Putnamrios8420

Its targeting accuracy was compared with magnetic resonance imaging (MRI)-guided targeting based on co-registration between CBCT and corresponding sequential magnetic resonance scans, which offer greater soft tissue contrast compared with CT alone. Evaluation of our platform's BLI-guided targeting accuracy was performed by quantifying in vivo changes in bioluminescence signal after treatment as well as staining of ex vivo tissues with γH2AX, Ki67, TUNEL, CD31 and CD11b to assess SBRT treatment effects. Using our platform, we found that BLI-guided SBRT enabled more accurate delivery of X rays to the tumor resulting in greater cancer cell DNA damage and proliferation inhibition compared with MRI-guided SBRT. Furthermore, BLI-guided SBRT allowed higher animal throughput and was more cost effective to use in the preclinical setting than MRI-guided SBRT. Taken together, our preclinical platform could be employed in translational research of SBRT of pancreatic cancer.The indigenous population of the United Arab Emirates (UAE) has a unique demographic and cultural history. Its tradition of endogamy and consanguinity is expected to produce genetic homogeneity and partitioning of gene pools while population movements and intercontinental trade are likely to have contributed to genetic diversity. Emiratis and neighboring populations of the Middle East have been underrepresented in the population genetics literature with few studies covering the broader genetic history of the Arabian Peninsula. Here, we genotyped 1,198 individuals from the seven Emirates using 1.7 million markers and by employing haplotype-based algorithms and admixture analyses, we reveal the fine-scale genetic structure of the Emirati population. Shared ancestry and gene flow with neighboring populations display their unique geographic position while increased intra- versus inter-Emirati kinship and sharing of uniparental haplogroups, reflect the endogamous and consanguineous cultural traditions of the Emirates and their tribes.

-The traditional role of the insurance medical director is evolving. RGA surveyed insurance medical directors to provide an overview of their roles, skill sets, future trends, and their increasing and changing contributions to the insurance industry in recent years and throughout the current pandemic.

-RGA conducted a first-of-a-kind global survey of medical directors in the insurance industry. The online survey took place from April to June 2021 and had seven key sections medical experience and qualifications, roles and responsibilities, underwriting and claims capabilities, adapting to change, disease and product trends in insurance, challenges, and future opportunities. Globally, 124 insurance medical directors from 84 companies participated in the survey.

-Respondents are an experienced group of medical directors, with 88% active in the medical profession for 10 years or more. Eighty-seven respondents (70%) dedicate the majority of their time to providing technical medical expertise. Forty-eight perdirector in the life and health insurance industry is promising.

-The future of the medical director role will require more strategic responsibilities, greater product development expertise, and stronger data and analytics skills to support insurer needs. It will be important for insurance medical directors to engage in conversations with their employers to discuss their current and emerging roles.

-The future of the medical director role will require more strategic responsibilities, greater product development expertise, and stronger data and analytics skills to support insurer needs. It will be important for insurance medical directors to engage in conversations with their employers to discuss their current and emerging roles.

Omega-3 fatty acids modulate inflammatory processes and are considered beneficial for sport populations highlighting a need to practically assess omega-3 intake. Food frequency questionnaires (FFQ) are inexpensive, non-invasive, tools aimed to evaluate nutrient intakes like omega-3 fatty acids. A tailored, brief FFQ for estimating omega-3 intake has been previously reported in healthy adults to be associated with erythrocyte omega-3 fatty acid levels, a biomarker for omega-3 tissue status and indicative of intake. However, the association between a brief omega-3 FFQ with respective erythrocyte levels, particularly Omega-3 Index has yet to be explored in a sport population.

Examine the association between omega-3 intake using a brief FFQ and Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and EPA+DHA) in collegiate women soccer players.

Cross-sectional study.

University sport team.

Thirty-one NCAA Division I collegiate women soccer players.

The brief omega-3 FFQ assessed dietary omega-3 intake DHA, EPA. OmegaQuant blood test measured erythrocyte omega-3 fatty acids (EPA, DHA) and Omega-3 Index (EPA+DHA) levels.

Brief FFQ intake of EPA, DHA, and EPA+DHA were positively correlated with erythrocyte EPA (r = 0.48, p = 0.007), DHA (r = 0.73, p < 0.001), and Omega-3 Index (r = 0.73, p < 0.001).

In a sample of collegiate women soccer players, the brief omega-3 FFQ is correlated with erythrocyte omega-3 fatty acid levels and may be a practical tool for health practitioners in assessing omega-3 intake within this collegiate sport population.

