Padgetthorner0112

With real-time IGRT, no treatments had prostate CTV D98% dose 5% less than planned. Without real-time IGRT, 13 treatments (5·5%) had prostate CTV D98% doses 5% less than planned. The prostate CTV D98% dose with real-time IGRT was closer to the plan by an average of 1·0% (range -2·8% to 20·3%). Patient outcomes show no change in the 12-month patient reported outcomes compared with baseline and no grade ≥3 GU or GI toxicities. CONCLUSION Real-time IGRT is clinically effective for prostate cancer SABR. BACKGROUND Radiation therapy interruption (RTI) worsens cancer outcomes. Our purpose was to benchmark and map RTI across a **** region in the United States with known cancer outcome disparities. METHODS All RT treatments at our academic center were cataloged. Major RTI was defined as >5 unscheduled RT appointment cancellations. Univariate and multivariable (MVA) logistic and linear regression analyses identified associated factors. Major RTI was mapped by patient residence. A two-sided p-value of 2 RT interruptions. 337 patients (9%) had major RTI. Disparities in major RTI were seen across Medicaid vs. commercial/Medicare insurance (22.5% vs. 7.2%, p= less then 0.0001), low vs. high predicted income (13.0% vs. 5.9%, p= less then 0.0001), Black vs. White race (12.0% vs. 6.6%, p= less then 0.0001), and urban vs. suburban treatment location (12.0 vs. 6.3%, p= less then 0.0001). On MVA, increased odds of major RTI were seen for Medicaid patients (OR 3.35 95%CI 2.25-5.00, p= less then 0.0001; v commercial/Medicare), and head & neck (OR 3.74 95% CI 2.56-5.46, p= less then 0.0001), gynecologic (OR 3.28 95%CI 2.09-5.15, p= less then 0.0001), and lung cancers (OR 3.12 95%CI 1.96-4.97, p= less then 0.0001) compared to breast cancer. Major RTI mapped to urban, majority Black, low-income neighborhoods, as well as to rural, majority White, low-income regions. CONCLUSION Radiation treatment interruption disproportionately impacted financially and socially vulnerable patient populations and mapped to high poverty neighborhoods. Geospatial mapping affords an opportunity to correlate RT access on a neighborhood level to inform potential intervention strategies. Speeding behaviour is known to influence crash risk among alcohol-impaired drivers, but this relationship is scarcely explored. The present study investigated the effects of different Blood Alcohol Concentrations (BAC) levels on driving performance with respect to mean speed of drivers and their ability to avoid crashes during sudden events while driving. Eighty-two drivers participated in the simulation driving experiment at four BAC levels (0%, 0.03 %, 0.05 % and 0.08 % BAC) in rural and urban driving scenarios. Two sudden events (pedestrian crossing and road crossing by parked vehicles (a car and a truck) in the perpendicular direction of traffic) were designed to evaluate the crash probabilities in both the driving scenarios. Generalized linear mixed models were developed to analyse the effects of BAC levels and driver attributes (e.g., age, gender) on mean speeds and crash probabilities. Results for mean speed showed that, compared to sober state, drivers drove 3.5 kmph, 5.76 kmph and 8.78 kmph faster at 0.03 %, 0.05 % and 0.08 % BAC respectively in the rural environment and this increment was 3.6 kmph, 3.69 kmph and 4.13 kmph in the urban environment. The model results for crash probabilities revealed that 0.03 %, 0.05 % and 0.08 % BAC levels increased the crash probabilities by 1.9 times, 2 times and 3 times in case of the rural environment and 2 times, 2.3 times and 3.5 times respectively in the urban driving environment. As a widespread and reversible post-translational modification of proteins, S-glutathionylation specifically generates the mixed disulfides between cysteine residues and glutathione, which regulates various biological processes including oxidative stress, nitrosative stress and signal transduction. The identification of proteins and specific sites that undergo S-glutathionylation is crucial for understanding the underlying mechanisms and regulatory effects of S-glutathionylation. Experimental identification of S-glutathionylation sites is laborious and time-consuming, whereas computational predictions are more attractive due to their high speed and convenience. Here, we developed a novel computational framework DeepGSH (http//deepgsh.cancerbio.info/) for species-specific S-glutathionylation sites prediction, based on deep learning and particle swarm optimization algorithms. 5-fold cross validation indicated that DeepGSH was able to achieve an AUC of 0.8393 and 0.8458 for Homo sapiens and Mus musculus. According to critical evaluation and comparison, DeepGSH showed excellent robustness and better performance than existing tools in both species, demonstrating DeepGSH was suitable for S-glutathionylation prediction. The prediction results of DeepGSH might provide guidance for experimental validation of S-glutathionylation sites and helpful information to understand the intrinsic mechanisms. "Blast hand" is a traumatic hand injury related to an explosion. Artisanal gold miners use dynamite to excavate gold pits; such activities expose them to blast hand injuries. This work aims to study blast injuries to gold miners' hands. A 25-month retrospective study was performed. Data on the traumatic event, patients, and injuries were collected and analyzed. Dedicated classifications and scores were used to evaluate the injury topography, injury severity, physical dependence, and aesthetic impact. Data were analyzed statistically. Thirty patients with 46 blast hand injuries among 516 hand injuries were collected. N-Methyl-D-aspartic acid concentration All patients were males and full-time artisanal gold miners. They were seen in the emergency room an average of 10.2hours (1-72) after the explosion. Explosions were caused by a 500g dynamite charge in all cases. The detonation was mainly thermal (n=13), triggered by the patient himself (n=24) and inside the gold pit (n=20). Injuries were bilateral (53%) or left side predominant (59%). Complex injuries were present in 21 hands. The MHISS (Modified Hand Injury Severity Score) was severe (n=7) and major (n=32). Associated injuries were musculoskeletal (n=12), ophthalmologic (n=14) and maxillofacial (n=10). Complexes injuries were correlated to being inside the pit at the time of the explosion. Treatment was conservative more often (n=33) than amputation (n=13). The functional recovery was complete in 22 hands (10 patients). Return to work at the same level was possible for only eight hands (5 patients). The presence of local sequelae or associated injuries negatively impacted the return to work. In Burkina Faso, gold miner's blast hand injuries cause post-traumatic social and professional reintegration issues. Better regulation of artisanal gold mining and expansion of treatment modalities (microsurgery, hand rehabilitation, splinting) may improve the outcome.