Povlsenblevins2003

Premature ejaculation (PE) is the most common male sexual dysfunction. The brain disturbances that cause this disorder remain poorly understood. This study aimed to investigate how the morphology of cortical and subcortical brain structures differed in PE, how these morphologic differences were associated with severity measures of PE, such as intravaginal ejaculatory latency time (IELT), and how these cortical and subcortical structures were causally connected through mediation analysis. Anatomical MRI scans were acquired from 39 male participants, 23 with PE (28.78 ± 4.32 years), and 16 without PE (27.88 ± 3.65 years). We used a subcortical analysis package within FSL to perform subcortical shape segmentation and statistical analysis. The PE group was compared with the normal control (NC) group in the shapes of 15 subcortical structures with general linear models [p less then 0.05, family-wise error (FWE)-corrected]. We analyzed the cortical complexity revealed by the gyrification index using the Computational Anatomy Toolbox (CAT12). Vertex-wise shape analyses revealed outward shape deformations (expansions) in the left hippocampus and bilateral thalamus. Gyrification index analyses revealed that the right orbital frontal cortex and the right nucleus accumbens had greater complexity in PE patients. The shape deformations were positively correlated with the IELTs in the NC group, while this relationship was interrupted in the PE group. PE is associated with outward deformations of the subcortical surfaces and more complexity of the cortical structures. These morphological differences may be the basis of the brain functional alterations underlying PE.Despite widely reported gender differences in both brain structure and brain function, very few studies have examined the relationship between the structural differences and the functional differences between genders. Here, different imaging measures including both structural [i.e., gray matter volume (GMV)] and functional [i.e., regional homogeneity (ReHo) and functional connectivity (FC)] measures were employed to detect the gender differences in the human brain based on univariate and multivariate approaches with a sample of 290 healthy adults (155 females). The univariate analyses revealed that gender differences were detected in both structural (i.e., GMV) and functional (ReHo or FC) imaging measures, mainly manifested as greater values in females than in males in regions of the frontal, parietal, occipital lobes and cerebellum. Importantly, there was little overlap between the differences detected in GMV and those detected in ReHo and FC, and their differences between genders were not correlated with each other. The multivariate pattern analyses revealed that each of these measures had discriminative power to successfully distinguish between genders (classification accuracy 94.3%, 90.73%, and 83.89% for GMV, ReHo, and FC, respectively) and their combination further improved the classification performance (96.6%). Our results suggest that gender differences are encoded in both brain structure and brain function, but in different manners. The finding of different and complementary information contained in structural and functional differences between genders highlights the complex relationship between brain structure and function, which may underlie the complex nature of gender differences in behavior.Typical anticipatory postural adjustments (APAs) in forward gait or step initiation tasks to prepare for possible disturbances caused by prime voluntary movements and to accelerate the body forward have been previously reported. However, it is not clear how wide the variations in step directions are differentiated and controlled in non-forward step initiation tasks during the APA phase. The main goal of this study is to explain the directional control mechanisms by investigating the APA of step initiation tasks in forward, diagonal, lateral, and posterior directions. The center of pressure (COP) trajectories and related muscle (soleus, tibialis anterior, and gluteus medius of both lower limbs) activities during the APA of step initiation tasks in nine different directions were analyzed in six healthy young males. Posterior shifts of COP during APA decreased as the direction became more lateral (0° to 90°). Tanespimycin nmr For posterior step initiations, COP moved anteriorly from the initial position to accelerate the center of mass of the whole body (COM) backward. Lateral shifts of COP toward the stepping foot during APA decreased as the stepping direction became more lateral (from 0° to 45° and from 180° to 113°) while it plateaued to about zero in the direction from 45° to 113°. Both anteroposterior and lateral displacements of COP in APA were nonlinearly modulated to each direction, but they were linearly related to the anteroposterior and mediolateral component of the velocities of COM at the take-off of the stance foot. Thus, the scaling of APA, reflected in the anteroposterior and lateral displacements of COP and the temporal sequence of selected muscle activities, was based on the anteroposterior and mediolateral components of the take-off velocity of COM that ultimately controls the direction of steps.Recent studies suggest that development of absence epilepsy and comorbid depression might be prevented by increased maternal care of the offspring, in which tactile stimulation induced by licking/grooming and non-nutritive contact seem to be crucial. In this study, we aimed to evaluate the effect of neonatal tactile stimulations (NTS) on absence epilepsy and depression-like behaviors in adulthood. Wistar Albino Glaxo from Rijswijk (WAG/Rij) rat pups with a genetic predisposition to absence epilepsy were divided into tactile stimulation (TS) group, deep touch pressure (DTP) group, maternal separation (MS) group or control group. Between postnatal day 3 and 21, manipulations (TS, DTP, and MS) were carried out for 15 min and three times a day. Animals were submitted to locomotor activity, sucrose consumption test (SCT) and forced swimming test (FST) at five months of age. At the age of six months, the electroencephalogram (EEG) recordings were conducted in order to quantify the spike-wave discharges (SWDs), which is the hallmark of absence epilepsy.