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In prepubertal rats injected with vigabatrin, puberty onset was delayed. Abat mRNA, Kiss1 mRNA and Gnrh mRNA levels were significantly reduced, but Rfrp-3 mRNA level increased in the hypothalamus. Vigabatrin reduced the concentrations of GABA-T, luteinizing hormone (LH) and progesterone (P4), and the ovarian index. Lactation performance was reduced in adult rats with vigabatrin treatment. Four hours after vigabatrin injection, the concentrations of GABA-T and LH were significantly reduced in adult and 25 d rats, but follicle-stimulating hormone (FSH) increased in 25 d rats. In conclusion, GABA-T affects the reproductive function of female rats by regulating the levels of Gnrh, Kiss1 and Rfrp-3 in the hypothalamus as well as the concentrations of LH and P4.Gold nanoparticles (AuNPs) were produced using stainless steel as a solid reductant to assist the synthesis of metal NPs, using HAuCl4 as a precursor. This method is very easy, quick, and cost-effective, allowing the synthesis of highly stable NPs without additional capping agents. However, the reaction mechanism is still under debate. In order to contribute to the investigation of the synthesis of AuNPs using stainless steel, different experimental conditions were tested. Cl- concentration, pH of the precursor solution, as well as stainless steel composition were systematically changed. The syntheses were performed recording the open circuit potential to potentiometrically explore the electrochemical properties of the system, under operando conditions. Spectroscopic and morphological characterizations were carried out along with potentiometric monitoring, aiming at correlating the synthesis parameters with the AuNPs characteristics. As a result, an overview of the process features, and of its most reasonable mechanism were obtained.Myelin is critical for the proper function of the nervous system and one of the most complex cell-cell interactions of the body. Myelination allows for the rapid conduction of action potentials along axonal fibers and provides physical and trophic support to neurons. Myelin contains a high content of lipids, and the formation of the myelin sheath requires high levels of fatty acid and lipid synthesis, together with uptake of extracellular fatty acids. Recent studies have further advanced our understanding of the metabolism and functions of myelin fatty acids and lipids. In this review, we present an overview of the basic biology of myelin lipids and recent insights on the regulation of fatty acid metabolism and functions in myelinating cells. In addition, this review may serve to provide a foundation for future research characterizing the role of fatty acids and lipids in myelin biology and metabolic disorders affecting the central and peripheral nervous system.In the context of growing the adoption of advanced sensors and systems for active vehicle safety and driver assistance, an increasingly important issue is the security of the information exchanged between the different sub-systems of the vehicle. Random number generation is crucial in modern encryption and security applications as it is a critical task from the point of view of the robustness of the security chain. Random numbers are in fact used to generate the encryption keys to be used for ciphers. click here Consequently, any weakness in the key generation process can potentially leak information that can be used to breach even the strongest cipher. This paper presents the architecture of a high performance Random Number Generator (RNG) IP-core, in particular a Cryptographically Secure Pseudo-Random Number Generator (CSPRNG) IP-core, a digital hardware accelerator for random numbers generation which can be employed for cryptographically secure applications. The specifications used to develop the proposed project were derived from dedicated literature and standards. Subsequently, specific architecture optimizations were studied to achieve better timing performance and very high throughput values. The IP-core has been validated thanks to the official NIST Statistical Test Suite, in order to evaluate the degree of randomness of the numbers generated in output. Finally the CSPRNG IP-core has been characterized on relevant Field Programmable Gate Array (FPGA) and ASIC standard-cell technologies.Introduction Domestic violence (DV) during pregnancy is associated with poor health outcomes for both the mother and newborn, and sometimes death. In a low-income country like Nepal, women have few options to leave abusive situations. Therefore, there is a need for interventions to improve their safety. The aim of our study was to explore the use of safety measures before and after an educational intervention among women who have reported DV during pregnancy. Materials and methods Of 1010 pregnant women screened consecutively for DV using the Abuse Assessment Screen (AAS) during routine antenatal care, 181 women reported domestic violence. All 1010 participating pregnant women were taught 15 safety measures using a locally developed flipchart. We obtained contact with 80 of the 181 eligible women postpartum, of whom 62 completed the follow-up assessment. We explored and described the use of safety measures at baseline and follow-up, using a standardized instrument called the Safety Behavior Checklist. Results At follow-up, less than half of the women (n = 30, or 48.3%) reported any form of DV. Of the women who reported DV at follow-up, significantly more reported the experience of both violence and fear at baseline (21.9%, p = 0.01) compared with the women who did not report DV at follow-up (3.3%, p = 0.01). Women reporting DV at baseline and follow-up used more safety measures at baseline (56) and follow-up (80) compared with women reporting DV at baseline only (36 and 46). Women reporting DV at baseline and follow-up used more safety measures for the first time at follow-up, 57 new measures compared with the 28 new measures used by women reporting DV at baseline only. Conclusions The use of a flipchart teaching session on safety measures within antenatal care may increase the number of safety measures women use to protect themselves during pregnancy and decrease the risks of adverse health effects of DV.