Pughsilverman8151

This research represents a paradigm shift for wearable applications by redefining garment fit to fully topographical conformation to the wearer through advanced materials and structures design.Increased esophagectomy procedures over the past four decades have correlated with the rise in incidence of esophageal adenocarcinoma. Despite advances in technology and procedural expertise, esophagectomy remains a high-risk surgical procedure. Higher volume facilities have more experience with esophagectomy and would be expected to have a lower incidence of surgical complications and attendant morbidity and mortality. By analyzing information from a nationwide United States hospital database, we sought to find out if there is a significant difference between facilities stratified by case volume, with regards to 30-day readmission after esophagectomy. The findings of this study indicated that even with a large applied differential, early readmissions did not differ significantly between high- and low-volume centers. Also, analyzed and discussed were any associated demographic and comorbidity factors as they relate to early readmissions after esophagectomy for esophageal adenocarcinoma across the country. This is the first study to specifically address these variables. Copyright © 2020 Kwabena Oware Adu-Gyamfi et al.Background Transcatheter aortic valve replacement (TAVR) has been validated for the treatment of severe symptomatic aortic stenosis in patients at high and intermediate surgical risk. Recently, TAVR has been proposed as an alternative to medical therapy in inoperable patients with severe native aortic valve regurgitation (NAVR). This multicenter international registry sought to evaluate safety and efficacy of TAVR with the self-expandable ACURATE neo valve in a cohort of patients with NAVR. Methods A total of 24 patients with severe NAVR treated by TAVR between September 2016 and October 2018 in 13 European centers were included. Clinical, procedural and follow up data were inserted in a dedicated database. Outcomes were codified according to Valve Academic Research Consortium-2 criteria. Results Mean age was 79.4 years, 58.4% were female. Mean EuroSCORE II and STS score were 5% and 3.9%, respectively. Device success was 87.5%. Moderate paravalvular leak (PVL) was found in two (8.3%) of patients, both with a perimeter oversizing index less then 10%. Implantation of a second device was necessary in three cases (12.5%), one for severe PVL and two for device displacement. New pacemaker implantation rate was 21.1%. At 30 days, stroke and all-cause mortality rates were 0% and 4.1%, respectively. Conclusions This multicenter study suggests good feasibility and early safety of transfemoral TAVR with the self-expandable ACURATE neo device in patients with severe NAVR refused for surgery. Rates of moderate PVL, new pacemaker implantation and need for a second valve were higher than those reported for TAVR in aortic stenosis. © 2020 The Authors.Population aging in middle-income countries, including China, has resulted in strong economic incentives to increase the retirement age. These economic incentives should be weighed up against the effects of later retirement on physical and mental health and wellbeing. We aimed to determine the causal effect of retirement on perceived stress, an important measure of mental well-being. We used data from the China Health and Nutrition Survey in 2015 and adopted a non-parametric regression discontinuity design (RDD) to measure the causal effect of retirement on stress. Stress was assessed using the Perceived Stress Scale (PSS)-14. On average, the effect of retirement on stress was close to the null value and insignificant. In subgroup analyses, we found that retirement reduces stress in men but raises stress in women. Though these gender-specific effects were not statistically significant, their magnitudes were large. Thus, the average null result in the entire population appears to hide opposite gender-specific effects. More research is needed to confirm this finding in studies with larger sample sizes and understand the gender-specific pathways leading from retirement to stress. © 2019 The Authors.Platinum-resistant, recurrent, high grade epithelial ovarian carcinoma remains challenging to treat. Chemotherapy produces limited responses with modest survival benefits in the treatment of recurrent disease. In this context, targeted therapies may improve upon conventional therapies. PI3K/AKT pathway alterations are frequently found in several cancer types, including ovarian cancer, and thus AKT inhibition is a rational targeted therapy. Here we report the results of an abbreviated trial of AKT inhibitor MK-2206 in platinum resistant high grade serous ovarian, fallopian tube, and primary peritoneal cancer with PTEN loss. © 2020 The Authors.Presented manuscript described data analysis on near infrared spectroscopy used as adopted and portable technology for cocoa farmers in Aceh Province, Indonesia. The near infrared spectroscopy (NIRS) assisted farmers in post-harvest handling especially for cocoa quality evaluation. This technology was used to determine moisture content (MC) and fat content (FC) of intact cocoa bean samples rapidly and simultaneously. Near infrared spectra data were acquired as absorbance spectrum in wavelength range from 1000 to 2500 nm with co-added of 32 scans for a total of 72 intact bulk cocoa bean samples. Spectra data can be used to predict MC and FC of intact cocoa beans by establishing prediction models and validate with actual MC and FC measured by means of standard laboratory procedures. Prediction performances were evaluated using several statistical indicators coefficient correlation (r), coefficient of determination (R2), root mean square error (RMSE) and residual predictive deviation (RPD) index. CX-5461 concentration Near infrared spectra data can be enhanced using spectra pre-treatment methods to improve prediction performances. Moreover, prediction models can be developed using principal component regression (PCR), partial least squares regression (PLSR) and other regression approaches. Ideal prediction models should have r and R2 above 0.75, RPD index above 2.0 and RMSE lower than its standard deviation (SD). Dataset were available as raw MS Excel format and The Unscrambler files as *.unsb extension. © 2020 The Author(s).