Phelpsholdt7116

Furthermore, the NporMOF(Fe) modified electrode shows excellent selectivity toward the detection of NO and H2O2 in the presence of other physiologically important analytes. This method shows excellent biosensing performance, implying the universal applicability of MOFs-based artificial nanozymes for biosensors and the potential application for third generation biosensors.In the last few years, there has been emerging interest in developing treatments against human diseases using natural bioactive content. Here, the powder of the edible mushroom Pleurotus eryngii var. eryngii was mixed with the normal diet of mice bearing C26 colon carcinoma. Interestingly, it was evidenced by a significant increase in the survival rate of C26 tumor-bearing mice accompanied by a significant increase in Hsp90 and Hsp27 protein levels in the tumors. These data were paralleled by a decrease in Hsp60 levels. The mushroom introduced in the diet induced the inhibition of the transcription of the pro-inflammatory cytokines IL-6 and IL-1 exerting an anti-inflammatory action. The effects of the mushroom were mediated by the activation of c-Jun NH2-terminal kinases as a result of metabolic stress induced by the micronutrients introduced in the diet. In the tumors of C26 bearing mice fed with Pleurotus eryngii there was also a decreased expression of the mitotic regulator survivin and the anti-apoptotic factor Bcl-xL as well as an increase in the expression levels of Atg7, a protein that drives autophagy. In our hypothesis the interplay of these molecules favored the survival of the mice fed with the mushroom. These data are promising for the introduction of Pleurotus eryngii as a dietary supplement or as an adjuvant in anti-cancer therapy.High-level single and multireference ab initio calculations show that the Be4 cluster behaves as a very efficient Lewis acid when interacting with conventional Lewis bases such as ammonia, water or hydrogen fluoride, to the point that the corresponding acid-base interaction triggers a sequential dissociation of all the bonds of the Lewis base. Notably, this behavior is already found for the simplest beryllium cluster, the Be2 dimer. However, whereas for Be2 the first dissociation process involves a low activation barrier which is above the reactants, for Be4 all the bond dissociation processes involve barriers below the entrance channel leading to a cascade of successive exothermic processes, which end up spontaneously in a global minimum in which the bonding patterns of both the base and the Lewis acid are completely destroyed. Indeed, the global minimum, in all cases, is stabilized by three-center Be-H-Be bonds and covalent interactions between the Be atoms and the basic center of the base, which replace the initial metallic bond stabilizing the Be4 cluster. As a consequence, in the global minimum the basic atoms (N, O and F) behave as hyper-coordinated centers. Also importantly, the Be4 cluster and its complexes present RHF-UHF instabilities (not reported before for Be4), which require the use of multireference methods to correctly describe them.The selectivity of product formation is strongly correlated with the nature of the catalyst active centers. Therefore, the selective synthesis of active sites with certain structure is a big challenge in modern catalysis. Here synthetic procedures are adopted for the formation of 1% Rh/TiO2 catalysts with different properties. It is shown that the nature of the precursor used for catalyst preparation is important, and that the use of a solution of rhodium acetate instead of rhodium nitrate leads to the selective formation of butenes during 1,3-butadiene hydrogenation. The use of parahydrogen in the reaction results in the enhancement of NMR signals via parahydrogen-induced polarization (PHIP) for all synthesized catalysts, and this signal enhancement increases with increasing catalyst calcination temperature. This effect is explained by the decoration of rhodium nanoparticles with titania which restricts hydrogen mobility on the surface, leading to the highest reported to date selectivity toward the pairwise hydrogen addition route of 7% for supported metal catalysts.In this Letter, the surface hydrophilicity of the quantum dot (QD) emitting layer (EML) was modified via a ligand exchange to prevent QD EML damage upon hole transport layer (HTL) deposition for all-solution-processed inverted QD-light-emitting diodes (QLEDs). The conventional hydrophobic oleic acid ligand (OA-QDs) was partially replaced with a hydrophilic 6-mercaptohexanol (OH-QDs) through a one-pot ligand exchange. Owing to this replacement, the contact angle of a water droplet on the OH-QD films was reduced to 71.7° from 89.5° on the OA-QD films, indicating the conversion to hydrophilic hydroxyl ligands. The OH-QD EML maintained its integrity without any noticeable damage, even after HTL deposition, enabling all-solution processing for inverted QLEDs with well-organized multilayers. Inverted QLEDs with the OH-QD EMLs were compared with those with OA-QD EMLs; the maximum current efficiency of the device with the OH-QD EML significantly improved to 39.0 cd A-1 from 5.3 cd A-1, and the peak external quantum efficiency improved to 9.3% from 1.2%, which is a seven-fold increase over the OA-QD device. This approach is believed to be effective for forming solid QD films with resistance to chlorobenzene, a representative HTL solvent, and consequently contributes to high-efficiency all-solution-processed inverted QLEDs.DNA molecules are hard to catch using traditional optical trapping due to the nanometer width of their chains. Here we experimentally demonstrate a label-free optical trapping of a single micrometer λ-DNA in solution by the aid of plasmonic gold nanoparticles (GNPs), where a double-laser trap induces strong optical interparticle forces for the tweezer. We examine such sub-resolved interparticle forces by tracking the GNP dynamics in solution. Moreover, surface-enhanced Raman scattering signals of trapped λ-DNA have also been measured simultaneously in the