Plougdickinson8076

The particles with PDMAEMA shell showed the highest release of DOX at pH = 7.4 whereas PMAA shells displayed the least cumulative release. Inversely, the lowest cumulative release at pH = 1.2 was shown by PDMAEMA-coated carriers. Moreover, particles with spherical morphology had better drug release than cauliflower-like ones originated from smart nature of carriers. Graphene is composed of a two-dimensional (2D) layer of carbon atoms arranged in a honeycomb lattice configuration. In this paper, we adopted a green synthetic method of producing reduced graphene oxide using glucose as a reducing and stabilizing agent. We also investigated the fabrication of electrospun nanofibers of glucose-reduced graphene oxide (GRGO) (0-1.0 wt%) reinforced with polyvinyl alcohol (PVA) as (PG) scaffolds, and chemically crosslinked with acidic glutaraldehyde (GA) in acetone medium to mimic the extracellular matrix (ECM) for skin tissue engineering applications. These PG scaffolds were evaluated for morphology, mechanical strength, surface wettability, thermal properties, hemocompatibility, and biocompatibility. Field emission-scanning electron microscopy (FE-SEM) revealed an increase in the thickness of nanofibers in PG scaffolds with an increase in the concentration of GRGO. X-ray diffraction and attenuated total reflectance-infrared and Raman spectra showed the GRGO was incorporated in the PVA nanofibrous matrix. As the concentration of GRGO was increased in PG scaffolds, tensile strengths and elongations at break decreased, whereas thermal properties increased. The biological activities of PG scaffolds were evaluated using in vitro hemolysis, using CCD-986Sk (a human skin fibroblast cell line) viability and proliferation assays, and by live/dead cell imaging. Results showed GRGO inclusion in PVA nanofibers caused a slight hydrophilic to hydrophobic shift. PG scaffolds did not cause hemolysis of red blood cells even at a GRGO loading of 1.0 wt%, and PG-1.0 scaffold (with a GRGO loading of 1.0 wt%) exhibited excellent compatibility with fibroblasts and significantly increased metabolic activity after culture for 21 days as compared with PG-0 controls. DAPI staining and live/dead imaging assays showed that all PG scaffolds increased fibroblast proliferation and viability, indicating the potential for skin tissue engineering applications. AIMS To examine the potential impact of regular cannabis use on cardiovascular and subjective responses to acute stress. DESIGN We used a quasi-experimental design in which subjective states and cardiovascular measures were obtained during rest and in response to acute stress challenges in a sample of regular cannabis users and non-users. PARTICIPANTS Seventy-nine adults (forty-five cannabis users and thirty-four non-users). MEASUREMENTS We measured subjective states (positive affect, state stress, state anxiety, cannabis craving) and cardiovascular indicators (blood pressure, heart rate, mean arterial pressure) during baseline rest and in response to public speaking, mental arithmetic, and cold-pressor challenges. Regular cannabis use was established via self-report and was confirmed with a positive urine drug test. FINDINGS Regular cannabis use was associated with blunted positive affect (F = 5.67, p = .002), state stress (F = 6.05, p = .002), and state anxiety (F = 6.48, p  less then  .001) in response to acute stress challenges. There was no evidence of an association between cannabis use and cardiovascular responses (Fs ≤ 1.54; Ps ≥ 0.21). Contrary to expectations, cannabis craving decreased in response to stress challenges (F = 8.44, p  less then  .001). CONCLUSION Chronic cannabis use is associated with blunted positive and negative (stress, anxiety) affective responses to acute stress, indicating emotional dysregulation in this population. BACKGROUND Collaborations between nursing schools and teaching hospitals are important for achieving the goals of clinical nursing education. While previous work showed that nursing students benefit from academic-practice partnerships, it is unclear how these collaborations help nursing students. OBJECTIVE To identify the role of academic-practice partnerships from the perspective of nursing students. Two hypothetical models based on system theory were proposed that utilized input-transformation-output processes. The input, transformation, and outputs were the "academic-practice partnership", "interaction between nurses and nursing students", and "professional self-concept and organizational socialization of nursing students", respectively. DESIGN This study used a cross-sectional research design. SETTING This study was conducted at a nursing school in Korea. PARTICIPANTS The participants included 243 fourth-year nursing students who were about to graduate. METHODS A questionnaire was used to collect data in preceptors to teach nursing students. STUDY DESIGN This was a retrospective study of prospectively collected data. OBJECTIVE This study aimed to characterize the factors associated with the development of myelopathy at each cervical level based on spinal cord evoked potentials (SCEPs) and radiological parameters in patients with cervical ossification of the posterior longitudinal ligament (OPLL). SUMMARY OF BACKGROUND DATA Static factors, dynamic factors, and combinations of these factors are associated with the development of OPLL-related myelopathy. PATIENTS AND METHODS Fifty patients with OPLL were enrolled in this study. They underwent kinematic computed tomography myelography (CTM), MRI, and X-ray examinations, and the levels responsible for their myelopathy were determined by intraoperatively assessing SCEPs. C2-7 lordosis, C2-7 range of motion (ROM), and segmental ROM were assessed on the midsagittal view during flexion and extension and in the neutral position using the Cobb method, and the cross-sectional area of the spinal cord (CSA) was measured on the axial view in each neck position using kinematic CTM. The cervical levels were classified into responsible (Group R) and non-responsible (Group N) levels. RESULTS The responsible level was C3-4, C4-5, C5-6, and C6-7 in 18, 23, 18, and 4 patients, respectively. In the multivariate analysis, the CSA was significantly smaller in Group R than in Group N at all responsible levels, but the dynamic change in the CSA was only associated with myelopathy at the C3-4 and C4-5 levels. ITD-1 datasheet CONCLUSION Myelopathy at the C3-4 level was more strongly associated with dynamic factors and a shorter disease duration, than myelopathy at the C5-6 level. This study provides useful information for assessing the pathophysiology of OPLL-related cervical myelopathy and managing the condition.