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73 ± 0.51 D, with 86% within ±1.00 D of target. Uncorrected distance visual acuity (UDVA) was 20/20 or better in 74% of eyes at twelve months. No patients lost ≥2 lines of corrected distance visual acuity (CDVA) at twelve months. The mean angle of error was -0.9 ± 10.2° at three months and -1.6 ± 12.8° at twelve months. One patient required bilateral lens rotation, four patients underwent secondary enhancement with LASIK/PRK, and seven patients underwent postoperative limbal relaxing incisions.
This initial single-site experience finds Toric ICL implantation for myopic astigmatism to be safe and effective. Patients can achieve markedly improved UDVA in a single surgery with stable vision over time and minimal adverse subjective symptoms.
This initial single-site experience finds Toric ICL implantation for myopic astigmatism to be safe and effective. Patients can achieve markedly improved UDVA in a single surgery with stable vision over time and minimal adverse subjective symptoms.
In this study, we aimed to report on the early results of intrascleral intraocular lens (IOL) fixation using a hook-shaped haptic IOL (hsh-IOL).
We enrolled 27 consecutive eyes of 27 patients (mean age, 74±11.4 years) who underwent intrascleral IOL fixation with an hsh-IOL and were followed-up for 3 months postoperatively. The reasons for surgery included insufficient capsular support, including IOL dislocation, aphakia, or dislocated crystalline lens. The haptic of the hsh-IOL was externalized from the eye using forceps, and the hook was buried in the scleral tunnel. We investigated the preoperative and 3-month postoperative corrected visual acuity (VA), intraocular pressure (IOP), corneal endothelial cell density, refractive prediction error, postoperative intraocular astigmatism, surgically induced astigmatism, and intraoperative and postoperative complications.
The mean postoperative corrected VA (logMAR, 0.083±0.18) was significantly better than the mean preoperative value (0.42±0.60, p=0.0007). The 3-month postoperative mean absolute prediction error was 1.00±0.96 D. The mean IOL-induced astigmatism was 0.95±0.70 D. Further, the mean postoperative corneal endothelial cell count (2036±644 cells/mm
) was significantly lower than the preoperative value (2316±527 cells/mm
) (p=0.009). No patient had a 1-month postoperative IOP <5 mmHg or >25 mmHg. There were no intraoperative or vision-threatening complications, such as retinal detachment, endophthalmitis, or IOL dislocation, due to postoperative haptics misalignment.
Intrascleral IOL fixation using hsh-IOL is an effective option for eyes with insufficient capsular support.
Intrascleral IOL fixation using hsh-IOL is an effective option for eyes with insufficient capsular support.
We previously investigated the efficacy and safety of adding 0.1% brimonidine (Brim) or 0.5% timolol (Tim) to prostaglandin analogue (PGA) monotherapy to treat patients with normal-tension glaucoma (NTG) with intraocular pressure (IOP) of ≤16 mmHg. Herein, we describe an additional post-hoc stratifying analysis of the possible differences in the effect of IOP-lowering and pulse rate (PR) after adjunctive Brim or Tim to PGA.
This study included 128 subjects. Patients with NTG treated with PGA were stratified based on their baseline IOP. The changes in IOP from baseline and the effect of patient factors on IOP changes were investigated. Patients were stratified by age for investigation of their PR and blood pressure (BP). The change and the effect of patient factors on PR and BP were investigated.
After stratification analysis, in 52 eyes treated with Brim and 61 eyes with Tim with baseline IOP 12 ≤ IOP ≤ 16 mmHg, both eye drops lowered IOP significantly (P < 0.0001), and the IOP-lowering efficacy of Bcantly in the Tim group even after age stratification. PR should be considered when selecting β-blockers for glaucoma treatment.
To compare the effective lens position (ELP), anterior chamber depth (ACD) changes, and visual outcomes in patients with and without pseudoexfoliation syndrome (PEX) after cataract surgery.
Prospective, randomized, fellow-eye controlled clinical case series.
This prospective comparative case series enrolled 56 eyes of 56 consecutive patients with (n = 28) or without PEX (n = 28) and clinically significant cataract who underwent standard phacoemulsification and were implanted with single-piece acrylic posterior chamber intraocular lenses (IOLs). The primary outcome parameters were the ACD referring to the distance between the corneal anterior surface and the lens anterior surface, which is an indicator of the postoperative axial position of the IOL (the so-called ELP) and distance corrected visual acuity (DCVA).
Before surgery, the ACD was 2.54 ± 0.42 mm in the PEX group and 2.53 ± 0.38 mm in the control group (p = 0.941). Postoperatively, the ACD was 4.29 ± 0.71 mm in the PEX group and 4.33 ± 0.72 mm in the normal group, respectively (p = 0.533). There was no significant difference in ACD changes between groups (PEX group 1.75 ± 0.74 mm, control group 1.81 ± 0.61 mm, p = 0.806) and DCVA pre- (p = 0.469) and postoperatively (PEX group 0.11 ± 0.13 logMAR, control group 0.09 ± 0.17 logMAR, p = 0.245) between groups.
Preoperative and postoperative ACD, as an indicator of ELP, between PEX eyes and healthy eyes after cataract surgery showed no significant difference. Phacoemulsification induced similar changes in eyes with PEX compared to healthy eyes.