same setup. In comparison with prior works, ours benefit from the excitation in a dynamic configuration without fabrication. This technique opens a new avenue for all-optical manipulation of biomolecules, as well as ultra-sensitive bio-medical sensing applications.Thin-film lithium-niobate-on-insulator (LNOI) is a very attractive platform for optical interconnect and nonlinear optics. It is essential to enable lithium niobate photonic integrated circuits with low power consumption. Zamaporvint ic50 Here we present an edge-coupling Mach-Zehnder modulator on the platform with low fiber-chip coupling loss of 0.5 dB/facet, half-wave voltage Vπ of 2.36 V, electro-optic (EO) bandwidth of 60 GHz and an efficient thermal-optic phase shifter with half-wave power of 6.24 mW. In addition, we experimentally demonstrate single-lane 200 Gbit/s data transmission utilizing a discrete multi-tone signal. The LNOI modulator demonstrated here shows great potential in energy-efficient large-capacity optical interconnects.Pump-probe microscopy is an emerging nonlinear imaging technique based on high repetition rate lasers and fast intensity modulation. Here, we present new methods for pump-probe microscopy that keep the beam intensity constant and instead modulate the inter-pulse time delay or the relative polarization. These techniques can improve image quality for samples that have poor heat dissipation or long-lived radiative states and can selectively address nonlinear interactions in the sample. We experimentally demonstrate this approach and point out the advantages over conventional intensity modulation.Digital holographic microscopy (DHM) is a future three-dimensional (3D) microscopy due to its high-resolution and high-precision 3D images. Thus, it is getting attention in bioinformatics, semiconductor defect detection, etc. However, some limitations still exist. Especially, high-speed holographic imaging requires high-power lasers, which are difficult to image on highly absorbent or light-sensitive samples. To overcome these issues, we propose a new, to the best of our knowledge, digital hologram recovery algorithm called angular spectrum matching (ASM), which achieves hologram imitation to recover holograms in digital holography at low light intensities. The hologram used for the background phase comparison is recorded without objects; thus, no power limitation is required. The ASM utilizes this background hologram to recover dark holograms. We present experimental results showing improved DHM numerical reconstructions and recovered holograms under extremely low light conditions.Metasurfaces able to concentrate light at various wavelengths are promising for enhancing nonlinear interactions. In this Letter, we experimentally demonstrate infrared second-harmonic generation (SHG) by a multi-resonant nanostructure. A 100 GaAs layer embedded in a metal-insulator-metal waveguide is shown to support various localized resonances. One resonance enhances the nonlinear polarization due to the transverse magnetic (TM)-polarized pump wavelength near 3.2µm, while another is set near the TE-polarized generated wavelength (1.6µm). link2 The measured SHG efficiency is higher than 10-9W-1 for pump wavelengths ranging from 2.9 to 3.3µm, which agrees with theoretical computations. This is typically 4 orders of magnitude higher than the equivalent GaAs membrane.Optical masquerades are a low-cost camouflage strategy that avoids the hidden objects to be recognized despite being detected. Here, we demonstrate an optical holography-based masquerade that could encode the camouflaged object ("bomb") into another uncorrelated phase object ("dog") by using transmissive dielectric metasurfaces with the total efficiency as high as 78% at visible wavelengths. The phase modulation in the encoded "dog" is realized by changing the inplane orientation of nanostructures. link3 Illuminated by the circularly polarized light, the experimental hologram fabricated by using electron-beam lithography exhibits only the "dog" pattern when observing the surface of sample. To recover the hidden "bomb," one can observe the holographic image reconstructed at the Fresnel region, which works at the broadband spectrum from 540 nm to 680 nm. Such a technique might find potential applications in information security and military affairs.We investigate (both theoretically and experimentally) a method for fundamental mode spectral filtering in single-mode optical fibers using the resonant mode coupling effect. We demonstrate the possibility of controlling the spectral bandwidth of the fundamental mode suppression band through appropriate choice of fiber parameters and fiber bending. The developed technique can be very useful for the design of fiber-based spectral filters (i.e., active fibers with suppression of laser emission at undesirable wavelengths, suppression of stimulated Raman scattering).The fundamental mode confinement loss (CL) of anti-resonant hollow-core fiber (ARF) is efficiently predicted by a classification task of machine learning. The structure-parameter vector is utilized to define the sample space of ARFs. The CL of labeled samples at 1550 nm is numerically calculated via the finite element method (FEM). The magnitude of CL is obtained by a classification task via a decision tree and k-nearest neighbors algorithms with the training and test sets generated by 290700 and 32300 labeled samples. The test accuracy, confusion matrices, and the receiver operating characteristic curves have shown that our proposed method is effective for predicting the magnitude of CL with a short computation runtime compared to FEM simulation. The feasibility of predicting other performance parameters by the extension of our method, as well as its ability to generalize outside the tested sample space, is also discussed. It is likely that the proposed sample definition and the use of a classification approach can be adopted for design application beyond efficient prediction of ARF CL and inspire artificial intelligence and data-driven-based research of photonic structures.