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5 years (78 ± 43.5 months), 18 patients had completion thyroidectomy and twelve were diagnosed with contralateral cancer (n=8) or lymph node metastases (n=4). In patients with recurrence followed for >2 years, there was a rise in Tg in three cases, Tg was stable in two cases, and in one TgAb decreased from 1534 to 276IU/mL despite metastatic lymph-node. Basal Tg and Tg dynamics did not predict disease recurrence. CONCLUSIONS Serum thyroglobulin used independently is of limited value for predicting or detecting disease recurrence following thyroid lobectomy. Other potential roles of Tg, such as detecting distant metastases following lobectomy, should be further studied. © Endocrine Society 2020. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.Preterm birth remains the major cause of perinatal mortality and morbidity worldwide, affecting up to 12% of pregnancies and accounting for approximately 75% of neonatal deaths. However, the mechanisms and causes that underlie it are still largely unknown. One of the major cause of preterm birth is infection or inflammation within the maternal-fetal interphase. Our lab has previously shown that a uterine specific deletion of Nodal results in mutant females delivering two days prior to term demonstrating an important role for this factor in the maintenance of pregnancy. Here we have addressed the function of Nodal in the uterus during pregnancy. We demonstrate that Nodal heterozygous mice have an increase in basal levels of proinflammatory cytokines IL-1β, IL-6, IL-12p, TNF-α, and IFN-γ as well as an increase in the number of macrophages in response to the inflammatory agent, LPS. Using Bone Marrow Derived Macrophages, we demonstrated that pretreatment with recombinant Nodal reduces proinflammatory gene expression when these cells are challenged with LPS. Our results demonstrate that Nodal is required to maintain the uterine environment in an anti-inflammatory state by preventing proinflammatory cytokine expression. © The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction.OBJECTIVES Previous studies have shown the association of exposure to noise with cardiovascular diseases such as hypertension, however, it is not well known whether the exposure has any effect on metabolic syndrome (MetS). This study aimed to quantify and clarify the association between noise exposure and the prevalence of MetS. METHODS This cross-sectional study was conducted in 2017 among 518 workers in a thermal power plant industry. According to types of work and 8-h equivalent A-weighted sound pressure level (8-h LAeq), the participants were divided into the following groups office workers and line-production workers exposed to 102 cm), there was a significant difference in the ≥100 dBA group (12 [19.7%]) compared with office group (21 [9.8%]). Obtained results indicated only the significant difference in the prevalence of MetS in ≥100 versus less then 85 dBA groups (10 [16.4%] versus 6 [6.1%]). The unadjusted and adjusted odds ratios and 95% confidence intervals of MetS in ≥100 versus less then 85 dBA groups were estimated 3.01 (1.03, 8.75) and 3.24 (1.01, 10.42), respectively. CONCLUSIONS This study indicated the significant association between noise exposure and MetS in line-production workers. However, more studies are needed to confirm our results. © The Author(s) 2020. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.OBJECTIVES Daily driving of diesel-powered tractors has been linked to increased lung cancer risk in farmers, yet few studies have quantified exposure levels to diesel exhaust during tractor driving or during other farm activities. We expanded an earlier task-based descriptive investigation of factors associated with real-time exposure levels to black carbon (BC, a surrogate of diesel exhaust) in Iowa farmers by increasing the sample size, collecting repeated measurements, and applying statistical models adapted to continuous measurements. METHODS The expanded study added 43 days of sampling, for a total of 63 sample days conducted in 2015 and 2016 on 31 Iowa farmers. Real-time, continuous monitoring (30-s intervals) of personal BC concentrations was performed using a MicroAeth AE51 microaethelometer affixed with a micro-cyclone. A field researcher recorded information on tasks, fuel type, farmer location, and proximity to burning biomass. We evaluated the influence of these variables on log-transformed BC coproximity to burning biomass. These results could support the development of exposure models applicable to investigations of health effects in farmers associated with exposure to diesel engine exhaust. Published by Oxford University Press on behalf of The British Occupational Hygiene Society 2020.BACKGROUND Disease-specific guidelines are not aligned with multimorbidity care complexity. Meeting all guideline-recommended care for multimorbid patients has been estimated but not demonstrated across multiple guidelines. OBJECTIVE Measure guideline-concordant care for patients with multimorbidity; assess in what types of care and by whom (clinician or patient) deviation from guidelines occurs and evaluate whether patient characteristics are associated with concordance. METHODS A retrospective cohort study of care received over 1 year, conducted across 11 primary care clinics within the context of multimorbidity-focused care management program. Patients were aged 45+ years with more than two common chronic conditions and were sampled based on either being new (≤6 months) or veteran to the program (≥1 year). MEASURES Three guideline concordance measures were calculated for each patient out of 44 potential guideline-recommended care processes for nine chronic conditions overall score; referral score (proportion of guideline-recommended care referred) and patient-only score (proportion of referred care completed by patients). Guideline concordance was stratified by care type. RESULTS 4386 care processes evaluated among 204 patients, mean age = 72.3 years (standard deviation = 9.7). Overall, 79.2% of care was guideline concordant, 87.6% was referred according to guidelines and patients followed 91.4% of referred care. Guideline-concordant care varied across care types. Age, morbidity burden and whether patients were new or veteran to the program were associated with guideline concordance. CONCLUSIONS Patients with multimorbidity do not receive ~20% of guideline recommendations, mostly due to clinicians not referring care. Determining the types of care for which the greatest deviation from guidelines exists can inform the tailoring of care for multimorbidity patients. © The Author(s) 2020. Published by Oxford University Press. MEK phosphorylation All rights reserved.For permissions, please e-mail journals.permissions@oup.com.