Quinnstroud3581

Breast cancer is the most common cancer globally and among South African women. Women from socioeconomically disadvantaged South African communities more often present later and receive total mastectomy compared to those from more affluent communities who have more breast conserving surgery (which is less invasive but requires mandatory radiation treatment post-operatively). Standard chemotherapy and total mastectomy treatments are known to cause traumatizing side effects and emotional suffering among South African women; moreover, many women face limited communication with physicians and psychological support.

This article investigates the experiences of women seeking breast cancer treatment at the largest public hospital in South Africa.

We interviewed 50 Black women enrolled in the South African Breast Cancer Study to learn more about their health system experiences with detection, diagnosis, treatment, and follow-up care for breast cancer. Each interview was between 2-3 hours, addressing perceptionsand desires for treatment, structural barriers to intensive therapies, and the burden of invasive treatments are imperative next steps for delivering better breast cancer care in Soweto and other resource-constrained settings.Purpose. This study investigated the relationship between three selected personality traits and contextual factors with safety performance. Methods. This cross-sectional study was carried out among the operational staff of a gas refinery (n = 487) in Iran. Structural equation modeling was used to model the factors affecting safety performance based on personality traits and job and organizational-related factors including consideration of future safety consequence, safety locus of control and impulsiveness, safety climate, job insecurity and role overload, and mediator roles of safety knowledge and safety motivation. read more Results. Structural equation modeling results indicated that consideration of future safety consequence was directly correlated with safety performance. Impulsiveness and safety locus of control were indirectly associated with safety performance through the mediator role of safety knowledge and motivation. Furthermore, job insecurity and role overload were partially and directly correlated with safety performance. Moreover, safety climate had a significant relationship with safety performance. Conclusion. Consideration of future safety consequence is a valid personality trait for predicting safety performance. It can therefore be used as an indicator in the employee selection process. Moreover, improving employee safety performance necessitates increased safety knowledge and motivation as well as improved occupational characteristics and safety climate.

A sedentary lifestyle is associated with increased risk for cardiovascular disease (CVD). Smartwatches enable accurate daily activity monitoring for physical activity measurement and intervention. Few studies, however, have examined physical activity measures from smartwatches in relation to traditional risk factors associated with future risk for CVD.

To investigate the association of habitual physical activity measured by smartwatch with predicted CVD risk in adults.

We enrolled consenting FHS (Framingham Heart Study) participants in an ongoing eFHS (electronic Framingham Heart Study) at the time of their FHS research center examination. We provided participants with a smartwatch (Apple Watch Series 0) and instructed them to wear it daily, which measured their habitual physical activity as the average daily step count. We estimated the 10-year predicted risk of CVD using the American College of Cardiology/American Heart Association 2013 pooled cohort risk equation. We estimated the association betweenmeasured daily activity and incident CVD.

In this community-based sample of adults, higher daily physical activity measured by a study smartwatch was associated with lower predicted risk of CVD. Future research should examine the longitudinal association of prospectively measured daily activity and incident CVD.Aim The aim of this study is to prepare and characterize simvastatin-loaded nanoemulsions (SIM-LN) as well as evaluate their physicochemical properties and toxicity. Methodology & results The SIM-LN were prepared, their characteristics evaluated for 30 days, and after that, the SIM-LN toxicity was evaluated using Vero cell culture and the in vivo model of Caenorhabditis elegans. The prepared SIM-LN had an average droplet size of 139 ± 22 nm, with high encapsulation rate (>98.4%). The storage at room temperature proved to be the most optimal condition. Toxicity assays demonstrated no toxicity. Conclusion It was demonstrated that the surfactants used as emulsifiers optimized the properties without side effects, because no toxicity was measured in preliminary tests.Attachment orientations in adulthood can change over time, but the specific circumstances that directly affect change are not well understood. Bowlby proposed that those circumstances involve the assimilation of information that is incongruent with an individual's existing attachment orientation and underlying working models. In this study, 137 couples transitioning to parenthood were followed across the first 2 years of their firstborn child's life, with both partners providing data at five time-points. Only changes in attachment avoidance were examined in this study. Consistent with predictions, downward changes in avoidance were associated with relationship events that introduced information inconsistent with avoidant working models. For example, people who provided more support to their partners declined in avoidance across the transition period. We discuss these findings and new directions needed to better understand when and how attachment orientations change during major life transitions.

Quadrantectomy is a surgical procedure traditionally performed under general anaesthesia with intraoperative and postoperative opioid-based analgesia. The use of locoregional anaesthesia techniques in breast surgery has become widespread and allows excellent management of intraoperative and postoperative pain with reduced opioid consumption. We chose thoracic paravertebral block as regional anaesthesia technique in breast surgery to investigate the possibility of carrying out this surgery with the patient awake.

A prospective observational study on 50 patients was designed. The primary outcome for this study was the possibility to carry out the surgery with only the paravertebral block associated with mild sedation without general anaesthesia. Forty minutes before the start of the surgery, an ultrasound-guided thoracic paravertebral block was performed at two thoracic levels, and for each level, 7 mL of ropivacaine 0.7% was injected. Sedation was obtained with target-controlled infusion of propofol.

Forty-nine patients underwent the operation awake; in one case, we had to place an I-gel and perform general anaesthesia.