Quinnhealy5120
KDM4C plays a part in cytarabine opposition within severe myeloid leukemia by way of regulating the miR-328-3p/CCND2 axis via MALAT1.
Access to ultrasound image resolution: A new qualitative examine by 50 % n ., rural, Native communities throughout North america.
The COVID-19 pandemic has impacted on several aspects of human existence including primary care research activities in resource-limited settings. Opportunities exist for initiating multi-disciplinary collaborative research teams that may examine current controversial areas of the disease such as prevention, diagnosis and treatment; experiences of stakeholders like COVID-19 survivors and frontline health workers; and individuals and community experiences during lockdowns. Challenges associated with initiating new studies and/or sustaining old ones and publication of research outcomes may need to be curtailed through alternative strategies and support from stakeholders.[This corrects the article DOI 10.1089/acu.2020.1470.].A fatigue life prediction model with multiaxis load is proposed. The model introduces a new effective cyclic parameter, equivalent stress on the critical surface, to modify the Suntech model. The new damage parameters are not related to empirical constants, hence more applicable for practical application in engineering. The multiaxis fatigue test was carried out with high-strength aluminum alloy 7075-T651, and the multiaxis fatigue life prediction of the test piece was conducted with the finite element software. The experiment result shows that the model proposed is effective for predicting the fatigue life under multiaxis load.North Carolina-as a state in the racially segregated Southeast-offers a unique context to understand access to social services for Hispanic families and children. Theories of administrative burden posit that Hispanic families likely face high learning, compliance, and psychological costs. Hispanic families face challenges that compound these costs limited English language and literacy proficiency, complex household composition, and citizenship status of family members and other household members. With new survey results and qualitative data on social service administrators and front-line workers, we examine how these costs may affect access to programs for Hispanic families who reside in a state with a history of racial divisions that have shaped local policy implementation. Some workers noted transportation barriers and complex application processes as limiting access. While we expected to find that Hispanic families may be disadvantaged by decentralized service delivery in a manner that is similar to the experiences of African American families, workers instead note significant resources that help facilitate Hispanic families' access to programs. Workers view national anti-immigrant policies and rhetoric, rather than state and local policy rules or resource constraints, as limiting their capacity to serve Hispanic families.In medical practice, the concept of survival is reduced to a quantitative approach related to the patient's sameness. A philosophical refoundation of this concept, within the framework of the current contributions of the Covid-19 pandemic narratives and of Ricœurian hermeneutics, allows the development of survival-ipse. This is the hyperbolic force of refiguration of the living-dead human being. This excess of survival is, within the illness and the pandemic, the source of health and not its effect. The role of care is to constantly reactivate it.There are many kinds of brain abnormalities that cause changes in different parts of the brain. Alzheimer's disease is a chronic condition that degenerates the cells of the brain leading to memory asthenia. find more Cognitive mental troubles such as forgetfulness and confusion are one of the most important features of Alzheimer's patients. In the literature, several image processing techniques, as well as machine learning strategies, were introduced for the diagnosis of the disease. find more This study is aimed at recognizing the presence of Alzheimer's disease based on the magnetic resonance imaging of the brain. We adopted a deep learning methodology for the discrimination between Alzheimer's patients and healthy patients from 2D anatomical slices collected using magnetic resonance imaging. Most of the previous researches were based on the implementation of a 3D convolutional neural network, whereas we incorporated the usage of 2D slices as input to the convolutional neural network. The data set of this research was obtained from the OASIS website. We trained the convolutional neural network structure using the 2D slices to exhibit the deep network weightings that we named as the Alzheimer Network (AlzNet). The accuracy of our enhanced network was 99.30%. This work investigated the effects of many parameters on AlzNet, such as the number of layers, number of filters, and dropout rate. The results were interesting after using many performance metrics for evaluating the proposed AlzNet.To evaluate the efficacy and safety of intravitreal conbercept (IVC) for diabetic retinopathy (DR) compared with intravitreal triamcinolone acetonide (IVTA). PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP database, and Wanfang database were searched from their earliest records to January 2020. We included randomized controlled trials (RCTs) evaluating the efficacy and safety of conbercept in DR patients compared with ITVA. Outcomes included the mean changes from the baseline in best corrected visual acuity (BCVA) score, central macular thickness (CMT), quality of life (QoL) over time, and the incidence of adverse events (AEs). A total of 19 RCTs involving 1,811 eyes were included in this meta-analysis. IVC might improve BCVA (WMD = 0.10, 95% CI (0.07, 0.12), P less then 0.001) and reduce CMT (WMD = -102.5, 95% CI (-148.48, -56.53), P less then 0.001) compared to IVTA. link2 The incidence of AEs in patients receiving IVC was significantly lower than those receiving IVTA (RR = 0.29, 95% CI (0.21, 0.40), P less then 0.001). Patients with IVC treatments acquired better