Papenorris7134

We observed an association between mdSI indices and OPSCC risk and 5-year overall survival. It is possible to use mdLMR as an independent prognostic factor for OPSCC.Slope aspect is an important topographic feature that can influence local environmental conditions. While strong effects of slope aspect on aboveground and belowground communities have been frequently elucidated, how slope aspect affects soil nitrogen (N) cycling microbes remains unclear. Here, we characterized the communities of soil N-cycling microbes on south- and north-facing slopes in an alpine ecosystem, by quantifying (qPCR) and high-throughput sequencing six genes involved in N-fixation (nifH), nitrification (archaeal and bacterial amoA) and denitrification (nirK, nirS and nosZ). We found that the abundance, diversity and community composition of major N-cycling microbes differed dramatically between the two slope aspects, and these variances could be well explained by the aspect-driven differences in environmental conditions, especially soil temperature and moisture. The response patterns of different N-cycling groups to slope aspect were much inconsistent, especially for those with similar functions (i.e. ammonia-oxidizing archaea vs. bacteria, nirK- vs. nirS-reducers), indicating strong niche differentiation between these counterparts. We also observed strong preferences and distinct co-occurrence patterns of N-cycling microbial taxa for the two slope aspects. These findings highlight the importance of slope aspect in determining the abundance, species distribution and community structure of N-cycling microbes, and consequently influencing N-cycling processes and ecosystem functioning.This study examines the language environments of bilingually raised Latinx infants (n = 37) in mother-father families of diverse socioeconomic backgrounds, with a focus on paternal parentese, a speaking style distinguished by higher pitch, slower tempo, and exaggerated intonation. Two daylong audio recordings were collected on weekends, when both parents were at home. Paternal, maternal, and infant speech variables were quantified through automatic and manual analyses. Most infants experienced Spanish and English within child-directed speech, and language mixing was common in mothers and fathers. Adjusting for demographic variables, infants heard 50.4% less talk from men compared to women, and 43.4% less parentese from fathers compared to mothers. However, when controlling for overall speech amount, the rate of parentese use did not differ between mothers and fathers, demonstrating that, contrary to the stereotype, fathers in Latinx families adjust their speech in verbal interactions with their infants. An asymmetry emerged, where paternal parentese was associated with paternal knowledge of language development but not with paternal involvement in childcare responsibilities; the opposite was true for paternal speech amount. Controlling for maternal contributions, paternal parentese was predictive of concurrent parent-infant turn-taking and infant language vocalizations, demonstrating its important role in infant language development.One of the important steps for realizing artificial intelligence is identifying elementary units that are beneficial for neural network construction. A type of memristive behavior in which phase-change nanoclusters nucleate adaptively in two adjacent dielectric layers with distinct distribution patterns is demonstrated. This memristive system responds in potentiation to increased stimulation strength and fire action potential after threshold stimulation. Reversible nucleation of phase-change nanoclusters is confirmed after both in situ and ex situ examinations using high-resolution transmission electron microscopy. The dynamics at the nanoscale level dominates the actions of the two dielectric layers. The oscillation response over a long period is due to the competition between crystalline and amorphous phases in the layer near the bottom electrode. Weight mutation, that is, action potential firing, is caused by the blockage of the filament in the layer near the top electrode. The memristive system is compact and able to execute complicated functions of a complete neuron and performs an important role in neuromorphic computing.Climate changes and anthropogenic nutrient enrichment widely threaten plant diversity and ecosystem functions. Understanding the mechanisms governing plant species turnover across nutrient gradients is crucial to developing successful management and restoration strategies. We tested whether and how soil microbes, particularly arbuscular mycorrhizal fungi (AMF), could mediate plant community response to a 15 years long-term N (0, 4, 8, and 16 g N m-2 year-1 ) and P (0 and 8 g N m-2 year-1 ) enrichment in a grassland system. We found N and P enrichment resulted in plant community diversity decrease and composition change, in which perennial C4 graminoids were dramatically reduced while annuals and perennial forbs increased. Metabarcoding analysis of soil fungal community showed that N and P changed fungal diversity and composition, of which only a cluster of AMF identified by the co-occurrence networks analysis was highly sensitive to P treatments and was negatively correlated with shifts in percentage cover of perennial C4 graminoids. Moreover, by estimating the mycorrhizal responsiveness (MR) of 41 plant species in the field experiment from 264 independent tests, we found that the community weighted mean MR of the plant community was substantially reduced with nutrient enrichment and was positively correlated with C4 graminoids percentage cover. Both analyses of covariance and structural equation modeling indicated that the shift in MR rather than AMF composition change was the primary predictor of the decline in perennial C4 graminoids, suggesting that the energy cost invested by C4 plants on those sensitive AMF might drive the inferior competitive abilities compared with other groups. Our results suggest that shifts in the competitive ability of mycorrhizal responsive plants can drive plant community change to anthropogenic eutrophication, suggesting a functional benefit of mycorrhizal mutualism in ecological restoration following climatic or anthropogenic degradation of soil communities.Dialectical Behaviour Therapy (DBT) programmes are often the only available treatment for people diagnosed with borderline personality disorder and were rapidly converted to online delivery during the COVID-19 pandemic. Limited research exists surrounding how the major elements of DBT are delivered in an online environment. This scoping review considered the operationalization of online delivery of DBT and its effectiveness. EBSCO host databases were searched using free text. Of 127 papers, 11 studies from 2010 to 2021 investigating online DBT for any clinical population were included in the review. A narrative synthesis of papers selected was undertaken. Seven articles reported results from five clinical trials (n = 437). Most adaptations mirrored face-to-face programmes although there was considerable variation in how therapy was facilitated. Attendance was reported to be greater online with comparable clinical improvements to face-to-face for those who remained in therapy. Additional challenges included managing risk, therapist preparedness and technology difficulties. Online delivery of DBT programmes is feasible and may be more accessible, acceptable and as safe and effective as face-to-face delivery. However, mirroring face to face delivery in an online environment may not be the most effective and efficient way to adapt DBT to online provision. Research is needed to identify areas which require further adaptation.

