Ottosloth2326

Multiple regression analyses showed that poor mental health (adjusted odds ratio 2.17 [95%CI 1.45-3.25]) promoted new onset of Internet addiction and Internet addiction (adjusted odds ratio 2.39 [95%CI 1.36-4.20]) also promoted new onset of poor mental health.

Internet addiction and poor mental health status each increased the risk of onset of the other. Adolescents, their parents and schools need to take policies to use properly Internet.

Internet addiction and poor mental health status each increased the risk of onset of the other. Adolescents, their parents and schools need to take policies to use properly Internet.

The Coronavirus disease 2019 (COVID-19) pandemic outbreak has led to travel bans and restricted social contact. Sudden decrease of social activities can easily trigger social anxiety, especially for community youths. Existing studies have inconclusive results regarding whether the development of youths' social anxiety can be predicted by psychological capital. This study aims to clarify the influence mechanisms of psychological capital and coping style on social anxiety during the COVID-19 pandemic outbreak.

Overall 600 community youths with ages of 18-22 yr in Northeast China were randomly selected and voluntarily answered the online questionnaire survey in Mar 2020. General information questionnaire form, positive psychological capital questionnaire, social interaction anxiety scale, and simple coping style questionnaire were used to obtain the participants' information.

Psychological capital has a medium negative correlation with social anxiety, low positive correlation with positive coping (

= -0.42, 0.38), and low negative correlation with negative coping (

= -0.19). Social anxiety is negatively correlated with positive coping to a small degree and positively correlated with negative coping at a medium level (

= -0.16, 0.43). Positive coping has a low positive correlation with negative coping (

= 0.13). Positive coping and negative coping play partial mediating roles between psychological capital and social anxiety, with mediating effect values of -0.03 and 0.01, respectively.

Youth's psychological capital is closely associated with coping style and social anxiety. In addition to its direct bearing on social anxiety, psychological capital influences social anxiety through the mediating effect of coping style.

Youth's psychological capital is closely associated with coping style and social anxiety. In addition to its direct bearing on social anxiety, psychological capital influences social anxiety through the mediating effect of coping style.

Glucose transporter-1 (GLUT-1) has been differentially expressed in various malignancies including gastric cancer (GC). Several previous meta-analyses of GLUT-1 have some significant limitations, such as researching the association between GLUT-1 and various cancer types with no specificity, not studying clinicopathological parameters with GLUT-1, existing conspicuous heterogeneity and so forth. Therefore, we performed a meta-analysis to evaluate the association between GLUT-1 expression and survival of gastric cancer patients, as well as clinicopathological characteristics.

We systematically searched PubMed, Embase, Web of Science and China National Knowledge Infrastructure for relevant studies in accordance with the applicable criteria up to Aug 2017. Hazard ratios (HRs) and odds ratios (ORs) with their 95% confidence intervals (CIs) were used as the effective measures.

A total of 13 studies involving 1972 patients were included in this meta-analysis. The results demonstrated that there was a significant association between GLUT-1 expression and overall survival (OS) (HR=1.45, 95% CI=1.13-1.87) or disease-free survival (DFS) (HR=2.18, 95% CI=1.46-3.25). Moreover, GLUT-1 expression was significantly correlated with worse tumor nodes metastases (TNM) stage (OR=0.34, 95% CI=0.28-0.43), presence of lymph node metastasis (OR=2.88, 95% CI=1.34-6.19), intestinal type of Lauren classification (OR=3.84, 95% CI=2.57-5.74) and invasion of serosa (OR=0.25, 95% CI=0.18-0.35).

Our meta-analysis showed that GLUT-1 was significantly correlated with poor OS and DFS in gastric cancer. Additionally, GLUT-1 was also a potential prognostic indicator of aggressive clinicopathological parameters in gastric cancer.

Our meta-analysis showed that GLUT-1 was significantly correlated with poor OS and DFS in gastric cancer. Additionally, GLUT-1 was also a potential prognostic indicator of aggressive clinicopathological parameters in gastric cancer.The coronavirus disease-19 (COVID-19) negatively affects immune system. It is linked with adverse pregnancy outcomes. These complications may be linked with the infections mediated deficiency of micronutrients in pregnant women. Selleck Avadomide COVID-19 cause's malabsorption of micronutrients thereby increases the risk of their deficiency. Both micronutrients deficiencies and poor micronutrients intake can compromise immune function and may increase the risk of pregnancy complications associated with COVID-19 infection. Vita-min A, C, D, E, and selected minerals iron (Fe), selenium (Se), and zinc (Zn) are the micronutrients essential for immuno-competency and play a significant role in the prevention of adverse pregnancy outcomes. Immune function and pregnancy outcomes can be improved by adequate intake of micronutrients in diet or in supplements form. Based on regulatory links between viral infection, micronutrients, immunity, and pregnancy outcomes, this review highlights the role of micronutrients in boosting immunity to reduce or prevent pregnancy complications in COVID-19 infected women.

COVID-19 is a public health emergency of international concern. Its incidence rates and mortality are very high; however, so far, an effective drug treatment remains unknown. Based on the role of convalescent plasma therapy in previously identified viral pneumonias, patients with severe COVID-19 have been given this therapy. This systematic review and meta-analysis aimed to summarize the clinical evidence regarding the efficacy and safety of convalescent plasma therapy in the treatment of severe COVID-19.

PubMed, Embase, Ovid, China Knowledge Network, China Biomedical, VIP Chinese Sci-tech Journal, Wanfang Database, and the International Clinical Trials Registry Platform were searched up to 21 June 2020, to identify clinical studies and registered trials on the use of convalescent plasma in the treatment of critically ill patients with COVID-19. Stata 13.0 was used to perform Meta-analysis. All records were screened as per the protocol eligibility criteria.

Nineteen clinical reports regarding convalescent plasma in the treatment of severe COVID-19 were included.