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prioritized, especially in individuals at risk for developing de novo BP.Venous thromboembolism (VTE) is common in cancer patients. While in the general population blood type non-O is associated with increased VTE risk, the impact of ABO blood type on risk of cancer-associated VTE has not been clarified. To determine the influence of ABO blood type on cancer-associated VTE risk, we conducted an analysis within the Vienna Cancer and Thrombosis Study (CATS), a prospective cohort study including patients with newly diagnosed or recurrent cancer observed for the primary outcome VTE. Restricted cubic spline analysis was performed and specific time-restricted subdistribution hazard ratios (SHR) were calculated to investigate the association between non-O blood type and VTE over time. 1,708 patients were included in the analysis (median follow-up time 24 months; interquartile range 10-24), and 151 patients developed VTE (8.8%). During the first 3 months of follow-up, there was no association between non-O blood type and VTE risk (SHR 1.00, 95% CI 0.60-1.67). Thereafter, non-O blood type was associated with a higher VTE risk (SHR 1.79, 95%CI 1.12-2.85). Furthermore, non-O blood type was associated with increased VTE risk in patients with intermediate and low thrombotic risk tumor types (SHR 1.73, 95% CI 1.09-2.73), but not in very high-risk types (pancreatic, gastroesophageal and brain cancer; SHR 0.94, 95% CI 0.55-1.61). This association was weakened after adjustment for factor VIII. 1-Naphthyl PP1 concentration Non-O blood type is a time-dependent predictor of VTE in cancer patients. It is associated with increased VTE risk beyond 3 months of follow-up and in patients with intermediate and low-risk tumor types.

Long-term use of oral anticoagulants (OACs) is necessary for stroke prevention in patients with atrial fibrillation (AF). The effectiveness and safety of OACs in extremely older patients (ie, aged 80 years or older) with AF and at high risk of bleeding needs to be elucidated.

To examine the effects of very low-dose edoxaban (15 mg) vs placebo across 3 age strata (80-84 years, 85-89 years, and ≥90 years) among patients with AF who were a part of the Edoxaban Low-Dose for Elder Care Atrial Fibrillation Patients (ELDERCARE-AF) trial.

This prespecified subanalysis of a phase 3, randomized, double-blind, placebo-controlled trial was conducted from August 5, 2016, to December 27, 2019. Patients with AF aged 80 years or older who were not considered candidates for standard-dose OACs were included in the study; reasons these patients could not take standard-dose OACs included low creatinine clearance (<30 mL per minute), low body weight (≤45 kg), history of bleeding from critical organs, continuous use of no significant incidence of bleeding.

ClinicalTrials.gov Identifier NCT02801669.

ClinicalTrials.gov Identifier NCT02801669.

Cumulative exposure to high blood pressure (BP) is an adverse prognostic marker. Assessments of BP control over time, such as time at target, have been developed but assessments of the effects of BP-lowering interventions on such measures are lacking.

To evaluate whether low-dose triple combination antihypertensive therapy was associated with greater rates of time at target compared with usual care.

The Triple Pill vs Usual Care Management for Patients With Mild-to-Moderate Hypertension (TRIUMPH) trial was a open-label randomized clinical trial of low-dose triple BP therapy vs usual care conducted in urban hospital clinics in Sri Lanka from February 2016 to May 2017. Adults with hypertension (systolic BP >140 mm Hg and/or diastolic BP >90 mm Hg or in patients with diabetes or chronic kidney disease, systolic BP >130 mm Hg and/or diastolic BP >80 mm Hg) requiring initiation (untreated patients) or escalation (patients receiving monotherapy) of antihypertensive therapy were included. Patients mbination pill was associated with substantially higher time at target compared with usual care.

To our knowledge, this analysis provides the first estimate of time at target as an outcome assessing longitudinal BP control in a randomized clinical trial. Among patients with mild to moderate hypertension, treatment with a low-dose triple combination pill was associated with substantially higher time at target compared with usual care.

About 1% of children and adolescents worldwide are affected by plaque psoriasis.

To evaluate the long-term efficacy and safety of ixekizumab for pediatric patients with moderate to severe psoriasis.

This multicenter randomized clinical trial (IXORA-PEDS) evaluated pediatric patients with plaque psoriasis. Participants were aged 6 years to younger than 18 years; had moderate to severe psoriasis, which was defined as Psoriasis Area and Severity Index (PASI) of 12 or higher, static Physician's Global Assessment (sPGA) score of 3 or higher, and psoriasis-affected body surface area of 10% or greater at screening and baseline; were candidates for phototherapy or systemic therapy; or had psoriasis that was not adequately controlled by topical therapies. Data analysis, which followed the intention-to-treat principle, was conducted from May to October 2021.

Pediatric patients were randomized 21 to receive either a weight-based dose of ixekizumab every 4 weeks or placebo. After a 12-week placebo-controlled perise response rates were sustained through week 108 of the trial. Safety of ixekizumab was consistent with previously reported findings in this population and the known safety profile of this treatment.

ClinicalTrials.gov Identifier NCT03073200.

ClinicalTrials.gov Identifier NCT03073200.

To measure retina/choroid complex perfusion with magnetic resonance imaging in eyes with acute primary angle-closure (APAC).

