About 15 months later, he experienced a pancreatic metastasis of his SS. He had a caudal splenopancreatectomy with partial resection of the transverse colon followed by chemotherapy. This report highlights the diagnostic difficulties of this rare localization and therapeutic challenge.Thymoangiolipoma is a rare, slow-growing, benign thymic neoplasm that arises from the anterior mediastinum. A 61-year-old man with the chief complaint of right eye ptosis and high serum acetylcholine receptor antibody level is presented here. The spiral computed tomography of the chest revealed a hypodense mass in the anterior mediastinum. Microscopic examination showed admixture of adipose tissue, thymic tissue and blood vessels with the diagnosis of thymoangiolipoma. Thymoangiolipoma is a rare histologic variant of thymolipoma which can be associated with myasthenia gravis and must be considered as a differential diagnosis in anterior mediastinal mass with fat density in radiologic evaluation.In this report, we describe a 54-year-old male with cystic retroperitoneal sarcoma extending through the inguinal canal. Patient initially underwent inguinal hernia repair with mesh placement for suspected cord lipoma, after which he developed recurrent loculated retroperitoneal fluid collections refractory to multiple attempts at drain placement and laparotomy. Twenty-nine months after initial surgery, patient was referred to our institution on suspicion of malignancy. Pathology of resections taken during subsequent laparotomy showed foci of malignant cells interspersed throughout reactive proliferations. Follow-up immunohistochemistry confirmed high-grade sarcoma, likely atypical liposarcoma, but was unable to definitively establish subtype. Despite en bloc resection and gemcitabine/docetaxel chemotherapy, local progression continued, and patient was enrolled in clinical trials of doxorubicin with dual immune checkpoint blockade. This case suggests that sarcoma should be considered as a differential diagnosis of retroperitoneal or inguinal mass unresponsive to treatment; and highlights the difficulty of subtyping and managing cystic retroperitoneal sarcoma.

Coronavirus disease 2019 (COVID-19) is highly contagious and deadly and is associated with coagulopathy. Pentraxin-3(PTX3) participates in innate resistance to infections and plays a role in thrombogenesis.

The present study aimed to investigate the role of PTX3 in coagulopathy in patients with COVID-19.

A retrospective study, including thirty-nine COVID-19 patients, enrolled in Hunan, China, were performed. The patients were classified into the D-dimer_L (D-dimer <1mg/L) and D-dimer_H (D-dimer≥1mg/L) groups basing on the plasma D-dimer levels on admission. Serum PTX3 levels were detected by enzyme-linked immunosorbent assays and compared between those two groups, then receiver operating characteristic (ROC) curve analysis, correlation analysis, and linear regression models were performed to analyze the association between PTX3 and D-dimer.

Our results showed that serum PTX3 levels (median values, 10.21 vs. 3.36,

<0.001), computerized chest tomography (C.T.) scores (median values, 10.0 vs. 9.0,

<0.