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sis in patients who have undergone prior orbital decompression.

Two cases are presented to highlight the indications, surgical technique, and early clinical outcomes associated with proximal humerus corrective osteotomy using a 90° cannulated blade plate in adolescent patients.

A complex deformity of the proximal humerus in the adolescent patient poses an uncommon yet debilitating clinical condition that is challenging to manage. We report a unique method for surgical correction and fixation using an infant hip osteotomy 90° blade plate that restores native shoulder anatomy, improves function, and has led to early clinical success.

A complex deformity of the proximal humerus in the adolescent patient poses an uncommon yet debilitating clinical condition that is challenging to manage. We report a unique method for surgical correction and fixation using an infant hip osteotomy 90° blade plate that restores native shoulder anatomy, improves function, and has led to early clinical success.

To report combined central arterial and venous occlusions secondary to bilateral leukemic interfascicular optic nerve infiltration in a 56-year-old man. This was the sole presentation of a relapse in T/Myeloid mixed-phenotype acute leukemia after 5 months of remission.

Case report with clinical photography.

A 56-year-old man reported to be in complete remission of T/Myeloid mixed-phenotype acute leukemia (MPAL) presented with sudden painless loss of vision in his left eye. Fundoscopy showed unilateral severe optic disc swelling with characteristic findings of a central retinal vein occlusion (CRVO), namely, intra- and preretinal haemorrhages and cotton-wool spots, as well as the features of a central retinal artery occlusion (CRAO) resulting in a pale, edematous retina and a characteristic cherry-red spot. Bicuculline inhibitor Blood, cerebrospinal fluid evaluation and bone marrow analysis were performed in combination with medical imaging. No evidence of leukemic relapse was found. An optic nerve biopsy was indicated, due to decompensation of the contralateral eye, and ultimately confirmed leukemic infiltration.

Regardless of no hematological and non-specific imaging findings, optic nerve biopsy may be crucial for clinical decision making in a patient with acute complete vision loss and a history of leukemia.

Regardless of no hematological and non-specific imaging findings, optic nerve biopsy may be crucial for clinical decision making in a patient with acute complete vision loss and a history of leukemia.

To describe a case of post-operative retinal toxicity following the use of mitomycin C during a routine trabeculectomy.

Case report of a single patient who underwent complete ophthalmic examination and multimodal imaging, including color fundus photos, optical coherence tomography (OCT), fundus autofluorescence (FAF), and fluorescein angiography (FA). The study was declared exempt by the Institutional Review Board of Northwestern University. This research followed the tenets of the Declaration of Helsinki.

The patient developed profound vision loss and retinal damage during the post-operative course. Posterior segment findings include loss of vascular perfusion, diffuse loss of the outer, then inner, retinal layers, and subsequent total retinal detachment.

While MMC is commonly used in glaucoma filtering surgeries, reports of post-operative posterior segment toxicity are rare. The etiology of post-operative toxicity in this case is probable inadvertent intraocular injection of MMC.

While MMC is commonly used in glaucoma filtering surgeries, reports of post-operative posterior segment toxicity are rare. The etiology of post-operative toxicity in this case is probable inadvertent intraocular injection of MMC.

To report a case of exudative perifoveal vascular anomalous complex treated with a 532 nm subthreshold micropulse laser unresponsive to intravitreal injections.

A case report.

A 65-year-old woman presented with blurred vision in left eye for 1 month. An isolated perifoveal aneurysm surrounded by retinal hemorrhages and hard exudates was revealed in fundus examination and optical coherent tomography showed a round lesion with a hyperreflective wall, subretinal fluid, and an intraretinal cyst. She was diagnosed with exudative perifoveal vascular anomalous complex and received 4 intravitreal injections. However, her best-corrected visual acuity decreased and an aneurysmal lesion with macular edema persisted for approximately 6 months. We applied 3 sessions of 532 nm subthreshold micropulse laser therapy around the aneurysm because the intravitreal injection treatment was ineffective. Since the last session, macular edema was disappeared and the involuted lesion remained substantially stable without recurrence and her best-corrected visual acuity improved without visual field defect.

To our knowledge, this is the first report of a successful subthreshold micropulse laser treatment for an exudative perifoveal vascular anomalous complex lesion and it could be a safe and effective method for the patient unresponsive to intravitreal injections.

To our knowledge, this is the first report of a successful subthreshold micropulse laser treatment for an exudative perifoveal vascular anomalous complex lesion and it could be a safe and effective method for the patient unresponsive to intravitreal injections.

To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography (OCT) imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled-related protein).

Case report and review of the relevant literature.

Single patient followed by the Weill Cornell Medicine Department of Ophthalmology Retina and Glaucoma Services.

A patient with a novel homozygous mutation in the MFRP gene (c.472C>T) presented with nanophthalmos, optic disc drusen, foveal hypoplasia, and extensive peripheral retinoschisis, which was revealed to be multilevel retinoschisis on ultra-wide field OCT. Unlike other reported cases, the findings associated with this novel mutation did not include foveoschisis nor clinically obvious retinitis pigmentosa. The patient underwent prophylactic peripheral laser iridotomy in both eyes.

Here we present a patient with nanophthalmos, optic disc drusen, and foveal hypoplasia associated with extensive peripheral retinoschisis imaged by ultra-widefield OCT, but not foveal retinoschisis or prominent retinitis pigmentosa.