Three sequences of magnetic resonance imaging, two anatomical and one perfusional using gadolinium, were acquired in patients who were diagnosed with acute primary angle-closure. Regions of interest were drawn on the perfusional sequence and overlaid to the anatomical sequence. The relative blood volume measured during the first 2 s was considered as the baseline value and the change during the subsequent 28 s was analyzed.

Five eyes of 5 patients with acute primary angle-closure were included (3 with unilateral and 2 with bilateral acute primary angle-closure). Three contralateral eyes and 2 eyes of 2 healthy patients, paired for age and sex, were included in the control group. Acute primary angle-closure patients included 4 (80%) women, with an average age of 65.8 ± 12.37 y, mean intraocular pressure of 56.2 ± 14.67 mmHg, mean arterial pressure of 113.4 ± 8.17 mmHg, and average ocular perfusion pressure of 57.2 ± 13.46 mmHg. In the control group, the mean intraocular pressure was 15.6 ± 2.61 mmHg (p=0.0625), the mean arterial pressure was 107.4 ± 6.57 mmHg (p=1.00), and the average ocular perfusion pressure was 91.8 ± 6.72 mmHg (p=0.0625). The relative blood volume of the retina/choroid complex was -0.127 ± 0.048 in acute primary angle-closure patients and -0.213 ± 0.116 in the controls (p=0.3125).

The magnetic resonance imaging sequence with gadolinium did not show a change in the retina/choroid complex perfusion in the eyes of patients with acute primary angle-closure.

The magnetic resonance imaging sequence with gadolinium did not show a change in the retina/choroid complex perfusion in the eyes of patients with acute primary angle-closure.The purpose of this article was to report a case of intraconal lacrimal gland tissue and to review the literature on lacrimal gland choristoma. The magnetic resonance imaging findings of a biopsy-proven orbital case are also presented. A PubMed database search was performed using the key terms heterotopic, ectopic, aberrant, choristoma, and lacrimal gland to identify all the previously documented studies on lacrimal gland choristoma, in English, Spanish, and French. We classified the lacrimal gland choristoma cases classified according to the location of the lesions, clinical appearance, management, and outcome. The search targeting the period between 1887 and 2019 returned 79 articles, which were reviewed. We found a total of 113 cases of choristomas with normal lacrimal gland tissue. Only two of them were not associated with the eye or its adnexa while the remaining 111 lesions were found either on the ocular surface (n=46) or in the orbit (n=34). Intraocular choristomas were found in 18 patients, and the rest of the lesions were noted either on the eyelids (n=10) or in the lacrimal drainage system (n=3). Orbital and intraocular choristomas are the most harmful lesions as orbital choristomas are frequently associated with permanent diplopia while intraocular lacrimal gland choristomas have a poor visual prognosis and are a common cause of enucleation of the eye. In one of the reported cases, a corneal lacrimal gland choristoma had been experimentally induced by activating the FGF10 signaling pathway. Lacrimal gland choristomas are not uncommon. This peculiar type of lesion has been experimentally induced and may appear in a variety of locations associated with the globe and its adnexa.[This corrects the article doi 10.1590/0102-311X00107521].The study aimed to analyze the trend in the maternal mortality ratio (MMR) according to the ICD classification for maternal mortality (ICD-MM) classification in the state of Rio de Janeiro, Brazil, from 2006 to 2018. This was a time trend study of MMR in Rio de Janeiro according to type of death (direct or indirect) and groups of causes in the World Health Organization (WHO) ICD-MM. MMR was calculated with data from Brazilian Mortality Information System (SIM) and Brazilian Information System on Live Births (SINASC). Trends were estimated with the Joinpoint Regression Program. Of the 2,192 maternal deaths in the state, 61% were from direct causes, 34% from indirect causes, and 5% unspecified. There was a downward trend in total MMR and MMR from direct causes -1.2% (95%CI -2.3; -0.1) per year and -3.8% (95%CI -4.9; -2.6) from 2006 to 2015, respectively. For direct causes, according to the ICD-MM, group 2 (hypertensive causes) predominated, but there was a decrease in eclampsia. Next came group 5 (other complications, featuring category O90 and subcategory O90.3 - peripartum cardiomyopathy) and group 1 (pregnancy with abortive outcomes). Indirect causes showed stability, and the majority belonged to category O99 and its subcategories related to cardiovascular and respiratory diseases. MMR in Rio de Janeiro showed a downward trend from 2006 to 2018, although far short of WHO recommendations and with different patterns among the causes. ICD-MM was useful for identifying major groups of causes, but it is necessary to disaggregate by subcategories to adequately elucidate the etiology of maternal death.This study aimed to estimate social and racial inequalities in self-rated oral health in adults from the Brazilian birth cohort study. This study belongs to 1982 Pelotas (Brazil) birth cohort study. Data from this study was collected for oral health conditions 31 years old (Oral Health Study). The outcome was self-rated oral health, dichotomized into positive (good/very good) and negative (regular/bad/very bad). Analyses were stratified by gender, racial/skin color groups, schooling level and income. For statistical analysis, the slope index of inequality (SII) and the concentration index (CIX) were used. The prevalence of negative self-rated oral health was 36.1%. Social inequalities were observed in self-rated oral health in both absolute and relative terms. A SII of -30.0 (95%CI -43.6; -16.4) was observed for income, and -27.7 (95%CI -41.9; -13.4) for schooling level. Both the individuals' income and the schooling level had negative CIX (CIXincome -14.6 [95%CI -21.2; -8.0] and CIXschooling level -14.1 [95%CI -20.