In a sample of collegiate women soccer players, the brief omega-3 FFQ is correlated with erythrocyte omega-3 fatty acid levels and may be a practical tool for health practitioners in assessing omega-3 intake within this collegiate sport population.Environments that make it easier for people to incorporate physical activity into their daily life may help to reduce high rates of cardiometabolic conditions. Local zoning codes are a policy and planning tool to create more walkable and bikeable environments. This study evaluated relationships between active living-oriented zoning code environments and cardiometabolic conditions (body mass index, hyperlipidemia, hypertension). The study used county identifiers to link electronic health record and other administrative data for a sample of patients utilizing primary care services between 2012 and 2016 with county-aggregated zoning code data and built environment data. The analytic sample included 7,441,991 patients living in 292 counties in 44 states. Latent class analysis was used to summarize municipal- and unincorporated county-level data on seven zoning provisions (e.g., sidewalks, trails, street connectivity, mixed land use), resulting in classes that differed in strength of the zoning provisions. Based on the probability of class membership, counties were categorized as one of four classes. Linear and logistic regression models estimated cross-sectional associations with each cardiometabolic condition. Galunisertib Models were fit separately for youth (aged 5-19), adults (aged 20-59), and older adults (aged 60+). Little evidence was found that body mass index in youth, adults, or older adults or the odds of hyperlipidemia or hypertension in adults or older adults differed according to the strength of active living-oriented zoning. More research is needed to identify the health impacts of zoning codes and whether alterations to these codes would improve population health over the long term.

Little is known about how the combination of pain severity and duration impact quadriceps function and self-reported function in patients with AKP.

To examine how severity (low [≤3 out of 10] vs. high [>3 out of 10]) and/or duration (short [<2 years] vs. long [>2 years]) of AKP affect quadriceps function and self-reported function.

Cross-sectional study.

Laboratory.

Sixty patients with AKP (mean = pain severity 4 out of 10 in Numeric Pain Rating Scale; pain duration 38 months) and 48 healthy controls. Patients with AKP were categorised into three subdivisions based on pain 1) severity (low vs. high); 2) duration (short vs. long); and 3) severity and duration (low/short vs. low/long vs. high/short vs. high/long).

Quadriceps maximal (maximal voluntary isometric contraction) and explosive (rate of torque development) strength, activation (central activation ratio), and endurance (average peak torque), and self-reported function (Lower Extremity Functional Scale) were compared.

Compared witP.Audit and feedback is commonly used as a method of both monitoring and attempting to improve the quality of healthcare. No review has examined the literature on systems-level audit and feedback strategies to improve the quality of oncology care. This scoping review examines the number, care focus (technical, nontechnical, or both) and methodological quality of published intervention studies which have used systems-level audit and feedback intended to improve the quality of care delivered in oncology treatment centers. Medline, Embase, PsycINFO, and the Cochrane database were searched, from inception to March 2021, for intervention studies which examined the effectiveness of systems-level audit and feedback in improving care for cancer patients. Studies which met the Effective Practice and Organization of Care (EPOC) minimum design criteria were then assessed using the EPOC risk of bias tool. Study characteristics and outcomes were extracted for those meeting methodological criteria. A narrative approach was used to synthesize the results. A total of 32 intervention studies met the inclusion criteria, of which 53% focused on technical aspects of care, 31% focused on nontechnical and 16% focused on both. Four of the included 32 studies met the EPOC minimum design criteria (13%). Most studies had a before-after study design (75%; n = 24) and methodological quality of the final four studies was moderate. Audit and feedback studies involving oncology treatment centers have primarily focused on technical care aspects. The low number and moderate methodological quality of the studies make it difficult to draw clear inferences about the effectiveness of systems-level audit and feedback. Furthermore, high-quality audit and feedback interventions are required across technical and nontechnical aspects of care to quantify the effectiveness of strategies for improving cancer care and ensure healthcare resources are being optimized.

Several tools exist to reduce rectal temperature (TREC) quickly for patients experiencing exertional heatstroke (EHS). Stationary tubs (TUB) effectively treat EHS but are bulky and impractical in some situations. More portable cold-water immersion (CWI) techniques, like tarp-assisted cooling with oscillation (TACO), are gaining popularity due to their benefits (e.g., less water needed, portability). The Polar Life Pod® (PLP) may be another portable way to reduce TREC, but little research has examined its effectiveness.

We questioned whether the PLP and TUB reduced TREC at "acceptable" or "ideal" rates, whether TREC cooling rates differed by method, and how subjects felt before, during, and after cooling.

Randomized, crossover study.

Laboratory.

Thirteen individuals (8 men, 5 women; age21±2y; mass73.99±11.24kg; height176.2±11.1cm).

Participants exercised in the heat until TREC was 39.5°C. They immersed themselves in TUB (567.8±7.6L; 15.0±0.1°C) or PLP (202.7±23.8L; 3.2±0.6°C) until TREC was 38°C. Thermal sensation and environmental symptom questionnaire (ESQ) responses were recorded before, during, and after exercise and cooling.