Pollardcarlson2243

Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 189 000 people in Italy, with more than 25 000 deaths. Several predictive factors of mortality have been identified; however, none has been validated in patients presenting with mild disease. Methods Patients with a diagnosis of interstitial pneumonia caused by SARS-CoV-2, presenting with mild symptoms, and requiring hospitalization in a non-intensive care unit with known discharge status were prospectively collected and retrospectively analysed. Demographical, clinical and biochemical parameters were recorded, as need for non-invasive mechanical ventilation and admission in intensive care unit. Univariate and multivariate logistic regression analyses were used to identify independent predictors of death. Results Between 28 February and 10 April 2020, 229 consecutive patients were included in the study cohort; the majority were males with a mean age of 60 years. 54% of patients had at least one comorbidity, with hypertension being the most commonly represented, followed by diabetes mellitus. 196 patients were discharged after a mean of 9 days, while 14.4% died during hospitalization because of respiratory failure. Age higher than 75 years, low platelet count (750 ng/mL) were independent predictors of death. Comorbidities were not independently associated with in-hospital mortality. Conclusions In-hospital mortality of patients with COVID-19 presenting with mild symptoms is high and is associated with older age, platelet count and ferritin levels. Identifying early predictors of outcome can be useful in the clinical practice to better stratify and manage patients with COVID-19.Professor Folke Sjöqvist, MD, PhD, passed away on March 30, 2020 at the age of 86 years in Stockholm, Sweden. He was a pioneer in clinical pharmacology in Sweden and dedicated to the development of the discipline world-wide. He is survived by his wife Margareta and four children with families. Folke graduated from Medical School in 1959 and defended his PhD thesis on ganglionic cholinergic transmission in the autonomic nervous system in 1962 at Karolinska Institutet under the mentorship of Professor Bo Holmstedt. Soon thereafter, he joined as post-doctoral fellow the legendary Bernard B.When populations colonize new habitats, they are likely to experience novel environmental conditions, and as a consequence may experience strong selection. While selection and the resulting evolutionary responses may have important implications for establishment success in colonizing populations, few studies have estimated selection in such scenarios. Here we examined evidence of selection in recently established plant populations in two prairie restorations in close proximity ( less then 15 km apart) using two approaches 1) we tested for evidence of past selection on a suite of traits in two Chamaecrista fasciculata populations by comparing the restored populations to each other and their shared source population in common gardens to quantify evolutionary responses and 2) we measured selection in the field. BMS-387032 ic50 We found evidence of past selection on flowering time, specific leaf area, and root nodule production in one of the populations, but detected contemporary selection on only one trait (plant height). Our findings demonstrate that while selection can occur in colonizing populations, resulting in significant trait differences between restored populations in less than 6 generations, evolutionary responses differ across even nearby populations sown with the same source population. Because contemporary measures of selection differed from evolutionary responses to past selection, our findings also suggest that selection likely differs over the early stages of succession that characterize young prairies.Unsupervised home exercise is a major component of physical therapy (PT). This study proposes an inexpensive, inertial measurement unit-based wearable device to capture kinematic data to facilitate exercise. However, conveying and interpreting kinematic data to non-experts poses a challenge due to the complexity and background knowledge required that most patients lack. Objectives The objectives of this study were to identify key user interface and user experience features that would likely improve device adoption and assess participant receptiveness toward the device. Methods Fifty participants were recruited to perform nine upper extremity exercises while wearing the device. Prior to exercise, participants completed an orientation of the device, which included examples of software graphics with exercise data. Surveys that measured receptiveness toward the device, software graphics, and ergonomics were given before and after exercise. Results Participants were highly receptive to the device with 90% of the participants likely to use the device during PT. Participants understood how the simple kinematic data could be used to aid exercise, but the data could be difficult to comprehend with more complex movements. Devices should incorporate wireless sensors and emphasize ease of wear. Conclusion Device-guided home physical rehabilitation can allow for individualized treatment protocols and improve exercise self-efficacy through kinematic analysis. Future studies should implement clinical testing to evaluate the impact a wearable device can have on rehabilitation outcomes.Background There is a recognized need to improve how scholarly data are managed and accessed. The scientific community has proposed the findable, accessible, interoperable, and reusable (FAIR) data principles to address this issue. Objective The objective of this case study was to develop a system for improving the FAIRness of Healthcare Cost and Utilization Project's State Emergency Department Databases (HCUP's SEDD) within the context of data catalog availability. Materials and methods A search tool, EDCat (Emergency Department Catalog), was designed to improve the "FAIRness" of electronic health databases and tested on datasets from HCUP-SEDD. ElasticSearch was used as a database for EDCat's search engine. Datasets were curated and defined. Searchable data dictionary-related elements and unified medical language system (UMLS) concepts were included in the curated metadata. Functionality to standardize search terms using UMLS concepts was added to the user interface. Results The EDCat system improved the overall FAIRness of HCUP-SEDD by improving the findability of individual datasets and increasing the efficacy of searches for specific data elements and data types.