The COVID-19 pandemic has influenced all social spaces and older adults are susceptible to COVID-19. Geriatric caregivers in nursing homes might experience death anxiety when faced with infected older adults and a closed working environment. Death anxiety is a negative and formidable affective state. Yet, little is currently known about the relationships among death anxiety, self-esteem, and health-related quality of life among geriatric caregivers during the COVID-19 pandemic. This study aimed to examine whether self-esteem could moderate the association between death anxiety and health-related quality of life during the pandemic.

A cross-sectional study was conducted in Jinan and Heze cities, Shandong Province, from November 2020 to January 2021. Participants comprised a convenience sample of 236 geriatric caregivers in nursing homes. Data on sociodemographic variables, death anxiety, self-esteem, and health-related quality of life were collected. A-966492 Descriptive analysis, Pearson correlation, and moderated analysis were used for statistical analysis.

Self-esteem moderated the association between death anxiety and health-related quality of life (death anxiety × self-esteem B=-0.113, 95% CI -0.143, -0.018).

This study revealed that self-esteem played a moderating role between death anxiety and health-related quality of life during the pandemic, which implies that mental health should be given more attention, and that interventions for improving self-esteem need to be carried out.

This study revealed that self-esteem played a moderating role between death anxiety and health-related quality of life during the pandemic, which implies that mental health should be given more attention, and that interventions for improving self-esteem need to be carried out.

Neurofibromatosis type I (NF1) is a rare genetic disorder, associated with some physical symptoms including spots and tiny bumps on the skin, and internal organ involvement. People suffering from neurofibromatosis face various challenges in their daily lives. However, there is little understanding on how patients deal with neurofibromatosis. This study aimed to investigate the life challenges of patients with NF1.

This qualitative study was performed by implementing a grounded theory with the cooperation of the Society for Neurofibromatosis Patients over the course of 15 months in 2019 across 4 provinces in Iran. Twenty-four patients with NF1 were interviewed. An analysis was performed using the constant comparative method.

The results of the analyses indicated that the major concern of the NF1 patients was feelings of failure and falling behind in life. In the face of failure in life in such a context, patients used the main strategy of "unsuccessful struggle to escape" the disease and its complications, which was represented itself in the forms of 'hopelessness and impatience', 'suicidal thoughts and unsuccessful suicide attempts', 'isolation and seclusion', 'expressing complaints and grievances to God', 'hiding the disease' and 'hopelessness and refusing to receive care'. The implementation of such strategies helped patients reduce tension and achieve a temporary, though vulnerable and fragile, sense of relief and peace.

Given an unfavourable life condition, NF1 patients turned to a harmful passive strategy in the face of the challenges posed by the disease.

Public contributors were active partners throughout, and co-authored the paper.

Public contributors were active partners throughout, and co-authored the paper.