Preoperative and postoperative ACD, as an indicator of ELP, between PEX eyes and healthy eyes after cataract surgery showed no significant difference. Phacoemulsification induced similar changes in eyes with PEX compared to healthy eyes.The target bodies of C-complex asteroid sample return missions are carbonaceous chondrite-like near-Earth asteroids (NEAs), chosen for the abundance and scientific importance of their organic compounds and "hydrous" (including hydroxylated) minerals, such as serpentine-group phyllosilicates. Science objectives include returning samples of pristine carbonaceous regolith from asteroids for study of the nature, history, and distribution of its constituent minerals, organic material, and other volatiles. Heating after the natural aqueous alteration that formed the abundant phyllosilicates in CM and similar carbonaceous chondrites dehydroxylated them and altered or decomposed other volumetrically minor constituents (e.g., carbonates, sulfides, organic molecules; Tonui et al. 2003, 2014). We propose a peak-temperature thermometer based on dehydroxylation as measured by analytical totals from electron probe microanalysis (EPMA) of matrices in a number of heated and aqueously altered (but not further heated) CM chondrites. Some CM lithologies in Maribo and Sutter's Mill do not exhibit the matrix dehydroxylation expected for surface temperatures expected from insolation of meteoroids with their known orbital perihelia. This suggests that insolated-heated meteoroid surfaces were lost by ablation during passage through Earth's atmosphere, and that insolation-heated material is more likely to be encountered among returned asteroid regolith samples than in meteorites. More generally, several published lines of evidence suggest that episodic heating of some CM material, most likely by impacts, continued intermittently and locally up to billions of years after assembly and early heating of ancestral CM chondrite bodies. Mission spectroscopic measures of hydration can be used to estimate the extent of dehydroxylation, and the new dehydroxylation thermometer can be used directly to select fragments of returned samples most likely to contain less thermally altered inventories of primitive organic molecules.Often, a community becomes alarmed when high rates of cancer are noticed, and residents suspect that the cancer cases could be caused by a known source of hazard. In response, the US Centers for Disease Control and Prevention recommend that departments of health perform a standardized incidence ratio (SIR) analysis to determine whether the observed cancer incidence is higher than expected. This approach has several limitations that are well documented in the existing literature. In this paper we propose a novel causal inference framework for cancer cluster investigations, rooted in the potential outcomes framework. Assuming that a source of hazard representing a potential cause of increased cancer rates in the community is identified a priori, we focus our approach on a causal inference estimand which we call the causal SIR (cSIR). The cSIR is a ratio defined as the expected cancer incidence in the exposed population divided by the expected cancer incidence for the same population under the (counterfactual) sdence in Endicott, New York.Dose dumping is the major drawback of sustained release (SR) matrices. The current research aimed to develop the stable lipid-based SR matrices of quetiapine fumarate (QTF) using Geleol™ (glyceryl monostearate; GMS) as the lipid matrix carrier and Klucel™ EF (HPC EF), Kollidon® VA64, and Kollidon® 12PF as hydrophilic binders. Formulations were developed using advanced twin screw melt granulation (TSMG) approach and the direct compression (DC) technique. Compared with the blends of DC, the granules of TSMG exhibited improved flow properties and tabletability. Solid-state characterization by differential scanning calorimetry of the prepared granules exhibited the crystalline nature of the lipid. Fourier transform infrared spectroscopy demonstrated no interaction between the formulation ingredients. The compressed matrices of TSMG and DC resulted in the sustained release of a drug over 16-24 h. Upon storage under accelerated conditions for 6 months, the matrices of TSMG retained their sustained release characteristics with no dose dumping in alcohol, whereas the matrices of DC resulted in the dose dumping of the drug attributing to the loss of matrix integrity and phase separation of lipid. Thus, it is concluded that the uniform distribution of a softened binder into a molten lipid carrier results in the stable matrices of TSMG.[This corrects the article PMC8020908.].This study investigates the two-mode core-periphery structures of venue affiliation networks of younger Black men who have sex with men (YBMSM). We examined the association between these structures and HIV phylogenetic clusters, defined as members who share highly similar HIV strains that are regarded as a proxy for sexual affiliation networks. Using data from 114 YBMSM who are living with HIV in two large U.S. Linsitinib mouse cities, we found that HIV phylogenetic clustering patterns were associated with social clustering patterns whose members share affiliation with core venues that overlap with those of YBMSM. Distinct HIV transmission patterns were found in each city, a finding that can help to inform tailored venue-based and network intervention strategies.Prior research has examined associations between state adoption policies and assisted reproductive technology insurance coverage and foster care adoption rates, but knowledge of the relationships between state policies and contexts and foster care adoption is still limited. In this study, we test adoption subsidy policy, alternative means of family formation, and the demographic characteristics of potential adoptive parents and children as predictors of foster care adoption rates at the state-year level using data from the Adoption and Foster Care Analysis and Reporting System and other sources for 2005 to 2016. We use between-within models to obtain random effects estimates between states and fixed effects estimates within states. We find that states with higher average adoption subsidies have lower foster care adoption rates. Foster parent rates, international adoption rates, and mandated in vitro fertilization insurance coverage are positively associated with foster care adoption. States with higher median household incomes and more same-sex couples have higher foster care adoption rates, but states with more women of childbearing age have lower rates of older child adoption.
