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Cd 48.33 ± 3.07 vs. 37.5 ± 2.14, P less then 0.05) and plasma D-lactate (ctrl vs. Cd 1.88 ± 0.20 vs. 2.80 ± 0.15, P less then 0.01) and diamine oxidase (ctrl vs. Cd 5.00 ± 0.87 vs. 11.21 ± 2.17, P less then 0.05) were increased in cadmium-treated mice, indicating an elevated intestinal permeability. In vitro results showed that long-term exposure of cadmium down-regulated the expression and membrane localization of adherent and tight junction proteins in a time-dependent manner. In conclusion, long-term exposure of environmental dose of cadmium aggravated DSS-induced chronic colitis and disrupted intestinal barrier and impaired the adherent and tight junction proteins. These findings provide a better understanding about the health risk of cadmium in the environment.Humans possess limited knowledge on what generated cultural dynamics to strengthen human resilience to overcome climate-induced stresses. Although the highly developed mental ability of humans could have enabled significant human resilience in history, no study has empirically explained or has even scientifically confirmed how and when such dynamics arose. To fill the current research gap, this study therefore explores the associations among climatic conditions, the evolutional dynamics of human thinkers and their thoughts, and human ecological-socioeconomic conditions in the past 2500 years in Europe. Results from quantitative modellings and causal analyses confirm that climatic-ecological stresses led to human ecological-socioeconomic crises, and thereby dramatically increased twice of the thinkers' number and their thoughts' impact across different philosophies in truth, knowledge, and ethics for adaptation at multi-decadal to centennial temporal scales, especially in spirituality oriented mentality. The process of the stress-generated cultural dynamics displays some similarities with the stress-induced mutagenesis in organism evolution. Ultimately, climatic-ecological stresses prompt the escalation in the number of thinkers and impacts of their thoughts and flourishing of philosophy. Such stress-regenerated cultural dynamics imply that the current climate change threat may stimulate another thriving phase of cultural selection and lift humans to the next homeostatic plateau of civilization. CHR2797 order Findings also extend the cognate scope of psychological, sociological, and civilization studies.China transitioned into "new normal phase" during 2007 to 2017, shifting from pursuing rapid GDP growth to a win-win state of economic development and environmental improvement. Using the input-output (IO) table for 2007-2012 and the latest IO table for 2012-2017, an IO model of China's industrial SO2 emissions is established and structural decomposition analysis (SDA) is applied to examine the changes in industrial SO2 emissions resulting from this economic transition. Five influencing factors (emission intensity, production technology, final demand expenditure, final demand structure and economic scale) are taken into consideration. The analysis shows that emission intensity and economic scale are the most influential factors on SO2 emissions. Emission intensity reduced SO2 emissions by 16,560,886 t in 2012-2017 whilst economic scale increased SO2 emissions by 473,490 t. Compared with the period 2007-2012, the contribution rate of emission intensity increased from -82.3% to -189.2%, while that of economic scale decreased from 131.8% to 54.1%. The total contributions of 5 factors to SO2 reduction increased from -5,249,417 t to -12,783,248 t, and the contribution rate increased from -24.8% to -146%. China's energy conservation and emission reduction has achieved remarkable results between 2007 and 2017. In "new normal phase", the slowing of China economic growth, the transition of economic development, industrial structural adjustment and rational consumption habits have had significant effects in reducing environmental pollution.World food production is directly related to human population growth. Chemicals are constantly applied to pest control in crops to increase productivity. Therefore, sustainable alternatives are needed to reduce environmental impacts. The biochemical responses in liver and muscle of Astyanax lacustris collected in different rice planting systems were analysed. Ten fish were collected in organic rice cultivation systems and conventional as well as water and sediment for pesticide analysis. In water from conventional system, bentazon (56.1 μg L-1), fipronil (0.226 μg L-1) and propoxur (0.141 μg L-1) were found, while azoxystrobin and quinclorac were below the limit of quantification (LOQ). There were no pesticides in the sediment from the conventional system. In the water of the organic system, only propoxur (below the LOQ) was registered. Metalaxil (0.025 μg kg-1) were verified in the sediment, while diphenoconazole, dinoxifene and tebuconazole were below the LOQ. The presence of these pesticides in crops with an organic production system may be related to proximity to crops to conventional production systems. Besides this, the amount is very low as compared with conventional system. Muscle glycogen, protein and amino acid levels were higher in fish collected in organic ponds. Lactate and ammonia levels were higher in conventional cultures. Lipids and proteins had greater oxidative damage in both tissues in the conventional system. Although pesticides were detected in organic sediments, the parameters of metabolic and oxidative damage were probably related by exposure to higher concentrations of pesticide in the water or by the lower oxygen content of conventional systems. However, fish mortality was not observed during collections. Despite being an anthropic environment, areas of organic cultivation seem to present better conditions for the survival of A. lacustris.Water hyacinth is considered to be among the worst invasive weed species globally, causing detrimental environmental and social problems worldwide. It rapidly grows, and therefore has significant potential as a resource. Due to its high moisture content (approximately 95%), the by-product obtained by dehydrating water hyacinth yields a considerable amount of water hyacinth juice (WHJ). In this study, we performed a comparative assessment of long-term energy efficiency, maximum treatment capacity limits, and microbial community dynamics of modified internal circulation (MIC) and up-flow anaerobic sludge blanket (UASB) reactors in response to increasing loadings of WHJ. The MIC reactor exhibited a higher energy recovery rate and stronger performance compared with the UASB reactor. The optimal organic loading rates of the MIC and UASB reactors were 17.93 and 8.85 kg chemical oxygen demand (COD)/m3/d, with methane conversion rates of 0.21 and 0.15 m3 CH4/kg COD, respectively. Furthermore, the engineering costs and project floor space required by the MIC reactor are less than those in the case of the UASB reactor.