self-care, mobility, social, and mental scores compared with IVTA (P less then 0.001). link2 Current evidence shows that IVC has better effects and safety than IVTA in treating DR, and it can significantly enhance the QoL of patients with DR.Cancer incidence rate has been increasing drastically in recent years. One of the many cancer treatment methods is chemotherapy. Traditional medicine, in the form of complementary and alternative therapy, is actively used to treat cancer, and many herbs and active ingredients of such therapies are being intensely studied to integrate them into modern medicine. Ginseng is traditionally used as a nourishing tonic and for treating various diseases in Asian countries. The therapeutic potential of ginseng in modern medicine has been studied extensively; the main bioactive component of ginseng is ginsenosides, which have gathered attention, particularly for their prospects in the treatment of fatal diseases such as cancer. Ginsenosides displayed their anticancer and antimetastatic properties not only via restricting cancer cell proliferation, viability, invasion, and migration but also by promoting apoptosis, cell cycle arrest, and autophagy in several cancers, such as breast, brain, liver, gastric, and lung cancer. Additionally, ginsenosides can work synergistically with already existing cancer therapies. Thus, ginsenosides may be used alone or in combination with other pharmaceutical agents in new therapeutic strategies for cancer. To date however, there is little systematic summary available for the anticancer effects and therapeutic potential of ginsenosides. Therefore, we have reviewed and discussed all available literature in order to facilitate further research of ginsenosides in this manuscript.Alismatis rhizoma (AR), which is the dried rhizome of Alisma orientale (Sam.) Juz. find more (Alismataceae), is an important component of many famous Chinese formulas for hypoglycemic. This study aimed to evaluate the insulin resistance (IR) alleviating effects of AR triterpenes (ART) and ART component compatibility (ARTC, the mixture of 16-oxo-alisol A, 16-oxo-alisol A 23-acetate, 16-oxo-alisol A 24-acetate, alisol C, alisol C 23-acetate, alisol L, alisol A, alisol A 23-acetate, alisol A 24-acetate, alisol L 23-acetate, alisol B, alisol B 23-acetate, 11-deoxy-alisol B and 11-deoxy-alisol B 23-acetate) in high-fat diet-induced IR mice and plamitate-treated IR C2C12 cells, respectively. A dose of 200 mg/kg of ART was orally administered to IR mice, and different doses (25, 50, and 100 μg/ml) of ARTC groups were treated to IR C2C12 cells. IPGTT, IPITT, body weight, Hb1AC, FFA, TNF-α, MCP-1, and IR-associated gene expression (p-AMPK, p-IRS-1, PI3K, p-AKT, p-JNK, and GLUT4) were measured in IR mice. Glucose uptake, TNF-α, MCP-1, and IR-associated gene expression were also measured in IR C2C12 cells. Results showed that ART alleviated high-fat diet-induced IR in the skeletal muscle of mice, and this finding was further validated by ARTC. This study demonstrated that ART presented a notable IR alleviating effect by regulating IR-associated gene expression, and triterpenes were the material basis for the IR alleviating activity of AR.
Phytochemical medicines containing tanshinol and ligustrazine are commonly used in the treatment of stable angina in China, but their clinical effectiveness and risk have not been adequately assessed. In this paper, we conducted a systematic review and meta-analysis to evaluate the clinical efficacy.
Relevant randomized controlled trials (RCTs) of phytochemical medicines containing tanshinol and ligustrazine in the treatment of stable angina were searched in electronic databases. The search date was up to March 31, 2020, and the languages of the RCTs were limited to English and Chinese.
A total of 28 studies, including 2518 patients, were included in the meta-analysis. It was shown that the adjunctive therapy of phytochemical medicines containing tanshinol and ligustrazine was better than the conventional therapies in the improvement of stable angina according to the clinical efficacy in symptoms (
= 2518, RR = 1.24, 95% CI 1.20 to 1.29,
< 0.01) and clinical efficacy in electrocardiography (
= 1766, RR = 1.29, 95% CI 1.19 to 1.40,
< 0.01).
The meta-analysis supported the use of phytochemical medicines containing tanshinol and ligustrazine in the treatment of stable angina. However, quality of the evidence for this finding was low due to a high risk of bias in the included studies. Therefore, well-designed RCTs are still needed to further evaluate the efficacy.
The meta-analysis supported the use of phytochemical medicines containing tanshinol and ligustrazine in the treatment of stable angina. link2 However, quality of the evidence for this finding was low due to a high risk of bias in the included studies. Therefore, well-designed RCTs are still needed to further evaluate the efficacy.
As a traditional Chinese medicine,
Herba (ASH) is used to treat various liver diseases. The purpose of this study was to explore the mechanisms of ASH for treating chronic hepatitis B (CHB) using a network pharmacological method.
Bioactive ingredients and related targets of ASH were obtained from Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Gene names of targets were extracted from UniProt database. link3 Differentially expressed genes (DEGs) of CHB were obtained from microarray dataset GSE83148. The intersect genes between DEGs and target genes were annotated using clusterProfiler package. The STRING database was used to obtain a network of protein-protein interactions. Cytoscape 3.7.2 was used to construct the "ingredient-gene-pathway" (IGP) network. link3 Molecular docking studies were performed using Autodock vina.
A total of 13 active components were extracted from TCMSP database. link3 Fifteen intersect genes were obtained between 183 target genes and 403 DEGs of GSE83148. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis results showed that ASH against CHB mainly involved in toll-like receptor signaling pathway, cellular senescence, hepatitis B, and chemokine signaling pathway.
